Selecting efficient pharmaceutical binder for developing robust extended release matrices of Compritol ® 888ATO prepared using wet granulation technique
Part 1 Studying impact on granule & tablet properties
Part 2 Studying impact on dissolution profiles of ER tablets of different API’s
K. Deshmukh, A. Shrivastava, S. Banerjee, R. Tiwari, S. Bambarkar, N. Farah
This study evaluates the binding efficiency of four commonly used pharmaceutical binders to hold hydrophilic API’s of different solubilities with hydrophobic, waxy ER matrices of Compritol ® 888 ATO as sustained release agent by studying their impact on the granule and tablet properties formulated using the same.
Poor solubility, poor permeability, and pre-systemic elimination are factors that can limit absorption of somedrugs. Lipid excipients have the capability to overcome these hurdles and enhance oral bioavailability throughdifferent mechanisms.
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How to develop lipid-based formulation?
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An optimized LBF enables solubilization of the entire therapeutic dose andmaintains the drug in solubilized state throughout the digestion process.
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To speed up LBF development, we have produced tools to guide you at each stageof development:
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1 – methods for saturation solubility screening
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2 – database of solubility of drugs in common pharmaceutical excipients
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3 – methods for miscibility and dispersability testing
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4 – miscibility table
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5 – in vitro lipolysis procedure
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6 – guideline for preclinical studies
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What are the different types of lipid-based formulations?
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Depending on their composition, LBF exhibit different in vivo behaviors. They typically consist of biocompatible excipients falling into four main categories: oils, low-HLB surfactants, high HLB surfactants and co-solvents. To facilitate their identification, Poutonet al. introduced the Lipid Formulation Classification System based on the composition, size of the droplets generated after the dispersion of the formulation in aqueous media, and the impact of natural lipid digestion process on the in vivo performance of the formulation classes.
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What functional excipients for oral bioavailability enhancement do Gattefossé deliver?
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Our range of functional excipients includes oils, low HLB surfactants, high HLB surfactants and solvents. They can be combined to formulate all types of lipid-based formulations
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What are self-emulsifying formulations?
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Self-emulsifying lipid formulations form emulsions upon contact with aqueous fluids without the need for mechanical or thermal energy.The size of the dispersion depends on the composition of excipients in the formulation.
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How to use lipid excipients and lipid-based formulations in early stage development?
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A vehicle or formula intended for preclinical studies must allow adequate administration of the test compound with little or no effect on the test species. The vehicle or formulation must be suitable for the intended route of administration, maintain the stability of the active ingredient, and preferably, maximize the systemic bioavailability of the drug. Lipid excipients provide a solution to these challenges and have proven utility in preclinical studies. Further information is available from Gattefossé guideline
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Les lois de la gravité sont inévitables mais leurs effets secondaires sur notre peau n’ont pas à l’être. EleVastinTM est la solution à l’affaissement du visage induit par la gravité. L’ingrédient cible des protéines essentielles pour la synthèse et le maintien d’un réseau de fibres élastiques fonctionnelles. Par ce biais, il renforce l’élasticité de la peau et lui apporte le soutien nécessaire pour lutter contre cette pression vers le bas.
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Les contours du visage sont ainsi mieux dessinés, les rides verticales et profondes sont réduites et un visage d’apparence plus jeune est restauré.
EleVastinTM est issu des tiges feuillues de Murraya koenigii, une plante utilisée en médecine ayurvédique et en cuisine. La plante est récoltée sur l’île de la Réunion, sur des parcelles préservée de tout intrant (sans traitement ni pesticide).
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Grâce à l’utilisation d’un mélange de solvants d’origine végétale de type LTTM (Low Transition Temperature Mixture) et à un procédé d’extraction raisonné, un riche complexe de phyto-molécules est obtenu.
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L’ingrédient est approuvé COSMOS et affiche un contenu d’origine naturelle de 100% selon la norme ISO 16128.
Evalué sur un panel de 37 femmes présentant une peau mature, EleVastinTM limite efficacement l’impact de la gravité sur la partie basse du visage et réduit le relâchement et les rides verticales profondes.
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Dans 75% des cas, les volontaires paraissent plus jeunes à la fin de l’étude.
Soins visage: gammes anti-âge pour peaux matures, traitements dédiés aux contours du visage et V-shape, produits anti-gravité
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Soins corps: remodelant, produits sculptant
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Soins solaires: solaires avec revendications anti-âge
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\n
Le savoir-faire de Gattefossé en extraction végétale trouve son origine dans la distillation des huiles essentielles en Provence, au début du XXème siècle. Au fil du temps, l’entreprise s’est spécialisée dans la récupération sélective de molécules produites par les plantes pour fournir l’industrie cosmétique en actifs innovants et performants.
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Notre connaissance approfondie des plantes et de leurs propriétés biologiques est la base de notre travail en extraction végétale. Les chercheurs de Gattefossé s’intéressent à la fois à l’écologie, à l’ethnobotanique, aux pratiques agricoles, au génie des procédés, à la phytochimie ou à la physiologie des plantes pour sélectionner les matières premières les plus à même d’offrir des produits de qualité.
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\n
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La force et l’efficacité du végétal concentrées dans les actifs et extraits de Gattefossé
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Des années d’expérience nous ont appris à connaître, à repérer et à objectiver les molécules actives les plus intéressantes pour le soin de la peau.
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La chimie verte, l’éco-conception et la naturalité des produits obtenus sont durablement au cœur de tous nos développements. Nos ingrédients répondent aux tendances du marché de la cosmétique et aux attentes des consommateurs en termes d’innovation, sans aucun compromis sur la qualité ou sur l’efficacité.
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Un approvisionnement en matières premières exigeant et raisonné
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La qualité d’un extrait dépend de celle de sa matière première. Aussi, celle-ci s’élabore dès la plantation, par un engagement responsable qui implique tous les acteurs de la chaîne de production (agriculteur, récoltant, sécheur-conditionneur, négociant, transporteur…). Au-delà des cahiers des charges et des nécessaires mesures de traçabilité, Gattefossé se soucie depuis toujours des impacts socio-économiques et environnementaux, ainsi que de l’équité des échanges commerciaux. Nous veillons en effet à ce que notre chaine d’approvisionnement en matières premières se fasse sur une base durable et en confiance.
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Nos matières premières viennent du monde entier, dans le respect des accords internationaux, et la plupart de nos fournisseurs sont des partenaires de très longue date.
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Des procédés d’extraction à la pointe de l’innovation
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Nous adaptons nos procédures d’extraction à chaque matière première et au résultat que l’on veut obtenir. Les ingénieurs de Gattefossé sont en recherche permanente d’innovations, pour compléter la palette des techniques disponibles et des solvants encore utilisables. Solvants conventionnels, fluides supercritiques, extraction assistée par micro-ondes, toutes ces techniques sont maîtrisées dans l’entreprise et ont conduit à de nombreux produits bien connus de nos clients.
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Récemment, l’acquisition et le développement de la technique des solvants eutectiques naturels NaDES (pour Natural Deep Eutectic Solvent) ont apporté une ouverture considérable à la fabrication d’actifs hautement objectivés. Gattefossé est une entreprise pionnière sur ce sujet et nous sommes aujourd’hui à même de proposer des produits innovants, totalement naturels, à base de plantes ou de parties de plantes.
Parallèlement aux techniques d’extraction, les laboratoires de Gattefossé maîtrisent tout un ensemble de techniques séparatives, pour purifier ou concentrer les extraits. Certains de nos produits connaissent, au cours de leur fabrication, des étapes d’ultrafiltration, de nanofiltration, de distillation moléculaire ou de chromatographie basse pression.
\n
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A SG","tagline":"Sustainable texturizing","description_product_finder":"","introduction":"
Agent de texture naturel et durable, Lipocire™ A SG donne du corps aux formules cosmétiques et leur confère un toucher plus onctueux, ultra fondant.
\n
Une expérience sensorielle unique dans de nombreuses applications soin et maquillage.
Beurre végétal texturant, Lipocire™ A SG est issu de l’hydrogénation et de l’inter-estérification d’huiles de palme et de palmiste, extraites des fruits et des graines du palmier à huile. Relipidants et nourrissants, ces lipides filmogènes présentent une excellente affinité avec la peau et permettent de reconstituer le film protecteur hydrolipidique. Ils apportent douceur et confort à la peau et aux formulations.
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Gattefossé n’utilise que des huiles de palme et de palmiste certifiées RSPO Segregated (SG) (Roundtable on Sustainable Palm Oil). Cette certification garantit que les huiles proviennent exclusivement de plantations gérées durablement.
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Le fruit du palmier a la peau rouge foncé et la chair jaune-orange, il est particulièrement riche en éléments nutritifs. La pulpe du fruit et l’amande dans son noyau ont tous deux une teneur élevée en triglycérides (> 50%).
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Autres grades disponibles :
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Lipocire ™ CM SG a un point de fusion légèrement supérieur et est préconisé pour les formulations de plus grande rigidité : par exemple, sticks ou poudres pressées.
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Lipocire ™ DM SG a un point de fusion supérieur aux deux autres grades. Il est conseillé de l’utiliser pour les formulations avec une solidité encore plus grande, comme les crayons de maquillage.
