Publications on granulation

List of Gattefossé publications on granulation.

Impact of hot and wet granulation techniques on Compritol® 888 ATO lipid matrices for extended release of highly water soluble high dose API

Ketkee Deshmukh, Chhanda Kapadia, Agnivesh Shrivastava, Gayatri Khanvilkar, Pradnya Vaingankar and Purnima Amin

CRS 2016

The poster describes the formulation of sustained release tablets with Metformin HCl (a well-known oral antihyperglycemic) using Compritol® 888 ATO as a sustained release agent. Different granulation techniques were evaluated to elucidate the impact of formulation and process on tablet properties and drug release. The objective was to determine a simple process that enables the production of ‘smaller’ tablets, using less excipients, whilst maintaining therapeutic drug dose and obtaining drug release which passes Pharmacopeial specifications.

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Continuous twin screw melt granulation of glyceryl behenate: Development of controlled release tramadol hydrochloride tablets for improved safety.

Keen JM, Foley CJ, Hughey JR, Bennett RC, Jannin V, Rosiaux Y, Marchaud D, McGinity JW.

Int J Pharm. 2015 Jun 20;487(1-2):72-80

The objective of this study was to develop a continuous granulation process for direct production of granules using this technique with glyceryl behenate as a binder, evaluate the properties of the resulting granules and develop controlled release tablets containing tramadol HCl.

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Optimizing a wet granulation process to obtain high-dose sustained-release tablets with Compritol® 888 ATO.

Yvonne Rosiaux, Jean-Michel Girard, Florence Desvignes, Cédric Miolane and Delphine Marchaud. Drug Dev Ind Pharm. 2015 Feb 5.

This study demonstrates how a wet granulation with Compritol® 888 is an effective approach to improve material flow and compressibility. High-dose lipid matrix tablets with sustained release profiles were successfully produced.

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High Drug Load Lipid Matrix Tablets Prepared by Wet Granulation: PART I – Formulation Parameters

Yvonne Cuppok-Rosiaux, Jean-Michel Girard, Florence Desvignes, Cédric Miolane and Delphine Marchaud.

AAPS 2013

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High Drug Load Lipid Matrix Tablets Prepared by Wet Granulation:
PART II – Process Parameters

Yvonne Cuppok-Rosiaux, Jean-Michel Girard, Florence Desvignes, Cédric Miolane and Delphine Marchaud.

AAPS 2013

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