Continuous twin screw melt granulation of glyceryl behenate: Development of controlled release tramadol hydrochloride tablets for improved safety.
Keen JM, Foley CJ, Hughey JR, Bennett RC, Jannin V, Rosiaux Y, Marchaud D, McGinity JW.
Int J Pharm. 2015 Jun 20;487(1-2):72-80
The objective of this study was to develop a continuous granulation process for direct production of granules using this technique with glyceryl behenate as a binder, evaluate the properties of the resulting granules and develop controlled release tablets containing tramadol HCl.
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