Maquillage : mascaras, rouges à lèvres, brillant à lèvres, bâtons, eye-liner, ombres à paupières, rougeurs, poudres en vrac
\n
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PHARMSCI 360","date":"October 17-19","location":"Boston","type":"Booth #216","description":"Meet our Gattefossé team of experts from 17th to 19th October at American Association of Pharmaceutical Scientists (AAPS) in Boston at Booth #216 to discover our latest innovations. \r\n","button_label":"Know more","image":{"id":28123,"alt":"","title":"téléchargementaaps","caption":"","description":"","mime_type":"image/png","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/téléchargementaaps.png","width":225,"height":224,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/téléchargementaaps-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/téléchargementaaps.png","medium-width":225,"medium-height":224,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/téléchargementaaps.png","medium_large-width":225,"medium_large-height":224,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/téléchargementaaps.png","large-width":225,"large-height":224,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/téléchargementaaps.png","post-thumbnail-width":225,"post-thumbnail-height":224,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/téléchargementaaps.png","twentyfourteen-full-width-width":225,"twentyfourteen-full-width-height":224}},"link":"https://www.aaps.org/pharmsci/annual-meeting"},{"section":"pharmaceuticals","zone":"america","title":"Controlled Release Society 2022 ","date":"July 11-15, 2022","location":"Montreal Congress Center, Montreal, Canada","type":"Booth 310","description":"The Gattefossé pharma team will be present at the CRS annual meeting. The conference theme this year is “Advanced Delivery Science”, which reflects our focus on cutting-edge research and innovation across our strong discipline that will keep you up-to-date with new science and inspire new ideas.","button_label":"Register","image":{"id":27480,"alt":"","title":"Logo CRS","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/Logo-CRS.jpg","width":395,"height":393,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/Logo-CRS-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/Logo-CRS-300x298.jpg","medium-width":300,"medium-height":298,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/Logo-CRS.jpg","medium_large-width":395,"medium_large-height":393,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/Logo-CRS.jpg","large-width":395,"large-height":393,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/Logo-CRS-395x372.jpg","post-thumbnail-width":395,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/Logo-CRS.jpg","twentyfourteen-full-width-width":395,"twentyfourteen-full-width-height":393}},"link":"https://www.edgereg.net/er/Registration/StepRegInfo.jsp?ActivityID=39614&StepNumber=1&v=ODk3NTRmMTAtODI3YS00ODY5LTg3YTgtY2Y4NTM1MmMxY2Yy"},{"section":"pharmaceuticals","zone":"europe","title":"Introduction to oral BAE using lipid excipients Part III: Step-by-step development of successful lipid-based formulations","date":"July 7, 2022 - 8:30 am CET ","location":"Online ","type":"","description":"Join us to the third part of our webinar series "Introduction to oral bioavailability enhancement using lipid excipients". This webinar series will give junior formulators key information to understand how LBF address oral bioavailability issues. \r\nIn this third webinar, the methodology to develop optimized lipid-based formulations will be explained. \r\n","button_label":"Register","image":{"id":27449,"alt":"","title":"GettyImages-664495228-min","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/GettyImages-664495228-min.jpg","width":3087,"height":3083,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/GettyImages-664495228-min-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/GettyImages-664495228-min-300x300.jpg","medium-width":300,"medium-height":300,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/GettyImages-664495228-min-768x767.jpg","medium_large-width":474,"medium_large-height":473,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/GettyImages-664495228-min-1024x1024.jpg","large-width":474,"large-height":474,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/GettyImages-664495228-min-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/GettyImages-664495228-min-1038x576.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":576}},"link":"https://attendee.gotowebinar.com/register/1396133900118438160?source=WEB"},{"section":"pharmaceuticals","zone":"europe","title":"Introduction to oral BAE using lipid excipients Part II: Overview of Gattefossé excipients for oral bioavailability enhancement","date":"July 6, 2022 - 8:30 am CET ","location":"Online","type":"","description":"Join us to the second part of our webinar series "Introduction to oral bioavailability enhancement using lipid excipients". This webinar series will give junior formulators key information to understand how LBF address oral bioavailability issues. \r\nIn this second webinar, the full range of Gattefossé excipients for oral bioavailability enhancement will be detailed. \r\n","button_label":"Register","image":{"id":27445,"alt":"","title":"LABO-082","caption":"","description":"","mime_type":"image/png","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/LABO-082-1.jpg","width":2362,"height":1607,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/LABO-082-1-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/LABO-082-1-300x204.jpg","medium-width":300,"medium-height":204,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/LABO-082-1-768x523.jpg","medium_large-width":474,"medium_large-height":323,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/LABO-082-1-1024x697.jpg","large-width":474,"large-height":323,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/LABO-082-1-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/LABO-082-1-1038x576.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":576}},"link":"https://attendee.gotowebinar.com/register/6376360823013508108?source=WEB"},{"section":"pharmaceuticals","zone":"europe","title":"Introduction to oral BAE using lipid excipients Part I: Lipid-based formulations to address oral bioavailability issues","date":"July 5, 2022 - 8:30 am CET ","location":"Online","type":"","description":"Join us to the first part of our webinar series "Introduction to oral bioavailability enhancement using lipid excipients". This webinar series will give junior formulators key information to understand how LBF address oral bioavailability issues. \r\nIn this first webinar, the unique combination of benefits of lipid excipients to address oral bioavailability issues will be explained. \r\n","button_label":"Register","image":{"id":27443,"alt":"","title":"Picture","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/Picture.jpg","width":602,"height":360,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/Picture-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/Picture-300x179.jpg","medium-width":300,"medium-height":179,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/Picture.jpg","medium_large-width":474,"medium_large-height":283,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/Picture.jpg","large-width":474,"large-height":283,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/Picture.jpg","post-thumbnail-width":602,"post-thumbnail-height":360,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/Picture.jpg","twentyfourteen-full-width-width":602,"twentyfourteen-full-width-height":360}},"link":"https://attendee.gotowebinar.com/register/5242526840264937996?source=WEB"},{"section":"pharmaceuticals","zone":"europe","title":"Understanding patch composition for effective transdermal delivery","date":"June 7, 2022 - 4 pm CET - June 9, 2022 - 9 am CET ","location":"Online","type":"","description":"Join us for a complimentary one-hour webinar co-organized by Gattefossé Pharmaceuticals and DuPont™ Liveo™ Healthcare to explore the current transdermal market landscape and discover components to help you build a patch for your application - from the role of key excipients to selecting the proper adhesive.","button_label":"Register","image":{"id":27320,"alt":"","title":"16794M-17_gattefosse_300x250_ANIMATED","caption":"","description":"","mime_type":"image/gif","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/16794M-17_gattefosse_300x250_ANIMATED.gif","width":300,"height":250,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/16794M-17_gattefosse_300x250_ANIMATED-150x150.gif","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/16794M-17_gattefosse_300x250_ANIMATED-300x250.gif","medium-width":300,"medium-height":250,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/16794M-17_gattefosse_300x250_ANIMATED.gif","medium_large-width":300,"medium_large-height":250,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/16794M-17_gattefosse_300x250_ANIMATED.gif","large-width":300,"large-height":250,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/16794M-17_gattefosse_300x250_ANIMATED.gif","post-thumbnail-width":300,"post-thumbnail-height":250,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/16794M-17_gattefosse_300x250_ANIMATED.gif","twentyfourteen-full-width-width":300,"twentyfourteen-full-width-height":250}},"link":"https://attendee.gotowebinar.com/rt/5366794743348783374?source=WEB"},{"section":"pharmaceuticals","zone":"america","title":"Selection of a winning prototype formulation for challenging drugs","date":"May 25, 2022 - 11 am ET - 12 pm ET","location":"Online","type":"","description":"Join us with for a one-hour webinar where the speakers delve into guidelines for the design, characterization and differentiation of SEDDS and SNEEDS formulation systems to pick a prototype for preclinical or clinical trials.","button_label":"Register","image":{"id":27364,"alt":"","title":"GettyImages-1210343139-min","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/GettyImages-1210343139-min.jpg","width":3840,"height":2160,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/GettyImages-1210343139-min-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/GettyImages-1210343139-min-300x169.jpg","medium-width":300,"medium-height":169,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/GettyImages-1210343139-min-768x432.jpg","medium_large-width":474,"medium_large-height":267,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/GettyImages-1210343139-min-1024x576.jpg","large-width":474,"large-height":267,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/GettyImages-1210343139-min-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/GettyImages-1210343139-min-1038x576.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":576}},"link":"https://register.gotowebinar.com/register/674510124274382348"},{"section":"pharmaceuticals","zone":"europe","title":"PBP","date":"March 28-31, 2022 ","location":"Rotterdam","type":"Booth 43","description":"13th World Meeting \r\non Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology \r\n28 - 31 March 2022 | Rotterdam, The Netherlands","button_label":"Register","image":{"id":26746,"alt":"","title":"PBP WORLD MEETING","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/PBP-WORLD-MEETING.jpg","width":409,"height":384,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/PBP-WORLD-MEETING-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/PBP-WORLD-MEETING-300x282.jpg","medium-width":300,"medium-height":282,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/PBP-WORLD-MEETING.jpg","medium_large-width":409,"medium_large-height":384,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/PBP-WORLD-MEETING.jpg","large-width":409,"large-height":384,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/PBP-WORLD-MEETING-409x372.jpg","post-thumbnail-width":409,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/PBP-WORLD-MEETING.jpg","twentyfourteen-full-width-width":409,"twentyfourteen-full-width-height":384}},"link":"https://www.worldmeeting.org/home/registration/"},{"section":"pharmaceuticals","zone":"europe","title":"3D printing: One step forward to personalized medicines","date":"April 7, 2022 - 10 am CET - 5 pm CET","location":"Online","type":"","description":"In this webinar, the possibility of combining polymers and lipid excipients to develop 3D printed tablets is demonstrated. The potential to use this technology to develop multicompartment tablets for polypharmacy is highlighted. \r\nThe polymer (PVOH or PLA) is used to design the scaffold, while the lipid self-emulsifying formulations - based on Gelucire® 44/14 or Gelucire® 48/16 - are used to prepare the content, including different model drugs. \r\nThis study demonstrates the feasibility of using 3D printing and this dual polymer/lipid system to develop personalized medicines.","button_label":"Register","image":{"id":26519,"alt":"","title":"EVENT WEBINAIRE","caption":"","description":"","mime_type":"image/png","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/EVENT-WEBINAIRE.png","width":266,"height":232,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/EVENT-WEBINAIRE-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/EVENT-WEBINAIRE.png","medium-width":266,"medium-height":232,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/EVENT-WEBINAIRE.png","medium_large-width":266,"medium_large-height":232,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/EVENT-WEBINAIRE.png","large-width":266,"large-height":232,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/EVENT-WEBINAIRE.png","post-thumbnail-width":266,"post-thumbnail-height":232,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/EVENT-WEBINAIRE.png","twentyfourteen-full-width-width":266,"twentyfourteen-full-width-height":232}},"link":"https://attendee.gotowebinar.com/rt/1736929725888704272?source=Website"},{"section":"personal_care","zone":"europe","title":"In-Cosmetics Global ","date":"5-7 Avril, 2022","location":"Paris, Porte de Versaille","type":"M50","description":"Gattefossé sera présent à In-Cosmetics Global au stand M50","button_label":"Know more","image":{"id":25834,"alt":"","title":"In-Cos Global 2022","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/In-Cos-Global-2022.jpg","width":432,"height":312,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/In-Cos-Global-2022-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/In-Cos-Global-2022-300x217.jpg","medium-width":300,"medium-height":217,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/In-Cos-Global-2022.jpg","medium_large-width":432,"medium_large-height":312,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/In-Cos-Global-2022.jpg","large-width":432,"large-height":312,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/In-Cos-Global-2022.jpg","post-thumbnail-width":432,"post-thumbnail-height":312,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/02/In-Cos-Global-2022.jpg","twentyfourteen-full-width-width":432,"twentyfourteen-full-width-height":312}},"link":"https://www.in-cosmetics.com/global/en-gb.html"},{"section":"pharmaceuticals","zone":"europe","title":"Transcending transdermal delivery joined webinar Teledyne-Gattefossé","date":"November 30 and December 2nd, 2021 ","location":"webinar","type":"online","description":"Dermal drug delivery is very challenging, and numerous strategies have been developed to overcome the skin barrier. This webinar will demonstrate the importance of formulation on skin delivery, with a strong focus on solubilizers and permeation/ penetration enhancers. 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Vidéo de Vincent Hubiche, Responsable Laboratoires d'Applications Cosmétique chez Gattefossé. \r\n- Comment créer naturellement des émulsions ? 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Alphabet creams
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Skin perfectors
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Illuminating products
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Lip products (reveals natural rosy color of lips)
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Consists of esters of palmitic (C16) and stearic (C18) acids, the diester fraction being predominant
Coating agent for taste masking. Lubricant and flow aid for capsule filling with powders. Modified release matrix former for tablets. Safety of use is inferred by GRAS status and precedence of use in approved pharmaceutical products.
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Comparative evaluation of Compritol® HD5 ATO with Sodium Stearyl Fumarate and PEG 6000 as amphiphilic, hydrodispersible pharmaceutical lubricants
\n
Chhanda Kapadia and Ketkee Deshmukh
\n
J. Excipients and Food Chem. 8 (1) 2017 – 5
\n
In the present study the lubricant capacity of Compritol® HD5 ATO was compared with commonly used amphiphilic lubricants. The \n effect of the concentration and mixing time on flow properties, tablet ejection force, hardness, disintegration time and rate of dissolution of paracetamol tablets was evaluated. \n The physical properties of the lubricants such as crystallinity, wettability, thermal behaviour and surface area were also measured. \n Compritol® HD5 ATO was found to be an as effective a lubricant for a fast disintegrating paracetamol formulation containing microcrystalline cellulose, lactose and PVP prepared by wet granulation in comparison with sodium stearyl fumarate and PEG 6000.
Functional characterization of powders consisting of mixture of glyceryl behenate and a non-ionic surfactant applied by hot-melt coating: lubricant performance
\n
Jannin, V. Bérard, S. Chevrier, A. Malmazet, Y. Chavant, F. Demarne, C. Andrès
\n
Journal of Drug Delivery Science and Technology, Volume 23, Issue 2, 2013, Pages 181-185
Comparative study of the lubricant performance of Compritol®888 ATO either used by blending or by hot melt coating
\n
V Jannin, V Bérard, A N’Diaye, C Andrès, Y Pourcelot
\n
International Journal of Pharmaceutics. Volume 262, Issues 1–2, 27 August 2003, Pages 39–45
\n
In this study, the lubricant performance of Compritol 888 ATO is assessed in a classical blending process or by hot melt coating. The results suggest that the hot melt coating process induces an homogeneous repartition of the lubricant on the lactose surface, \n contrary to classical blending procedure. Thus, lubrication by hot melt coating seems to be a very efficient procedure. It could be used specifically for large surface area particulate systems producing a lot of friction.
Comparative study of the lubricant performance of Compritol® HD5 ATO and Compritol® 888 ATO: effect of polyethylene glycol behenate on lubricant capacity
\n
A. N’Diaye, V. Jannin, V. Bérard, C. Andrès, Y. Pourcelot
\n
International Journal of Pharmaceutics. Volume 254, Issue 2, 26 March 2003, Pages 263–269
\n
In this study the lubricant capacity of Compritol HD5 ATO is compared to Compritol 888 ATO. It shows that mixing lubricants with Lactopress present no structural differences and that they have equivalent compressibility and cohesiveness. This study concludes \n that Compritol HD5 ATO could be a very interesting excipient because it associates the glyceryl dibehenate lubricant capacity with the polyethylene glycol property of enhanced dissolution.
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Formulating cosmetic preparations often means combining materials that are not very compatible while creating a strong sensorial identity. Now imagine an emulsifier that could not only help solve a wide range of formulating problems but also confer a soft, velvety feel. Answering formulators’ needs for a high-performance emulsifier, Gattefossé has developed an original combination of nonionic products, offering exceptional emulsifying power and a heightened sensorial experience : Emulium® Delta MB.
Excellent stability—incorporates easily into formulations ranging in pH from 3 to 13
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Stabilizing difficult actives
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Exceptional compatibility with a wide range of oils and active ingredients
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Easy to formulate—process-independent, adapted to one-pot process, making it easy and painless to go from lab to production.
