Gattefosse case studies for Pharmaceuticals

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How to obtain sustained release tablets of metformin hydrochloride by direct compression ?

The aim was to develop dual SR matrix tablets by direct compression with an equivalent drug release profile to the two doses available as market references (500 and 750 mg).

Keywords: dual matrix, sustained release, metformin hydrochloride, Compritol® 888 ATO, HPMC, direct compression, high drug load

How to reduce drug release variability in HPMC-based sustained-release tablets ?

The aim of this study was to develop a sustained-release tablet formulation using two SR agents, HPMC and Compritol® 888 ATO, in order to reduce the variations in drug release.

Keywords: tablet, sustained release, metformin hydrochloride, dual matrix, wet granulation process, HPMC, Compritol® 888 ATO

 

How to formulate a simple emulgel with a high level of Transcutol® P

In this study, a design of experiment (DoE) was performed to assess the effects of emulsifiers and Transcutol® concentrations on emulgel appearance, pH, viscosity and stability after 24h, 1, 3, 6 and 12 months at 40°C.

Keywords: Emulgel, Transcutol®, Gelot™64, Emulcire® 61 WL 2659, stability, viscosity, pH