An oily vehicle used as solubilizer for lipophilic APIs in oral and topical formulations.
Names & synonyms
|USP NF Name||
Glyceryl monooleate (Type 40)
Glycerol mono-oleates (Type 40)
|UNII Code (FDA)||
|Preferred Substance Name (FDA)||
|Handbook of Pharmaceutical Excipients||
Consists of mono-, di- and triglycerides of oleic (C18:1) acid, the monoester fraction being predominant
Solubilizer for lipophilic APIs and bioavailability enhancer. Oily vehicle containing long-chain fatty acids (C18:1) for LFCS Type I (oily), Type II (SEDDS), and Type III (SMEDDS), associated with lymphatic absorption. Oily vehicle for topical formulations. Safety of use is inferred by GRAS status and precedence of use in approved pharmaceutical products.
Main formulation technologies
Soft and hard gelatin capsule filling. Topical emulgel and ointment.