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Excellent emulsifying and stabilizing properties
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Velvet touch
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“With sensory analysis you are able to understand why a cream is preferred amongst others. You can see exactly which criteria are different, this helps to create better products to answer consumer needs.”
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20+ years of sensory expertise
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At Gattefossé we understand well that texture is the key to the success of a cosmetic product. With that in mind we developed our own in-house sensory analysis panel in 1996. This team of trained experts, led by Vincent Hubiche, evaluates the sensory attributes of our ingredients, prototypes and market formulations.
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What is sensory analysis?
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Sensory analysis is a scientific discipline used to measure, analyze and interpret the characteristics of a product as they are perceived by the five senses. Our team of trained experts focuses mainly on the sense of touch. They have gone through intense training and can identify and quantify product attributes such as softness, greasiness and spreadability. With the data from the panel, we create sensory profiles which allow us to compare one or more formulations or use Principal Component Analysis to compare many more.
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Meet the man behind the sensory panel
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Watch the video below to hear Vincent Hubiche explain more about sensory analysis and how it drives innovation in personal care.
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Become a sensory expert
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Our knowledge in sensory is something we gladly share with customers. We offer large sensory seminars and even smaller customized trainings to teach chemists and product developers to properly evaluate formulations. If you are interested in receiving sensory training, please contact your local Gattefossé representative.
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A nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs. Self-emulsifies in aqueous media forming a coarse dispersion, i.e., emulsion (SEDDS). Co-emulsifier in topical formulations to improve stability of emulsions.
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Oleoyl polyoxyl-6 glycerides
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Oleoyl macrogol-6 glycerides
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DRG3KJZ1TJ
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APRICOT KERNEL OIL PEG-6 ESTERS
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Polyoxylglycerides
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Consists of mono-, di- and triglycerides and PEG-6 (MW 300) mono- and diesters of oleic (C18:1) acid
Solubilizer for poorly-soluble API and bioavailability enhancer Single excipient formulation system: self-emulsifies in aqueous fluid into emulsion – LFCS type II (SEDDS) Combine with Labrasol®ALF or Gelucire® 44/14 for LFCS Type III (SMEDDS) Co-emulsifier in topical formulations often associated with Tefose® 63 in antifungal cream Safety of use is supported by substantial toxicological data and precedence of use in approved pharmaceutical products.
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When powder properties are unsuitable for direct compression, a granulation step is required to improve compactibility, flow, and content uniformity.
\n
Lipid excipients are commonly used in two granulation techniques to modify drug dissolution, either as sustained-release or wetting agents:
\n
\n
wet granulation—where the solid lipid excipient is used in the powder blend or incorporated into the binder solution
\n
melt granulation—where the lipid excipient acts as a binder between the solid particles (ingredients are blended as temperature is brought gradually up to the lipid melting point to form granules)
\n
\n
\n
Advantages of lipid excipients in wet granulation:
\n
\n
organic solvent–free process
\n
water-insoluble atomized powders prevent swelling and sticking during granulation
\n
waxy, water-dispersible Gelucires incorporated into aqueous binder solution
\n
easy cleaning of equipment and tooling
\n
\n
Advantages of lipid excipients in melt granulation:
\n
\n
solvent-free process
\n
high binding capacity, yielding resistant granules
\n
flexible process, suitable for high shear mixer, melt extruder, and fluid bed granulator
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Création
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En 1880, Louis Gattefossé fondait la société en France.
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Cet entrepreneur avant-gardiste a toujours privilégié le développement de relations solides avec ses clients et a toujours encouragé la curiosité, une qualité qui devait s’avérer précieuse pour l’avenir de l’entreprise.
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Parfums et essences
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Par la suite, c’est son fils René-Maurice Gattefossé qui a dirigé la société.
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Inventif et visionnaire, il a apporté sa rigueur scientifique à l’entreprise.
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Créateur de parfums, de senteurs et inventeur de l’aromathérapie, il a marqué l’histoire de Gattefossé par sa pensée futuriste.
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Extraction végétale et partenariats scientifiques
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C’est ensuite le fils de René-Maurice, Henri-Marcel Gattefossé, qui a pris sa succession et développé l’entreprise en ajoutant l’extraction végétale au catalogue de ses activités.
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Passionné par les sciences et par les travaux de ses pairs, il a travaillé en étroite collaboration avec des chercheurs des hôpitaux et des universités du monde entier. Grâce à ses contacts scientifiques, Henri-Marcel a par la suite créé l’Académie des Alpilles-également connue grâce aux Journées Galéniques de St-Rémy de Provence– qui offre l’opportunité de partager ses connaissances avec la communauté scientifique mondiale.
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Cette institution, reconnue à l’échelle internationale est placée sous l’égide de la Fondation Gattefossé. Elle est toujours en activité plus de quarante ans après sa création.
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Lipochimie
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Emile Mahler, ingénieur et chimiste créatif, a rejoint la société en 1937, lors de son mariage avec la fille de René-Maurice.
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Dans les années qui ont suivi, son travail sur les lipides, les technologies d’émulsion et leurs applications dans le développement de formules a beaucoup influencé le développement sur le long terme et les orientations de la société.
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Le savoir-faire actuel de Gattefossé en matière de lipochimietrouve ses origines dans le travail et dans les études d’Émile Mahler.
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Défis les plus récents
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Ces dernières décennies, notre société a été confrontée à l’évolution rapide de son environnement et a dû répondre aux exigences de plus en plus nombreuses de ses clients : qualité, innovation, respect réglementaire et recherche de différenciation.
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Sous la houlette de Jacques Moyrand, notre groupe s’est résolument préparé pour l’avenir et a évolué afin de relever ces défis et de développer de meilleures relations clients.
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Des filiales de distribution ont été ouvertes dans l’ensemble des principales régions (Amérique du Nord, Europe occidentale et Asie). Notre groupe est désormais présent dans 60 pays grâce à un réseau significatif d’agents et de distributeurs.
\n","box_links":[{"link":"https://www.gattefosse.com/fr/foundation/foundation-master/","title":"Fondation Gattefossé","external_link":"","image":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/03/prix-aroma-innovations-cliniques.jpg"},{"link":"https://www.gattefosse.com/fr/corporate-map/locations/","title":"Où nous trouver","external_link":"","image":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/07/gattefosse-worldwide_medium.jpg"}],"useful_links":[],"":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"introduction":"D’abord fournisseur de matières premières pour la parfumerie, Gattefossé s’est orientée vers la fabrication et la commercialisation d’ingrédients cosmétiques dans les années 1930 et d’excipients pharmaceutiques dans les années 1950, non sans avoir démontré entre-temps les vertus thérapeutiques des huiles essentielles. Résolument ancrée à Lyon, l’entreprise a toujours été ouverte sur le monde. Après avoir implanté des filiales de distribution puis des sites de production à l’étranger, elle affiche aujourd’hui une identité multiculturelle forte. \r\n \r\nCette section est consacrée au récit chronologique de l’entreprise, qui débute en 1880 à Lyon.","left_blocks":[{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/05/gattefosse-140.png","title":"140 ans d'esprit scientifique : le site web ","description":"Plongez au cœur des 140 ans d'histoire de Gattefossé","link":"https://www.gattefosse.com/fr/corporate-content/gattefosses-140-years-website/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/05/gattefosse-history-1880-1918.jpg","title":"1880 à 1918","description":"Notre histoire de 1880 à 1918","link":"https://www.gattefosse.com/fr/corporate-content/gattefosse-history-1880-to-1918"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/05/gattefosse-history-1919-1950.jpg","title":"1919 à 1950","description":"Notre histoire de 1919 à 1950","link":"https://www.gattefosse.com/fr/corporate-content/gattefosse-history-1919-to-1950/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/05/gattefosse-history-1951-1975.jpg","title":"1951 à 1975","description":"Notre histoire de 1951 à 1975","link":"https://www.gattefosse.com/corporate-content/gattefosse-history-1951-to-1975/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2020/05/gattefosse-history-1976-2020-1.jpg","title":"1976 à 2020","description":"Notre histoire de 1976 à 2020","link":"https://www.gattefosse.com/corporate-content/gattefosse-history-1976-to-2020/"}]},"_links":{"self":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages/19188"}],"collection":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/comments?post=19188"}],"version-history":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages/19188/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/media?parent=19188"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/categories?post=19188"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/tags?post=19188"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"press":{"id":15521,"date":"2019-05-29T09:44:24","date_gmt":"2019-05-29T07:44:24","guid":{"rendered":"https://www.gattefosse.com/?page_id=15521"},"modified":"2021-06-08T15:50:36","modified_gmt":"2021-06-08T13:50:36","slug":"press","status":"publish","type":"page","link":"https://www.gattefosse.com/kobo-products/corporate-expertise/press/","title":{"rendered":"Press"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Media and press section | Official pictures and press releases | Gattefossé","_yoast_wpseo_metadesc":"In this section, you can find the more recent press releases, pictures and videos published by Gattefossé and its Foundation."},"categories":[30],"tags":[],"acf":{"component":"PageExpertiseCorpo","oneLoad":false,"title":"Welcome to our press area","content":"
We thank you for your interest in our company. In this section, you can find the more recent press releases, pictures and videos published by Gattefossé and its Foundation.
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Do you have any questions? We would be happy to answer your media inquiries.
Gattefossé develops, manufactures and sells specialty ingredients for thepersonal care and pharmaceutical industries and offers a strong expertise in formulation for both of these activities.
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Gattefossé markets its products in more than 60 countries through 12 affiliated companies and a network of agents and distributors who provide technical and marketing support.Innovation, ethics, quality and long-term stability are the company key-drivers since the beginning.
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Gattefossé was founded in Lyon, France in 1880 by Mr. Louis Gattefossé to whom building strong relationship with customers was a priority. The company remains a family-run, independent business, and now employs more than 300 people worldwide.
\n","box_links":[{"link":"https://www.gattefosse.com/kobo-products/corporate-expertise/our-expertise/","title":"Our expertise","external_link":"","image":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/07/our-expertise-288x164px.jpg"}],"useful_links":[{"text_link":"Gattefossé on Twitter","link":false,"external_link":"https://twitter.com/GattefosseGroup"},{"text_link":"Gattefossé on Linkedin","link":false,"external_link":"https://www.linkedin.com/company/gattefosse"},{"text_link":"Gattefossé on Youtube","link":false,"external_link":"https://www.youtube.com/channel/UCUTYQ7BQ4odr5tvtsiReMlg"}],"":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"introduction":"We thank you for your interest in our company. In this section, you can find the more recent press releases, pictures and videos published by Gattefossé and its Foundation. \r\n \r\nDo you have any questions? We would be happy to answer your media inquiries through our contact form.","left_blocks":[{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/press-releases.jpg","title":"Press releases","description":"Download our latest press releases.","link":"https://www.gattefosse.com/corporate-content/press-releases/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/about-gattefosse.jpg","title":"About Gattefossé","description":"Gattefossé at a glance.","link":"https://www.gattefosse.com/corporate-content/press-about-gattefosse/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/official-pictures-1.jpg","title":"Official pictures","description":"The official pictures of our President and CEO.","link":"https://www.gattefosse.com/corporate-content/press-official-pictures/"}]},"_links":{"self":[{"href":"https://www.gattefosse.com/kobo-products/wp-json/wp/v2/pages/15521"}],"collection":[{"href":"https://www.gattefosse.com/kobo-products/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/kobo-products/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/kobo-products/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/kobo-products/wp-json/wp/v2/comments?post=15521"}],"version-history":[{"href":"https://www.gattefosse.com/kobo-products/wp-json/wp/v2/pages/15521/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/kobo-products/wp-json/wp/v2/media?parent=15521"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/kobo-products/wp-json/wp/v2/categories?post=15521"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/kobo-products/wp-json/wp/v2/tags?post=15521"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"locations":{"id":1209,"date":"2017-03-16T09:29:48","date_gmt":"2017-03-16T09:29:48","guid":{"rendered":"http://217.109.87.212/front/?page_id=1209"},"modified":"2023-07-11T16:43:57","modified_gmt":"2023-07-11T14:43:57","slug":"locations","status":"publish","type":"page","link":"https://www.gattefosse.com/corporate-map/locations/","title":{"rendered":"Interactive map"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Locations | where to find your Gattefossé nearest representative","_yoast_wpseo_metadesc":"With more than 60 countries covered, we provide an extensive network of technical and marketing teams at your service. Don't hesitate to contact us!"},"categories":[51],"tags":[],"acf":{"title":"OUR AFFILIATES AND DISTRIBUTORS WORLWIDE","description":"One of the driving forces behind Gattefossé’s development is its global presence. With a responsive and highly trained sales network, we offer our customers strong service with a local approach specific to their markets. To find the Gattefossé representative nearest you, please refer to the map below. \r\n \r\nClick on the pins to display information. Click and hold the left mouse button down to drag the map.","":false,"collaborators":[{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Algeria","name":"Gattefossé Mediterranean","event_link":"https://www.gattefosse.com/corporate-events/events/","position":{"address":"Dar El Beïda alger","lat":"36.710817033128436","lng":"3.228515626396984"},"production_site":"Gattefossé Mediterranean","address":"Dar el Baida, \r\nAlger, \r\nAlgeria","description":"","image":false,"zone":"africa_middle_east","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Brazil","name":"Gattefossé do Brasil","event_link":"https://www.gattefosse.com/corporate-events/events/","position":{"address":"","lat":"-23.497382874338456","lng":"-46.84701204299927"},"production_site":"Gattefossé do Brasil","address":"Alameda Grajau 129 cj 604 – Alphaville \r\nBarueri, SP 06454050 \r\nBRAZIL \r\n \r\n+55 11 2970-1010 \r\n","description":"
Gattefossé Group created Gattefossé Do Brasil in 2012, a worldwide affiliate located in São Paulo. The objective of this entity is to reinforce Gattefossé’s presence in Latin America, a growing market and a place for opportunities for both personal care and pharmaceutical ingredients. Lead by Mrs Amanda Botelho Pimentel, Gattefossé Do Brasil supports Gattefossé’s distributors in this promising territory, and facilitates contacts with all customers in Latin America. With the help of both its pharmaceutical and personal care distributors, Gattefossé has now the capacity to support its customers more efficiently, by making its technical and marketing expertise locally available to its customers.
