A non-ionic pure surfactant for lipid-based formulation to solubilize and increase oral bioavailability of poorly soluble API. Forms micellar solution in aqueous media.
Polyethylene glycol monostearate
Macrogol stearate (pending)
Consists of PEG-32 (MW 1500) esters of palmitic (C16) and stearic (C18) acids
153 ± 31
Solubilizer for low log P APIs and bioavailability enhancer.
Single excipient formulation system: self-emulsifies in aqueous fluid into micellar solution—LFCS Type IV.
Use in melt processes (granulation, extrusion), granulation, and compression.
Safety of use is inferred by precedence of use in approved pharmaceutical products.