Publications on oral peptide delivery
Self-emulsifying drug delivery systems (SEDDS): In vivo-proof of concept for oral delivery of insulin glargine
Victor Claus , Helen Spleis, Christoph Federer, Katrin Z ̈oller, Richard Wibel, Flavia Laffleur, Camille Dumont, Philippe Caisse, Andreas Bernkop-Schnürch
International Journal of Pharmaceutics 639 (2023) 122964
In this study, lipophilicity of insulin glargine (IG) was successfully increased via hydrophobic ion pairing (HIP) with sodium octadecyl sulfate to enable incorporation into self-emulsifying drug delivery systems (SEDDS). The SEDDS formulations F1 and F2 were administered to rats via oral gavage and resulted in a bioavailability of 0.55% and 0.44%, corresponding to a 7.7-fold and 6.2-fold increased bioavailability, respectively. Thus, incorporation of complexed insulin glargine into SEDDS formulations provides a promising approach to facilitate its oral absorption.
A proof-of-concept for developing oral lipidized peptide Nanostructured Lipid Carrier formulations
Camille Dumont, Vincent Jannin, Cédric Miolane, Quentin Lelong, Jean-Pierre Valour, Sebastien Urbaniak, Hatem Fessib, Sandrine Bourgeois
Journal of Drug Delivery Science and Technology (article in press)
In this study, the authors developed a protocol to produce reproducible solid lipid nanoparticles by high pressure homogeneization. The possibility to encapsulate peptides was also investigated.
In Vitro Studies Indicate Promising Properties Of Solid Lipid Nanosuspensions for oral peptide delivery
Camille Dumont, Ana Beloqui, Sandrine Bourgeois, Véronique Préat, Hatem Fessi, Vincent Jannin
Poster CRS 2019
In-vitro evaluation of solid lipid nanoparticles: Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract
Camille Dumont, Sandrine Bourgeois, Hatem Fessib, Pierre-Yves Dugas, Vincent Jannin
International Journal of Pharmaceutics, Volume 565, 30 June 2019, Pages 409-418
Lipid-based nanosuspensions for oral delivery of peptides, a critical review
Camille Dumont, Sandrine Bourgeois, Hatem Fessi, Vincent Jannin
- the different techniques used to prepare Solid Lipid Nanoparticles and Nanostructured Lipid Carriers
- the methods used to assess the protective effects of the carriers on peptides
- the techniques used to measure the permeability enhancement
Self-emulsifying peptide drug delivery systems: How to make them highly mucus permeating
Janine Griesser, Gergely Hetényi, Hatice Kadas, Frédéric Demarne, Vincent Jannin and Andreas Bernkop-Schnürch
The aim of this study was to evaluate the mucus permeating properties of self-emulsifying drug delivery systems (SEDDS). Small droplet size and negative zeta potential of SEDDS could be identified as key parameters for their mucus permeating properties.
Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione
Gergely Hetényi, Janine Griesser, Michael Moser, Frédéric Demarne, Vincent Jannin, Andreas Bernkop-Schnürch.
International Journal of Pharmaceutics, Volume 523, Issue 1, 15 May 2017, Pages 357–365 This study shows that independent from the type of peptide all the SEDDS showed a prolonged release and can provide a 100% protective effect towards protease degradation and deactivation by reduced glutathione.
Hydrophobic ion pairing: Key to highly payloaded self-emulsifying peptide drug delivery systems
Janine Griesser, Gergely Hetényi, Michael Moser, Frédéric Demarne, Vincent Jannin, Andreas Bernkop-Schnürch.
International Journal of Pharmaceutics, Volume 520, Issues 1–2, 30 March 2017, Pages 267–274 In this study, hydrophobic ion pairing is used to form complexes between different anionic surfactants and leuprorelin, insulin and desmopression as model peptides. These complexes were formulated in SEDDS and evaluated for payload and stability.