\n","image":false,"zone":"america","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Canada","name":"Gattefossé Canada ","event_link":"https://www.gattefosse.com/corporate-events/events/","position":{"address":"","lat":"43.68848838417244","lng":"-79.58850145339966"},"production_site":"Gattefossé Canada Inc. ","address":"190 Attwell Drive, Suite 600 \r\nToronto, ON \r\nM9W 6H8 \r\n \r\n+1 416 243 5019","description":"
Gattefossé Canada Inc. was established in 1997 to service Personal Care, Pharmaceutical and Nutraceutical industries in Canada. Since its creation, this unit has demonstrated key competencies to growing the presence of Gattefossé as provider of innovative solutions involving its performance ingredients. Under the leadership of Eric Brun, Ph.D., our specialized team (marketing and technical support, customer service) is fully committed to servicing our customers from our locations (offices and warehouses) in Montreal and Toronto.
\n","image":false,"zone":"america","website":""},{"section":["personal_care","pharmaceuticals","application_laboratory"],"type":"affiliate","country":"China","name":"Gattefossé China ","event_link":"https://www.gattefosse.com/corporate-events/events/","position":{"address":"","lat":"31.02234042904364","lng":"121.7669677734375"},"production_site":"Gattefossé China Trading Co. Ltd","address":"Room 5301, Building No. 5, \r\nLane 338, Galileo Road, \r\nPudong District, SHANGHAI \r\nCHINA \r\n \r\n+86 21 5895 8010","description":"
\n","image":false,"zone":"asia_pacific","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"France","name":"Gattefossé France","event_link":"https://www.gattefosse.com/corporate-events/events/","position":{"address":"","lat":"48.885159995263706","lng":"2.261037289572414"},"production_site":"Gattefossé France","address":"Gattefossé France \r\nImmeuble Kastle \r\n2 Ter, Rue du Château \r\n92200 Neuilly-Sur-Seine \r\nFrance \r\n \r\n+33 1 41 47 19 00","description":"
Créé en 1993 et adapté aux spécificités du marché français, Gattefossé France a toujours marqué sa volonté de s’engager aux côtés de ses clients en allant au-delà de son rôle de fournisseur de matières premières. Gattefossé France a notamment structuré son offre de manière à allier intimement besoins en formulation et démarche créative, pour accompagner cosmétologues et galénistes dans la globalité de leurs problématiques.
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Les ingrédients Gattefossé, issus de savoir-faire en oléochimie et extraction biologique, ciblent les besoins clients aussi bien en cosmétique qu’en pharmacie humaine et vétérinaire. \n Les polymères texturants de Lubrizol Life Science et les esters de sucrose émulsifiants de Mitsubishi Chemicals complètent efficacement cette offre sur le territoire français.
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Sous la direction de Thierry Magnet, une équipe dynamique d’une vingtaine de personnes de formations pluridisciplinaires met tout en œuvre pour satisfaire les exigences de ses interlocuteurs, chercheurs et marketeurs. Sa priorité ? Transformer vos idées en produits pertinents.
Die Gattefossé Deutschland GmbH betreut seit 1989 Kunden der Kosmetik- und Pharmaindustrie in Deutschland und Österreich. Die deutsche Vertriebsniederlassung befindet sich in Eschbach im Gewerbepark Breisgau, der zentral im Dreiländereck Deutschland-Frankreich-Schweiz liegt.
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In Ergänzung zu den eigenen innovativen Produkten der Gattefossé-Gruppe vertreiben wir im Kosmetikbereich Rohstoffe unserer langjährigen Geschäftspartner Lubrizol und Mitsubishi.
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Das Gattefossé-Team verfügt über eine umfassende Expertise und unterstützt Sie bei der Realisierung Ihrer Pharma- und Kosmetik-Projekte. Wir teilen mit unseren Kunden unser anwendungstechnisches Know-how und garantieren eine vertrauensvolle und partnerschaftliche Zusammenarbeit.
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Gattefossé erkennt die Trends von morgen und entwickelt immer wieder neue Produkte und Marketingkonzepte. Die Bedürfnisse unserer Kunden stehen im Vordergrund.
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Das Gattefossé-Team freut sich über Ihren Anruf oder Ihre Email an: infode@gattefosse.de
\n","image":false,"zone":"europe","website":""},{"section":["personal_care","pharmaceuticals","application_laboratory"],"type":"affiliate","country":"India","name":"Gattefossé India","event_link":"https://www.gattefosse.com/corporate-events/events/","position":{"address":"","lat":"19.071948827022688","lng":"72.87676692008972"},"production_site":"Gattefossé India Pvt Ltd","address":"Equinox Business Park \r\nTower 3, 3rd floor, \r\nOff Bandra Kurla Complex, \r\nLBS Marg, MUMBAI- 400 07 \r\nINDIA \r\n \r\n+91 22 61 36 80 00","description":"
Gattefossé India is a decade run strategic supplier for cosmetics and pharmaceuticals companies in India. This Gattefossé affiliate is responsible for sales, marketing and technical service support throughout the Indian subcontinent. It sustains a profitable operation, supported by a professional team of business development, technical and customer service as well as administration managers. Gattefossé India extends extensive regulatory, toxicological support, technical and application guidance to the pharmaceutical and personal care customers. Various workshops, texture showcase and seminars are organised by experts for detailing benefits of Gattefossé products.
\n","image":false,"zone":"asia_pacific","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Italy","name":"Gattefossé Italia ","event_link":"https://www.gattefosse.com/corporate-events/events/","position":{"address":"","lat":"45.5059935026097","lng":"9.1636423766613"},"production_site":"Gattefossé Italia S.R.L.","address":"Via G. Durando 38 \r\nI-20158 MILANO MI \r\nITALY \r\n \r\n+39 02 49 54 29 50","description":"
Gattefossé Italia è stata fondata nel 1960 per servire le Industrie Cosmetiche e Farmaceutiche Italiane. Dalla sua creazione, questa filiale ha conosciuto una costante crescita, dimostrando di possedere le competenze giuste per consolidare Gattefossé quale fornitore di soluzioni innovative, con ingredienti sempre più efficaci. Il nostro team di specialisti (marketing, tecnici, customer service), totalmente dedicato al servizio dei nostri clienti, opera dai nostri uffici di Milano col pieno supporto dei nostri Uffici e Laboratori Centrali di Lione e Parigi.
\n","image":false,"zone":"europe","website":""},{"section":["personal_care","pharmaceuticals","production_site"],"type":"affiliate","country":"Singapore","name":"Gattefossé Asia Pacific","event_link":"https://www.gattefosse.com/corporate-events/events/","position":{"address":"","lat":"1.3310498636538042","lng":"103.74185800552368"},"production_site":"Gattefossé Asia Pacific Pvt Ltd","address":"8 Jurong Town Hall Road \r\nThe JTC Summit, Unit 28-04 \r\nSINGAPORE 609434 \r\n \r\n+65 63 16 63 12","description":"
Gattefossé Asia Pacific, Singapore regional office is one of the latest setup within the Gattefossé group. The new entity with a core team of technical and commercial staff reinforces Gattefossé’s presence in the Asia Pacific region. The Singapore regional office works closely with distributors and logistics partners in the marketplace. The company identifies the need to evolve its operations to gain more speed and efficiency by making inroads into the South East Asian countries, Japan, South Korea, Taiwan as well as Australia and New Zealand. This enables Gattefossé to effectively service the customers in terms of technical support and commercial requirements for both Personal Care and Pharmaceutical businesses in this important region.
\n","image":false,"zone":"asia_pacific","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Spain","name":"Gattefossé España ","event_link":"https://www.gattefosse.com/corporate-events/events/","position":{"address":"","lat":"40.431099512795356","lng":"-3.671826124191284"},"production_site":"Gattefossé España S.A.","address":"C/Padilla, 73, 1°B \r\n28006 MADRID \r\nSPAIN \r\n \r\n+34 9 1 402 13 11 / 1612","description":"","image":false,"zone":"europe","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Tunisia","name":"Gattefossé Mediterranean ","event_link":"https://www.gattefosse.com/corporate-events/events/","position":{"address":"","lat":"36.84457343098993","lng":"10.275282561779022"},"production_site":"Gattefossé Mediterranean SCI","address":"Immeuble les Emeraudes, bloc A \r\nAvenue de la Bourse \r\nLes Jardins du Lac II \r\n1053 Tunis \r\nTUNISIA \r\n \r\n+ 216 71 192 401 / 402","description":"
The Gattefossé Mediterranean affiliate is led by Mr Fayçal El Aouni and has its regional hub in Tunis. This affiliate allows the group to consolidate its presence in North Africa and the Middle East by marketing its products to customers directly as well as offering technical support and expertise to local distributors. With this regional organisation, Gattefossé is strengthening its presence among pharmaceutical and cosmetics companies in these countries by offering them the benefit of its formulation expertise.
Gattefossé UK was established in 2001 to service Personal Care and Pharmaceuticals industries in the United Kingdom and Ireland. Since its creation, this unit has enjoyed a permanent growth and has demonstrated key competencies to growing the presence of Gattefossé as provider of innovative solutions involving its performance ingredients. Our specialized team of professionals (marketing and technical support, customer service) is fully committed to servicing our customers from our Corporate Office in Berkshire. Gattefossé UK also distributes Personal care ingredients from Lessonia and Mitsubishi.
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The USA and Canadian affiliates of Gattefossé (created respectively in 1982 and 1997) were established to provide local service and support to the.pharmaceutical and personal care industries in North America. Since its creation, Gattefossé North America has enjoyed continuous growth, expanding its presence as a provider of innovative solutions involving performance ingredients. Under the leadership of Eric Brun, Ph. D, a specialized team of professionals, including marketing, customer service, supply chain, quality, and technical support, is fully committed to servicing customers from the corporate offices in Paramus, NJ, Toronto, ON and Montreal, QC. Local service is also provided by long-term partners in the US Midwest and West Coast, as well as Mexico. Today, Gattefossé has 34 employees and 3 offices in North America as well as 3 warehouses in Edison (NJ), La Mirada (CA) and Toronto (Canada).
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Emulium® Dolcea MB est un émulsionnant H/E sans PEG, 100% d’origine naturelle, facile à formuler et flexible qui crée des textures fluides comme des beurres épais.
\n
Emulium® Dolcea MB est parfaitement compatible avec les ingrédients cosmétiques et apporte une excellente stabilité en combinaison avec des agents gélifiants naturels.
\n
Avec son pouvoir hydratant immédiat et long-terme, cet ingrédient apporte de la fonctionnalité et de l’efficacité à une large gamme d’applications.
\n
Doté d’une signature sensorielle forte, il apporte une douceur extrême aux émulsions cosmétiques. Approuvé COSMOS, Emulium® Dolcea MB peut être utilisé dans des formulations certifiées bio, véganes et facilement biodégradables.
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Gattefossé a poussé les limites de sa technologie brevetée des beurres de cires pour développer la version la plus aboutie et robuste de ses émulsionnants naturels, Emulium® Dolcea MB.
\n
Les cires de jojoba et de tournesol utilisées dans Emulium® Dolcea MB réagissent avec du polyglycérol végétal pour créer un émulsionnant H/E 100% d’origine naturelle, qui apporte des propriétés hydratantes grâce aux cires végétales et une identité sensorielle unique.
