Labrafac™ PG

An oily vehicle and solubilizer for lipophilic APIs in topical dosage forms. Widely used as a vehicle in veterinary parenteral formulations.

Names and synonyms

USP NF Name

Propylene glycol dicaprolate/dicaprate

EP Name

Propylene glycol dicaprylocaprate

UNII Code (FDA)

O4446S9CRA

Preferred Substance Name (FDA)

PROPYLENE GLYCOL DICAPRYLATE/DICAPRATE

Handbook of Pharmaceutical Excipients

/

Chemical description

Consists of propylene glycol esters of caprylic (C8) and capric (C10) acids

Key characteristics

Product form

Liquid

Viscosity (mPa.s)

9 – 12 (20°C)

HLB

1

Main functionalities

Oily phase for topical formulations.
Oily vehicle and solubilizer for solutions.
Safety of use is inferred by substantial toxicological data and precedence of use in approved human and veterinary pharmaceutical products.

Main formulation technologies

Topical ointment, emulsion, microemulsion, foam.
Parenteral solution (veterinary).