Gelot™ 64

A nonionic oil-in-water emulsifier for topical emulsions. It provides excellent emulsion stability with difficult-to-formulate and combination APIs. Provides heat stability and high tolerance over a wide pH range.

Names and synonyms

USP NF Name

Mono and Diglycerides and Polyoxyl stearate

EP Name

Glycerol monostearate and macrogol-75 stearate

UNII Code (FDA)

230OU9XXE4
OT38R0N74H

Preferred Substance Name (FDA)

GLYCERYL MONOSTEARATE
PEG-75 STEARATE

Handbook of Pharmaceutical Excipients

Glyceryl monostearate
Polyoxylethylene stearates

Chemical description

Consists of a mixture of glycerol monostearate and PEG-75 (MW 3500) stearate (C18)

Key characteristics

Product form

Pellets

Melting range

55.5 – 62.5

HLB

10

Main functionalities

Emulsifier for difficult-to-formulate APIs, API combinations, anhydrous emulsion.
Associate with Emulcire™ 61 WL2659 to enhance sensorial and texture properties.
Safety of use is inferred by precedence of use in approved pharmaceutical products.

Main formulation technologies

Topical emulsion, emulgel, and foam.
One-pot formulation process can facilitate manufacturing.