Emulium® Dolcea MB peut être ajouté à la phase huileuse de préférence, ou à la phase aqueuse si nécessaire. Robuste, il est capable d’émulsionner et de stabiliser des émulsions contenant jusqu’à 40% de phase huileuse. Sous forme de pastilles, il est très facile à utiliser, ne nécessite pas d’agitation forte et permet la création d’émulsions très fines (5-10µm).
Avec Emulium® Dolcea MB, notre émulsionnant naturel le plus robuste, plusieurs process peuvent être utilisés pour répondre à différentes contraintes. Regardez cette vidéo pour découvrir chacun d’eux ainsi que leurs bénéfices !
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Pouvoir hydratant immédiat et long-terme:
\n
\n
Améliore significativement l’hydratation de la peau comparé à un émulsionnant avec PEG
\n
La peau est hydratée jusqu’à 48 heures
\n
Le niveau d’hydratation de la peau est amélioré sur l’ensemble du visage
\n
\n
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Biodégradabilité :
\n
\n
La composition d’Emulium® Dolcea MB a été soigneusement choisie pour assurer une excellente biodégradabilité
\n
97% de la crème testée contenant Emulium® Dolcea MB a été biodégradée après seulement 28 jours
\n
\n
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\n
Le plus robuste de la gamme des émulsionnants naturels de Gattefossé
\n
Facile à mettre en oeuvre en laboratoire et en production
\n
Hydratation intense et durable
\n
Apporte une douceur extrême
\n
Crée des formulations facilement biodégradables
\n
\n
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\n
Textures fluides à beurres épais
\n
Soin de la peau
\n
Maquillage
\n
Solaire
\n
Formulations certifiées bio, véganes et facilement biodégradables
\n
\n
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Founded in Lyon, France, in 1880, Gattefossé is a leading provider of specialty ingredients and formulation solutions for the beauty and health care industries worldwide. Our history is built on our founders’ deep commitment to sustainability, innovation, and service. Specialists in lipid chemistry and plant extraction, we create effective natural actives and functional lipid excipients. We work diligently to guarantee the quality and reliability of our ingredients while providing our customers with all the support and resources they need to make successful products that address global consumers’ demands.
For nearly 140 years, our strategy of continuous investment in research, development, and applications has driven our capacity to innovate. Gattefossé customers benefit from the company’s unique know-how and ability to stay one step ahead of market trends in the personal care and pharmaceutical sectors.
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This expertise has extended throughout the years to other complementary fields with the aim to develop, produce and market first-class products and services of a consistently high quality, while leading the way for innovation and creativity. \r\n \r\n","":false,"component":"PageExpertiseCorpo","left_blocks":[{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/03/industrial-operations_322x173px.jpg","title":"Industrial operations","description":"A solid know-how, state-of-the-art technologies and a constant commitment to quality.","link":"https://www.gattefosse.com/corporate-content/industrial-operations/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/03/plant-extraction_322x173px.jpg","title":"Plant extraction","description":"High-quality actives based on plant extraction processes.","link":" https://www.gattefosse.com/corporate-content/plant-extraction/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/03/lipid-chemistry1_322x173px.jpg","title":"Lipid chemistry","description":"We design functional ingredients for the personal care and pharmaceutical industries.","link":"https://www.gattefosse.com/corporate-content/lipid-chemistry/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/03/skin-biology_322x173px-3.jpg","title":"Skin biology","description":"Our skin biology laboratory develops cell culture models.","link":"https://www.gattefosse.com/corporate-content/skin-biology/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/03/applications_322x173.jpg","title":"Applications","description":"Our four technical center of excellence aim at providing technical support to our customers.","link":"https://www.gattefosse.com/corporate-content/applications/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/03/regulatory-affairs_322x173px.jpg","title":"Regulatory affairs","description":"We pay constant attention to maintaining the level of our regulatory expertise.","link":" https://www.gattefosse.com/corporate-content/regulatory-affairs/"}],"title":"Our expertise","content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/935"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=935"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/935/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=935"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=935"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=935"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"hot-melt-extrusion":{"id":2924,"date":"2017-04-25T09:27:16","date_gmt":"2017-04-25T09:27:16","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=2924"},"modified":"2021-04-07T10:47:35","modified_gmt":"2021-04-07T08:47:35","slug":"hot-melt-extrusion","status":"publish","type":"page","link":"https://www.gattefosse.com/pharmaceuticals-content/hot-melt-extrusion/","title":{"rendered":"Hot Melt Extrusion"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Excipients for hot melt extrusion | Gattefossé","_yoast_wpseo_metadesc":"Discover our range of low extrusion temperature functional excipients to provide extended release, solubility enhancement or taste masking properties."},"categories":[49],"tags":[],"acf":{"component":"PageGenericContentPharma","title":"Hot Melt Extrusion","content":"
Hot melt extrusion is a continuous solvent-free technology with precise process control. Lipid excipients are mainly used as matrix formers for modified release, or as solubilizers for solubility/bioavailability enhancement, alone or in combination with polymers.
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Advantages of lipid excipients in hot melt extrusion:
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low melt viscosity, resulting in low torque
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low extrusion temperatures (30–75 °C)
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low melting point and instant solidification, thereby avoiding downstream cooling
In a collaborative study with the University of Austin, Gattefossé investigated hot melt extrusion using polyvinylpyrrolidone (PVP) as the polymer and Compritol® 888 ATO as the plasticizer and sustained-release agent. The study showed that Compritol® improves the processability of PVP dispersions, reducing extrusion torque and increasing yield.
\n","box_links":[{"link":false,"title":"Tech Chat","external_link":"https://youtu.be/p8SAdfV6s2k","image":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/tech-chat8-322x216-1.jpg"}],"useful_links":[{"text_link":"Access our publications","link":"https://www.gattefosse.com/pharmaceuticals-special-content/publications-on-hot-melt-extrusion/","external_link":""},{"text_link":"Watch our lab scale extruder demo","link":false,"external_link":"https://youtu.be/CT33vHgSVLs"}],"":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"introduction":"","application_description":"","application_image":false,"oral_application_items":[],"topical_application_items":[],"rectal_application_items":[],"process_formulation_description":"","process_formulation_image":false,"oral_process_formulation_items":[],"topical_process_formulation_items":[],"rectal_process_formulation_items":[]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/2924"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=2924"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/2924/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=2924"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=2924"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=2924"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"our-commitments":{"id":15319,"date":"2019-05-28T15:31:47","date_gmt":"2019-05-28T13:31:47","guid":{"rendered":"https://www.gattefosse.com/?page_id=15319"},"modified":"2022-02-08T15:51:18","modified_gmt":"2022-02-08T13:51:18","slug":"our-commitments","status":"publish","type":"page","link":"https://www.gattefosse.com/corporate-expertise/our-commitments/","title":{"rendered":"Commitments"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Gattefossé commitments | Quality ingredients and responsible innovation","_yoast_wpseo_metadesc":"At Gattefossé, we foster innovation and deliver high-quality products that help build customer brands, while reducing our environmental impact."},"categories":[30],"tags":[],"acf":{"component":"PageExpertiseCorpo","title":"Commitments","introduction":"We embrace our responsibility towards the planet, our customers, and stakeholders. We want to make a difference by sharing knowledge to foster innovation and deliver high-quality products that help build customer brands, while reducing our environmental impact.","":false,"content":[{"wysiwyg":"
Quality and Security
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For Gattefossé, quality is a strategic driver for progress which is fully integrated in every process we undertake, from research to product delivery to our customers. Our quality policies are constantly upgraded to meet and even exceed our customers’ expectations. We are regularly audited by all our major customers, and strive to continuously improve our quality standards, as demonstrated by well-prized certifications.
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Our industrial site at Saint-Priest is ISO 9001 certified since 1993.
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An average of 20 customer audits are carried out per year on our Saint-Priest site.
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Our products have obtained several certifications, following guidelines such as ECOCERT, COSMOS, National Organic Program, etc.
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Since 1990, we have been a member of the Responsible Care Program, the chemical industry’s global voluntary initiative for the protection of the environment.
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Good Manufacturing Practices
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We always comply with applicable Good Manufacturing Practices (GMPs) for both our pharmaceutical and personal care ingredients.
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As an active member of the International Excipient Council (IPEC), we have aligned our quality system with the joint IPEC/PQG GMP Guide for Pharmaceutical Excipients.
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We are also an active member of the European Federation for Cosmetic Ingredients (EFfCI), and our quality system complies with the EFfCI GMP Guide for Cosmetic Ingredients.
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Safety
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As part of its group management policy, Gattefossé has implemented safety actions to prevent and counter the risks associated with its activities—manufacturing, supply chain, logistics, and R&D—and facilities—production lines, application laboratories, and office buildings. Particular attention has been given to training and campaigns to raise awareness. Appropriate indicators and action plans are routinely defined and applied. Committed to quality and safety, we ensure our procedures apply a frame of reference we share with our customers—in terms of systems, standards, and industry regulations.
\n"},{"wysiwyg":"
Corporate Social Responsibility
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Environment
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To foster responsible innovation, production processes have been modernized to conserve energy, generate less waste, and maximize recyclability.
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For many years, Gattefossé has been committed to sustainable development, significantly reducing energy consumption while increasing its manufacturing capacity.
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The company protects the environment by carefully selecting raw materials of natural origin for its production processes. As such, Gattefossé became a member of RSPO in 2010, to support conscientious and responsible palm oil producers and cooperatives. In 2017, the company achieved RSPO Mass Balance certification applied to its manufacturing site in France. Gattefossé also uses certified segregated palm and palm kernel oil for its Lipocire™ range of personal care ingredients.
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Gattefossé ensures that raw materials come from safe, identifiable, and renewable sources. Its tracking system monitors origins and methods of production. The company establishes long-term relationships with suppliers, who we consider to be strategic partners.
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People Development
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We are convinced that the future growth of our company depends on the talented people we employ worldwide, truly committed to making Gattefossé a global player. The group is proud of its strong corporate culture, influenced by the characters of its founders and leaders. They have driven the development of the company while remaining faithful to its original code of ethics.
Gattefossé has developed strong relationships with the international scientific community and shares its knowledge through publications, seminars, and conferences. The company supports doctoral students and runs contract research projects with various academic groups worldwide.
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Lesjournées galéniques of Saint-Rémy de Provence
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Organized by the Gattefossé Foundation, the Journées Galéniques of Saint-Rémy de Provenceis a science conference where researchers and university professors gather to discuss the latest developments in pharmaceutical science. The event seeks to promote advanced knowledge and techniques related to the formulation of medicines by encouraging dialogue between scientists from academia and industry that is centered on pharmaceutical technology.
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By organizing these meetings, Gattefossé is pursuing the work initiated in the 1960s by Henri-Marcel Gattefossé, who envisioned a company that would foster the flow of ideas between researchers worldwide.
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The proceedings of the Journées Galéniques are published in the form of a Bulletin Technique* available to all parties in the field of pharmaceutical technology.
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\n"}],"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"left_blocks":[{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/actionplan-2020-commitments.jpg","title":"CSR action plan","description":"Our concrete, socially responsible commitments towards the environment and our people.","link":"https://www.gattefosse.com/corporate-content/csr-action-plan-2"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/human-rights-vignette.jpg","title":"Human Rights commitments","description":"Our commitments to Human Rights, integrity, responsibility and respect for all our partners.","link":"https://www.gattefosse.com/corporate-content/gattefosse-human-rights-commitments/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/customer-oriented.jpg","title":"Customer oriented","description":"Building long-term partnerships based on trust and loyalty.","link":"https://www.gattefosse.com/corporate-content/customer-oriented/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/quality-security.jpg","title":"Quality and security approach","description":"For Gattefossé, quality and security are strategic drivers for progress.","link":"https://www.gattefosse.com/corporate-content/quality-security-approach/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/sharing-knowledge.jpg","title":"Knowledge sharing","description":"Gattefossé shares its knowledge through publications, seminars, and conferences.","link":"https://www.gattefosse.com/corporate-content/knowledge-sharing/"},{"visual":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/gattefosse-foundation.jpg","title":"Gattefossé Foundation","description":"Promoting the scientific and clinical use of essential oils.","link":"https://www.gattefosse.com/foundation/foundation-master"}],"events":[]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/15319"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=15319"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/15319/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=15319"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=15319"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=15319"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"csr-action-plan-2":{"id":22816,"date":"2021-01-22T17:18:03","date_gmt":"2021-01-22T15:18:03","guid":{"rendered":"https://www.gattefosse.com/?page_id=22816"},"modified":"2022-02-09T13:13:54","modified_gmt":"2022-02-09T11:13:54","slug":"csr-action-plan-2","status":"publish","type":"page","link":"https://www.gattefosse.com/corporate-content/csr-action-plan-2/","title":{"rendered":"CSR action plan"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":19,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"Discover our concrete, socially responsible commitments towards the environment and our people."},"categories":[48],"tags":[],"acf":{"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"component":"PageGenericContentCorporate","title":"Our CSR roadmap","content":"
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Combine sustainable growth and general interest
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Environmental, social and societal issues have always been part of the Gattefossé culture. When we talk about Corporate Social Responsibility (CSR), our vision is to lead together the transition to a business model that combines sustainable growth and general interest.
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Which means, being profitable, committed and innovative \n while having a positive impact on the environment and civil society
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This objective is at the heart of our CSR roadmap:
Acting ethically day-to-day and engaging our local communities to the common good
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“Over the past few years, our CSR approach has been developed and structured so that it is now at the heart of our development strategy. We consider CSR as a growth lever, a source of opportunity and innovation. Through Gatt’Up & Act, we would like to engage all our stakeholders to act in the service of the common good and general interest. I believe in the strength of the collective and that is how we will make a difference.” Ségolène MOYRAND-GROS, President of the Gattefossé Group
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A recognized CSR performance
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Awarded Platinum by EcoVadis
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Since 2017, our CSR approach is assessed by the world’s largest and most trusted provider of business sustainability ratings, EcoVadis. In 2021 we obtained the highest level of recognition “Platinum” with a score of 74/100, ranking Gattefossé in the TOP 1% of EcoVadis evaluations!
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To know more about the detailed results of this 2021 assessment, do not hesitate to request access to the following account in the EcoVadis website: Gattefossé SAS (Saint-Priest site).
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ISO 14001:2015 certification
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After two years of work, Gattefossé obtains in October 2021 the ISO 14001:2015 certification for its main production site in Saint-Priest (France). A certificate validated from the first audit by the certification body SGS.
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\n","useful_links":[]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/22816"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/19"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=22816"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/22816/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=22816"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=22816"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=22816"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"gattefosse-history-1880-to-1918":{"id":19191,"date":"2020-05-18T11:11:45","date_gmt":"2020-05-18T09:11:45","guid":{"rendered":"https://www.gattefosse.com/?page_id=19191"},"modified":"2020-09-23T15:13:10","modified_gmt":"2020-09-23T13:13:10","slug":"gattefosse-history-1880-to-1918","status":"publish","type":"page","link":"https://www.gattefosse.com/corporate-content/gattefosse-history-1880-to-1918/","title":{"rendered":"Gattefossé’s history: 1880 to 1918"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Gattefossé's history: 1880 to 1918","_yoast_wpseo_metadesc":"1880-1906: Louis Gattefossé and Sons. 1907-1918: Perfume and Aromatics."},"categories":[48],"tags":[],"acf":{"component":"PageGenericContentCorporate","title":"Our history: 1880 to 1918","content":"
1880-1906: Louis Gattefossé and Sons
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The story of Gattefossé began in 1880 when a 26-year-old Louis Gattefossé (see picture) moved to Lyon with his wife Marie-Eugénie and their two children, Abel and Marie-Louise. Louis had been managing a beer warehouse further north in Vesoul (the Haute-Saône region of France) but had just been recruited as a salesman for Seghers & Maréchal, a Lyon-based oilcloth manufacturer. Louis’s sales portfolio steadily expanded beyond oilcloth to include photographic paper, petroleum jelly, mineral waxes and oils derived from petrol. And soon he was carrying a set of sample products, most of which were created through chemical processes, and would later be used as raw materials in Gattefossé products.
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In 1894, Louis began forging relationships with perfume houses at the Exposition Universelle (international colonial exhibition) in Lyon that year. From that point on, he started selling citrus essential oils from Sicily, terpene-free essences from Germany and Switzerland, and cosmetic raw materials manufactured by German and Belgian companies. He also started preparing “aromatic compositions” for his perfumer clients: Eaux de Cologne, “crèmes divines” and cold creams, jotting down the formulations in a little notebook. Louis’s company may not have been established yet, but his preparations marked the start of Gattefossé’s manufacturing activity.
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In 1895, Abel Gattefossé turned 18 and began working with his father. Louis’s second son, René-Maurice, joined them some fifteen years later after studying Chemistry at the University of Lyon. René-Maurice was responsible for research and production in the company “laboratory”, which at that point was a simple lean-to in the garden of the family home in Monchat, a district on the outskirts of Lyon. Abel and Louis were both in charge of sales, however in 1906, Louis retired, leaving the management of the business to his two eldest sons.
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1907-1918: Perfume and Aromatics
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In January 1907, Abel and René-Maurice created “Gattefossé & Fils” (Gattefossé & Sons), and the family business was legally recognized as a French company for the very first time. Both sons continued their father’s work, with Abel running the commercial side of the business and René-Maurice in charge of research. René-Maurice was keen to let his clients know about the use of synthetic fragrances (new to the market and often criticized), and he published several very successful books.
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René-Maurice was also interested in “natural” raw materials, especially essential oils. In 1907, the President of the South-East Agricultural Trade Union wanted to raise the profile of French lavender and invited René-Maurice to Haute Provence to see the “baïassières”, the region’s vast wild lavender fields. There, René-Maurice discovered a piece of unclaimed land and also met lavender growers working in basic conditions. He soon put initiatives in place to improve product quality, increase yield, modernize equipment, educate producers and organize the profession to make it more effective. He made sure that the stills functioned more efficiently, filed for a patent, contributed to creating a trade union for lavender essence producers, purchased a steam distillation plant, set up a cooperative for lavender growers and lots more. These initiatives were helpful to the Gattefossé business as a major user of essential oils, but they also proved to be profitable: the price of lavender per kilo rose from 14 Francs in 1907 to 48 Francs in 1914, with production increasing at the same rate.
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Inspired by the success of his investment in Provençal lavender, in 1908 René-Maurice (on the picture in the laboratory in 1904) launched La Parfumerie Moderne, a trade magazine targeted at perfumers, essence producers, engineers and agronomists. La Parfumerie Moderne may have promoted the interests of the whole sector, but it also functioned as an indirect communication tool for the Gattefossé business, giving it a higher status than a company of its size would ordinarily enjoy. In fact, at the outbreak of the First World War, the company had around ten employees.
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The three Gattefossé brothers – Abel, René-Maurice and Robert, Louis’s third son – were all enlisted. Of the three, only René-Maurice would survive. In 1915, René-Maurice was wounded and returned to the business, throwing heart and soul into promoting essential oils, which he believed could save lives at a time so tainted by death.
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It was in 1910 that René-Maurice personally experimented with the antiseptic properties and healing qualities of lavender essential oil. After an explosion in his laboratory, René-Maurice developed gas gangrene on both hands and decided to apply lavender essence to the infected wounds. They healed, so he started to study this new “therapy”. In 1916, he developed Salvol, an “aromatic disinfectant” that would go on to be trialed in hospitals, first with soldiers, then civilians during the Spanish flu pandemic of 1918. Now he had the support of medics, René-Maurice was keen to prove the benefits of using terpene-free essences which, according to him, were more soluble in water than untreated oils. This marked a significant step forward in the history of aromatherapy.
A partially anionic oil-in-water emulsifier for topical formulations. It enables the formulation of anhydrous emulsions for hydrosensitive APIs and emulsions with solvents or large amount of oily phase.
\n","names_kv":[{"keys":"USP NF Name","value":"
Mixture of Triceteareth-4 phosphate and Ethylene glycol palmitostearate and Diethylene glycol palmitostearate
\n"},{"keys":"EP Name","value":"
Mixture of Triceteareth-4 phosphate and Ethylene glycol palmitostearate and Diethylene glycol palmitostearate
\n"},{"keys":"UNII Code (FDA)","value":"
/ 0324G66D0E 94YQ11Y95F
\n"},{"keys":"Preferred Substance Name (FDA)","value":"
/ GLYCOL STEARATE PEG-2 STEARATE
\n"},{"keys":"Handbook of Pharmaceutical Excipients","value":"
Ethylene Glycol Palmitostearate
\n"},{"keys":"Chemical description","value":"
Consits of a mixture of triceteareth-4 phosphate, ethylene glycol esters of palmitic (C16) end stearic (C18) acids and diethylene glycol esters of palmitic (C16) end stearic (C18) acids
Emulsifier for anhydrous topical formulations. Emulsifier for difficult-to-formulate emulsions (solvents and large oily phase). Stabilizes and improves sensorial and texture properties. Safety of use is inferred by precedence of use in approved pharmaceutical products.
\n","main_formulation_technologies":"
Topical emulsion and foam (with aerosol). One-pot formulation process can facilitate manufacturing.
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Active pharmaceutical ingredients (APIs) exhibiting low aqueous solubility or poor intestinal permeability will be associated with poor or variable drug absorption. Lipid-based drug delivery (LBDD) has emerged as a successful approach to improve drug solubilization in the dosage form and, more importantly, in the gastrointestinal (GI) tract, leading to normalized drug absorption and increased bioavailability.
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Lipid excipients have proven utility for BCS Class II APIs and are potentially useful for Classes III and IV, due to their ability to:
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improve API solubility in the dosage form;
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maintain APIs in a solubilized state within the GI tract;
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work in synergy with in vivo physiological lipid digestion and absorption, which facilitate drug absorption.
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Lipid excipients: Solubilizers of poorly water-soluble drugs
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Drug solubility depends on many physicochemical properties and is therefore a complex phenomenon. When addressing poor aqueous solubility, a drug molecule is often described as lipophilic or hydrophobic. Lipophilic molecules are insoluble in aqueous solution but exhibit a degree of solubility in lipid excipients. In contrast, hydrophobic molecules are insoluble in aqueous solution and can also be poorly soluble in lipids (i.e., hydrophobic/lipophobic).
\n
The lipophilicity of an API is described as the log P value, which can be a useful starting point in selecting lipid excipients for solubility screening.
Lipide excipients should be able to solubilize APIs in the dosage form, and it is crucial that they maintain API solubility in vivo when exposed to an aqueous environment. Therefore, the behavior of the excipients in aqueous fluid is an important factor.
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The hydrophilic/lipophilic balance (HLB) is commonly used to categorize the degree of affinity of the lipid excipient for the aqueous phase. At Gattefossé, the HLB of excipients is determined by analytical methods and called practical HLB.
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\n
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Each API has a complex chemical space. As such we recommend solubility screening of the API for a range of excipients. Depending on API characteristics, one or more lipid excipients may be required to solubilize the target dose. Generally, excipients that provide the highest solubilizing power are selected for formulation development. For information about formulation, consult our section“Lipid-based drug delivery systems.”
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Lipid excipients maintain APIs in solubilized state during digestion
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Digestive enzymes play a well-known role in food transformation within the GI tract. They digest fats (triglycerides) by the hydrolysis of ester bonds, which releases free fatty acids and monoglycerides. These are naturally emulsified by bile salts into mixed micelles and transported to the GI membrane for absorption. Lipid excipients comprise fatty acid esters (e.g., glycerides and PEG esters) and are therefore subject to lipolysis by the same endogenous enzymes.
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The in vivo digestion of lipid excipients can further enhance drug solubility in mixed micelles, presenting the drug in a solubilized state at the GI membrane.
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Lipid excipients naturally promote drug absorption
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With lipid-based formulations, API bioavailability may be improved by:
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facilitating drug permeability through the intestinal epithelium;
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stimulating chylomicron secretion, which results in enhanced drug uptake through the lymphatic pathway, bypassing initial metabolism in the liver.
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Medium chain lipids (C<12) diffuse across the enterocyte directly into blood vessels. Long unsaturated chain lipids (C18:1, C18:2) are absorbed via the lymphatic pathway.
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Learn how basic human needs can optimize the function, health, and appearance of the skin."},"categories":[56],"tags":[],"acf":{"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"component":"PageGenericContentCos","blocks":[],"main_img_article":{"id":29261,"alt":"","title":"Hacking Skin Health - Main Image Article_1536x510","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2023/05/Hacking-Skin-Health-Main-Image-Article_1536x510.jpg","width":1536,"height":510,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2023/05/Hacking-Skin-Health-Main-Image-Article_1536x510-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2023/05/Hacking-Skin-Health-Main-Image-Article_1536x510-300x100.jpg","medium-width":300,"medium-height":100,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2023/05/Hacking-Skin-Health-Main-Image-Article_1536x510-768x255.jpg","medium_large-width":474,"medium_large-height":157,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2023/05/Hacking-Skin-Health-Main-Image-Article_1536x510-1024x340.jpg","large-width":474,"large-height":157,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2023/05/Hacking-Skin-Health-Main-Image-Article_1536x510-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2023/05/Hacking-Skin-Health-Main-Image-Article_1536x510-1038x510.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":510}},"title":"Hacks to a Healthy Glow","description":"3 Must-Haves for Skin & Survival","content":"
Human survival relies on three fundamental needs: nourishment (food and water), air, and shelter. We cannot survive without these essentials, and neither can our skin! How can we package these into personal care products for optimized function, health, and appearance of skin?
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Stay Hydrated
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Did you know that humans can survive up to one month without food but only three days without water? (1) That is because all the major bodily systems, like thermal regulation, joint lubrication, organ and tissue protection, circulation, nutrient absorption, and waste removal, depend on water to function and survive. (2)
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What about the skin?
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Water makes up the majority of skin composition. So, being our largest, most external organ, it is easy to recognize when skin is dehydrated: complexion appears duller, more tired with deeper dark circles, and fine lines and wrinkles are more visible. On the contrary, skin appears more radiant, plumper, and smoother when sufficiently hydrated. But drinking 8 cups of water is not enough to fix this. You need to add a moisturizer to your daily routine too!
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We recommend Emulium® Dermolea MB as the O/W emulsifier to bring a clinically proven moisturizing effects to your personal are products. Tested in South Africa on Black and Brown skins, Emulium® Dermolea MB brings immediate and long-lasting moisturization after a single application.
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And in China, we tested the same formulation on medium skin tones and proved its capacity to moisturize for 28 days and up to 48hrs after the last application.
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\n Just Breathe
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Gary Brecka, human biologist and founder of Grant Cardone 10X Health Systems, recommends practicing mindful breathwork to achieve optimal health, as “the presence of oxygen is the absence of disease.” Oxygen is necessary to sustain healthy cellular activity and energy production. And the more you properly oxygenate, the more power you generate. (3)
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What about the skin?
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A healthy subcutaneous vascular network is necessary to provide the oxygen needed for a refined, illuminating complexion. We recommend adding Gatuline® Radiance to your skincare products for its complementary vasorelaxation and stimulated microcirculation efficacy. Skin texture, luminosity, and color are all improved for a healthier glow and a more uniform appearance.
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Derived from the Wu-Zhu-Yu fruit used for centuries in Traditional Chinese Medicine, Gatuline® Radiance was also tested in the highly polluted areas of China on sensitive skins, proving to reduce redness and minimize pore appearance.
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Build-A-Barrier
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Humans need shelter for security, personal safety, and protection from weather, disease, and external dangers. So would you prefer one built of straw, sticks, or bricks?
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What about the skin?
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The stratum corneum (SC), the outermost layer of skin, needs a strong structure because it protects the skin from the external environment. Known as the skin barrier, it has a brick-and-mortar design essential for survival. If compromised, the skin is more prone to external aggressors, water loss, inflammation, and skin sensitivity.
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To ensure a reinforced skin barrier, we recommend Gatuline® Renew. This J-Beauty-inspired active accelerates cell renewal by boosting essential proteins needed at every step and epidermal layer. It also increases ceramide synthase-3 (CerS3) mRNA expression, which favors lipid biosynthesis for a stronger and more cohesive permeability barrier. And when the skin barrier is compromised, Gatuline® Renew accelerates its recovery within four days, as opposed to six. \n
Oily phase for topical formulations. Oily vehicle and solubilizer for solutions. Safety of use is inferred by substantial toxicological data and precedence of use in approved human and veterinary pharmaceutical products.
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Foams can be produced using two distinct technologies:
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In an aerosol using propellant gas, the formulation consists of an emulsion. The creamy foam obtained is suitable for damaged or sensitive skin (e.g., psoriasis or atopy).
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In a propellant-free device, the formulation consists of a microemulsion. The light texture obtained is suitable for quick absorption without residue and is convenient for hair-bearing skin. It may, for example, be used with disinfectant or anti-inflammatory drugs.
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Excipients for propellant device emulsion formulation:
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Tefose® 63 is an O/W emulsifier with foaming capacity and high mucosal tolerance. It is often used in combination with Labrafil® M 1944 CS as a co-emulsifier and Transcutol® P as solvent.
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Excipients for propellant-free device micro-emulsion formulation:
Gattefossé can provide formulation tips for pharmaceutical foams using propellant and propellant-free devices, guidelines on how to formulate and select excipients, and case studies with model drugs.
Oily vehicle in LFCS Type I, Type II (SEDDS), and Type III formulations (SMEDDS). Oil phase for topical formulations. Oily vehicle and solubilizer for solutions. Safety of use is inferred by food additive status and precedence of use in approved pharmaceutical products.
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Definicire® is an active texturizing agent that recreates the hair protective lipid layer. 100% natural, based on functionalized jojoba and sunflower seed waxes, it ensures perfect hair discipline in all climates, and a comfortable smooth feel.
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\n","use_level":"2%","naturalite":"Worldwide approval for cosmetic applications \r\nListed on IECIC (Inventory of Existing Cosmetic \r\nIngredients in China) 2015 \r\nCOSMOS approved \r\nPatent pending","inci":"Jojoba Esters (and) \r\nHelianthus Annuus (Sunflower) Seed Wax (and) \r\nPolyglycerin-3","origin":"
Silicones and quaternary compounds are the main cosmetic ingredients used as hair conditioners. They are both efficient, in different ways, but have limitations regarding biodegradability, build-up effect and image. In addition, they are not natural and are unlike the complex hair lipid layer.
\n
Gattefossé has placed its expertise in lipid chemistry at the service of haircare. \n Definicire® is a unique ingredient obtained by transesterification of jojoba wax and sunflower seed wax in presence of polyglycerol. Its composition has been optimized to recreate the performance of sebum and 18-MEA which are known to provide naturally the best protection of the hair.
Healthy hair is hydrophobic. Definicire® reinforces the hydrophobicity of the hair. It acts as a lubricant decreasing friction between hair fibers and improves hair quality in both dry and humid conditions.
Ensures hair discipline: frizz and volume control, curl definition even under high humidity
\n
Inhibits the effect of static electricity
\n
Facilitates combing
\n
Enhances hair smoothness
\n
Protects from pollution
\n
\n
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\n
Rinse-off conditioners and masks
\n
Pre-style treatments
\n
After-style: anti-frizz day creams, protective hair sprays and lotions
\n
Men’s lines: beards, styling gums and waxes
\n
\n
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During tablet and capsule production, lubricants are necessary to improve powder flow and reduce friction and adherence. Lubrication is a critical step since over- or underlubrication is responsible for many production and quality issues. Therefore, lubricant type, quantity, and conditions of use are critical parameters to take into account when developing a formulation.
\n
\n
Advantages of Gattefossé lubricants:
\n
Gattefossé lubricants are recommended for challenging formulations. They are also able to resolve production and quality issues due to these qualities:
\n
\n
chemical inertness: no reactive groups and no incompatibility with APIs or other excipients
\n\n
robustness: resistant particles of homogeneous size ensure constant surface area; mixing time and speed do not change the quality of the lubrication or tablet properties
\n\n
effective lubrication that preserves tablet attributes: hardness, disintegration time, and drug release
improved powder blend flow due to glidant properties
\n
recommended for use at proportion 1%–3% (w/w)
\n
GRAS status and precedence of use with many APIs (FDA IID)
\n
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A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms.
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Polyglyceryl-3 dioleate
\n"},{"keys":"EP Name","value":"
/
\n"},{"keys":"UNII Code (FDA)","value":"
XRQ165498B
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Polyglyceryl-3 oleate
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/
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Consists of polyglyceryl-3 esters of oelic acid (C18:1), the diester fraction being predominant.
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulations. Safety of use is inferred by precedence of use in approved pharmaceutical products.
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In the footsteps of Emile Mahler, Gattefossé has developed unique, respected expertise in lipid chemistry over the last 70 years. We design and manufacture functional ingredients for the cosmetic and pharmaceutical industries.
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\n
Lipid chemistry is a relatively simple science with a long history. It is built around well-known esterification, trans-esterification, and hydrogenation reactions. Sophisticated process engineering and fine analytical characterization yield products with desirable properties. These are artfully combined to prepare unique ingredients for the cosmetic and pharmaceutical industries.
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Responsible chemistry attentive to social and environmental impact
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Our lipid chemistry is based on the transformation of vegetable oils, waxes, and fatty acids. Gattefossé has long been committed to a responsible sourcing of raw materials. In addition to being a member of the Round table on Sustainable Palm Oil (RSPO), the company supports cooperatives and oil producers involved in sustainable production processes. The raw materials that make up our cosmetic ingredients are all certified “mass balance” or “segregated.”
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Functional and sensorial properties for pharmaceutical or cosmetic applications
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Innovation in the use of lipid ingredients is largely based on experience. The first functional cosmetic ingredient, developed in the 1980s, was a beeswax texturizer. Two decades later, after extensive forays in the field of analytical chemistry, the original product technology was combined with the synthesis and transformation of several natural waxes to create a unique and effective new offering:Emulium® Mellifera. Gattefossé’s latest launch for cosmetic applications, it received the Gold Innovation Award at in-cosmetics Global 2014 for its exceptional qualities as both texturing agent and active ingredient.
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For the cosmetic market, Gattéfossé offers a range of lipid ingredients:
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\n
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surfactants
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emollients
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texturizing agents
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stabilizers
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products falling into more than one of the above categories
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These ingredients may be used to give substance to body care, skin care, or hair care products, or they can be incorporated into makeup or sun protection formulas.
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For the pharmaceutical market, our company produces several kinds of excipients:
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surfactants
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lubricants
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solubilizers
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compression agents
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They are used to solubilize and carry APIs, improve and regulate their bioavailability, or mask their taste. Our extended range of excipients allows for oral, cutaneous, rectal, vaginal, or mucosal drug administration. Naturally, all Gattefossé excipients meet the quality criteria of pharmacopoeias worldwide.
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We continuously test our ingredients in formulations. Our application laboratories and sensorial panel work with our customers from the cosmetic and pharmaceutical industries during the formulation process to ensure our products always fit their needs. This dialogue between chemists and formulators facilitates development and fosters creativity.
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Robust processes for superior quality
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The quality of our excipients is based on the proven technology delivered by our research and manufacturing teams. Our industrial capabilities are constantly improving, often under the impetus of our research and development teams. For example, a winterization unit has been added to our set of synthesis equipment for the production of new pharmaceutical excipients.
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Our scientists are always honing their skills in fields as eclectic as analysis, enzymatic catalysis, molecular distillation, and extrusion. Their connection to a larger scientific network and participation in national and international initiatives ensure Gattefossé remains at the level of excellence on which it has stood for decades.
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Ready-to-use stabilizing agent for bi-gels
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Mixture of Propylene glycol monolaurate NF, Ethylcellulose NF and Propylene glycol isostearate
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Propylene glycol monolaurate
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Ethylcellulose
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Emulsions are, by definition, unstable systems and require a surfactant. To enable simple formulation of stable emulsion system, Gattefossé offers a range of self-emulsifying bases consisting of all-in-one excipients. Due to their specific compositions combining lipophilic and hydrophilic surfactants with texture agents, they provide stable emulsions whatever the type and concentration of oil.
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Emulsions are traditionally produced by separately preparing oily and aqueous phases and then mixing them together. Critical process parameters are temperature, blade type, mixing speed and duration, and cooling conditions. Emulsions with Gelot™ 64 are obtained in this way.
\n
\n
A one-pot process is an interesting alternative whereby all ingredients are mixed in a single step. This is achievable with a powerful emulsifier like Tefose® 63 at a minimum concentration of 12%.
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A cold process might be necessary for heat-sensitive drugs. In such cases, the best emulsifier is Plurol® Diisostearique, which permits formulation at room temperature.
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Emulsification is obtained when mixing and heating yield enough energy to disperse the oil droplets in the aqueous phase, or vice versa. Thus, to obtain a stable emulsion, mixing conditions need to be carefully defined during development and scale-up.
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Our formulators have worked on scale-up—from lab- to pilot-scale production—with different formulations and equipment.
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Ask for our Dermacare brochure \n
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As the skin ages, a progressive disorganization of the dermal structure occurs and is responsible for reduced firmness and tonicity. Face and body contours lose their definition, décolleté and neck areas become wrinkled.
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Gatuline® In-Tense MB is an active ingredient of natural origin that acts deeply in the skin, in the extra-cellular matrix. By stimulating fibroblasts’ activity, it provides support to the collagen fiber network and restores firmness and smoothness of the face and the body.
Gatuline® In-Tense MB is a concentrated oily extract taken from the flower of the Acmella Oleracea plant also called Paracress or “Brède mafane”, a traditional spicy condiment. Acmella Oleracea is renowned for its high content in alkylamides, markers of the plant activity.
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Special attention is given to a selective harvest of the flowers (upper buds only), so that the plant can be used by local population for other applications, especially for cooking.
Stimulates the biomechanical functions of the fibroblasts
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Reduces wrinkled appearance of the face and neck
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Facial care: day and night lines, anti-aging, anti-wrinkles, facial contour remodeling
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Body care: firming, body sculpting
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Make up: firming foundations, replumping lipsticks
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Safety first!
\n
Gattefossé guarantees high quality and purity excipients for the utmost safety.
From 2 to 4 mm diameter, mini-tablets are ideal for children as they are very easy to swallow.
\n
Sustained-release mini-tablets are difficult to formulate due to the short diffusion pathway of the matrix. Compritol® 888 ATO, a well known sustained-release agent, was shown to provide reproducible release of drugs in mini tablets, using levadopa and theophyllin as model drugs.
\n
There is precedence of use of glyceryl dibehenate as SR agent with guanfacine hydrochloride to treat Attention Deficit Hyperactivity Disorder, in mini-tablets at 1, 2, 3 or 4 mg.
\n"},{"wysiwyg":"
Taste masking
\n
Children are very sensitive to bitterness, due to a higher number of specific buds on the tongue. Therefore masking the taste of drugs is essential for pediatric medicines.
\n
Coating technologies with lipid excipients enable the formation of a film coat around the drug particles to mask their taste. The coated drug particle is further used for granules, tablets and capsules.
\n
High shear coating is achieved in a high shear mixer, without external heating, and partial melting of Precirol® ATO 5. This simple, efficient and robust process was successfully used with KCl, isoniazid, paracetamol and ranitidine HCl as model drugs.
Children skin is thin and sensitive and requires specific care, with very well tolerated dosage forms, hence excipients.
\n
We provide emulsifiers with high mucosal tolerability such as Tefose® 63 and Plurol® diisostearique suitable for a wide range of pediatric formulations.
\n
Ask for our formulation for nappy rash with zinc oxide and Plurol® diisostearique, a PEG-free water-in-oil emulsifier.
Rectal route of administration is particularly interesting for new borns (from 1 month old) and in emergency for unconscious or vomiting children.
\n
When adminstering to infants and toddlers it is compulsory to adapt the unit size to the body weight. Therefore suppositories are available at different dosage levels or as breakable units. Suppocire® NAI 25 A was shown to provide content uniformity in both parts of breakable suppositories.
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Emulium® Mellifera MB is the first ever O/W emulsifier that auto-adapts to skin type and to climate, draping the skin in an invisible film that protects from environmental extremes.
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Created and formulated by teams across the world, Emulium® Mellifera MB creates light and smooth textures of great beauty and finesse. When the skin feels good, the results are visible. Moisturization, radiance, skin texture and smoothness, Emulium® Mellifera MB brings the guarantee of younger and healthier looking skin.
\n
Emulium® Mellifera MB brings a sensory solution to global consumer expectations, bringing delight upon application and visible efficacy.
Emulium® Mellifera MB is created from natural ingredients using green chemistry. Beeswax and Jojoba wax are reacted with vegetable polyglycerol. This transforms their texture to yield a soft and homogeneous butter with active properties.
Emulium® Mellifera MB contains functionalized plant waxes that leave a soft, barely perceptible film on the surface of the skin. This film plays a key role in helping the skin adapt to the environment.
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In nature, waxes are known to protect plants from dehydration and without them many species could not survive the seasons. Emulium® Mellifera MB brings this protecting role to the skin.
May be used on sensitive and hyperreactive skin (clinically tested)
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Fully flexible skin care textures
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Textures of Asian inspiration
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Color capture cosmetics
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Sun care—high SPF lotions and creams with a light feel
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Natural and organically certified formulations
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Touch and feel are important factors when buying beauty and personal care products. Consumers attach great importance to the texture and comfort of a formulation. Their enjoyment of a given texture encourages use and repurchase, creating a connection between product and consumer.
\n
Today’s consumer also wants to be surprised and charmed by skin care products. Textures that offer something unusual create a unique experience for the user.
\n
Emulium® 22 MB gives consumers this subtle surprise that they are looking for.
\n
An O/W emulsifier, Emulium® 22 MB creates fine, elegant emulsions with a transforming skin feel. While products formulated with Emulium® 22 MB look thick and rich in the jar, they are surprisingly light to the touch, with a long play time, light after-feel, and matte finish.
Emulium® 22 MB has a long behenic chain (C22) and yields nontacky, nongreasy emulsions that leave only a very light residual film—even when used with UV filters.
Emulium® 22 MB may be used for a range of viscosities, from lotion to cream.
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Sensory profile:
\n
\n
bright, creamy, rich appearance
\n
excellent pick-up
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evanescent feel (light and thin)
\n
easy spreading and rapid absorbency
\n
nongreasy, nontacky after-feel
\n
matte finish and little film residue
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Properties:
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Ideal for sun care and make-up applications, Emulium® 22 MB:
\n
\n
works well with sunscreens, pigments, lotions, and supple creams
\n
yields fine emulsions and optimal dispersion
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Excellent stability
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Refined touch
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Fine emulsions
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Skin care—all skin types, for day and night applications
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","protected":false},"excerpt":{"rendered":"
\n","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"2020 annonce une année particulière pour Gattefossé : celle de son 140ème anniversaire. "},"categories":[41],"tags":[],"acf":{"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"display_on_language_version":"both","title":"Plongez au cœur des 140 ans d'histoire de Gattefossé","description":"2020 annonce une année particulière pour Gattefossé : celle de son 140ème anniversaire. L’occasion pour notre entreprise de revenir sur les faits marquants de son histoire au travers d’un site internet qui s’y consacre.","date":"27.05.2020","content":"
\n
Nous vous le proposons dans un contexte inédit : le COVID-19 sévit et met à l’épreuve les Hommes et ses organisations, faisant écho à de nombreuses épreuves surmontées par le passé.
\n
\n
\n
Cette plongée au cœur de l’histoire de Gattefossé nous aide à trouver les points d’accroche nécessaires en cette période. Elle nous permet aussi d’apprécier l’audace des décisions prises dans des circonstances comparables, qui ont permis à Gattefossé d’être, à 140 ans, un acteur international des mondes de la pharmacie et de la cosmétique.
Solubilizer and O/W surfactant for microemulsion. Able to form light foams with pump device (no gas required). Safety of use is inferred by extensive toxicological evaluations and precedence of use.
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Renew","tagline":"Uncover perfection","description_product_finder":"","introduction":"
Symbols of perfect beauty, Japanese women are renowned for the quality of their skin and consider in depth moisture as the secret to skin perfection.
\n
\n
All over the world, women are inspired by the Japanese ideal. The desire to obtain healthy and pure skin represents a new beauty paradigm where beauty is expressed without artifices and the skin must reflect its perfection naturally.
\n
\n
Guided by this new beauty philosophy, Gattefossé developed Gatuline® Renew. It kick-starts the cell renewal process and strengthens the barrier function. The skin is visibly more hydrated, softer and smoother both to the eyes and to the touch. Reflecting light better, the skin reveals all its natural beauty.
A natural extract of handpicked Japanese cedar buds, Gatuline® Renew is rich in energetic phytochemicals that stimulate epidermal renewal.
\n
\n
Native to Japan, the Japanese cedar (Cryptomeria japonica) has been transplanted to the Reunion Island. The plant thrives on the island, where Gattefossé sources the buds used in Gatuline® Renew.
\n
\n
\n
\n
A responsible sourcing: Japanese cedar buds are picked by hand. To ensure the longevity of the trees, only their lower branches are cut.
Boosts all essential steps of epidermis renewal and strengthens stratum corneum
\n
Improves the desquamation
\n
Restores a functional skin barrier
\n
Promotes proper water homeostasis
\n
Enhances skin surface aspect
\n
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\n
Acts throughout the epidermis, from the basal layer to surface corneocytes
\n
Favors hydration from within
\n
Prevents dehydration
\n
Smoothes the skin, making it softer, more supple and comfortable
\n
Enhances global skin quality and appearance
\n
Adapted to sensitive skin (clinical test under dermatological control)
\n
\n","applications":"
\n
Skin perfectors
\n
Skin smoothing treatments
\n
Moisturizing solutions
\n
Night regeneration creams
\n
Alphabet creams
\n
Natural make up products
\n
Body care lines
\n
\n","actives":["complexion","moisturizing"],"actives_secondary":["natural","preservative_free","alcohol_free"],"textures":"","textures_secondary":"","extract":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/1648"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=1648"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/1648/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=1648"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=1648"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=1648"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"pharma-hub":{"id":932,"date":"2017-03-06T14:02:54","date_gmt":"2017-03-06T14:02:54","guid":{"rendered":"http://217.109.87.212/front/?page_id=932"},"modified":"2022-03-24T14:45:37","modified_gmt":"2022-03-24T12:45:37","slug":"pharma-hub","status":"publish","type":"page","link":"https://www.gattefosse.com/pharmaceuticals-expertise/pharma-hub/","title":{"rendered":"Pharma 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Gattefossé has built a solid scientific reputation with its functional excipients and their drug development applications. Continuous R&D investment and employment of highly qualified scientists demonstrate our commitment to providing customers worldwide with quality technical support.
\n
In 1960, we established our first R&D and Applications laboratories at our French headquarters. Since then we have opened three new Technical Centers of Excellence in key pharmaceutical markets:
The main aims of these centers are: \n • to provide customer technical support \n • to characterize and optimize the performance of excipients in drug delivery systems and processes \n • to share knowledge through education and training.
\n
Frequent dialogue between pharmacists and chemists at these centers enhances our understanding of drug development and the pharmaceutical environment in different countries. It also serves to expand our expert knowledge on excipients, processes, and drug delivery technologies.
\n
Gattefossé has continuously developed close relationships with researchers from pharmacy faculties at universities around the world. These collaborations continue to be a source of inspiration, innovation, and learning and have led to many publications in peer review journals.
\n"},{"wysiwyg":"
Technical support and knowledge sharing for customers
\n
The objective of our Technical Centers of Excellence is to provide support for customer projects. They are not Contract Research Organizations (CROs). Projects include evaluation of the solubility of active ingredients in excipients; optimization of oral, topical, and rectal/vaginal formulations; formulation performance assessment by pharmacopoeia and in-house methods; process feasibility studies; and the provision of troubleshooting tips. Gattefossé is committed to providing training to customers around the world. This training takes several forms:
\n
\n
Lipid Schools (in-house or at customers’ premises)
Lipid-based drug delivery (LBDD) systems are increasingly used to overcome poor drug solubility and improve oral bioavailability. As a pioneer in the field of self-emulsifying and self-microemulsifying drug delivery systems (SEDDS and SMEDDS), Gattefossé has put much work into the development of formulation strategies and characterization methodology. Our customers benefit from our Formulation Guidelines, training, and one-to-one advice on LBDD development.
\n
Modified-release
\n
Lipid excipients enable the straightforward development of sustained-release matrices with high physiological resistance. Our case studies address a range of APIs and formulation through various processes (e.g., direct compression, wet/hot granulation, and hot melt extrusion). Certain APIs have been the focus of scale-up operations and human in vivo studies. Customers may have access to our Formulation Guidelines and practical tips for the development of robust SR formulations.
Gattefossé emulsifiers enable the development of simple topical formulations with the texture and sensorial quality of cosmetic products. Our prototype formulations are subject to in-house sensorial analysis through which we learn how to optimize texture and sensorial aspects by appropriate selection of excipients and formulation. Customers have access to our data bank of prototype formulations and technical support to develop superior products.
\n
Solubility enhancement
\n
The development of topical formulations allowing targeted transcutaneous drug penetration is a challenge. We have studied the solubilizing capacity of our excipients in conjunction with specific APIs and developed skin-penetrating formulations subject to industry-standard in vitro tests.
Decades of experience in suppository formulation and specialized analytical equipment enable us to develop robust suppositories with excellent drug delivery properties. Our formulation data bank, ability to match APIs with appropriate suppository or pessary bases, and expertise in scale-up and production mean we can help customers develop new products, or reformulate existing ones faster.
\n"},{"wysiwyg":"
Multidisciplinary research: Driving innovation and service
\n
An immense advantage is afforded by the proximity and close collaboration of formulators from our Pharmaceutical Application, Pharmaceutical R&D, Oleochemistry, and Cosmetic Application Laboratories. Their interactions and synergies drive product and process innovation, continuous improvement, and enhanced customer support services.
\n
R&D pharmaceuticals
\n
The main activities of the Pharmaceutical R&D Department (Saint Priest, France) are
\n
\n
raw material and excipient research and characterization;
\n
investigation of the structural-functional relationship of excipients and their behavior in the human body, including excipient behavior in biorelevant media (dispersion and digestion) and interactions with biological barriers.
Our oleochemists develop analytical methods to precisely evaluate the composition of lipid excipients, making it possible to isolate specific components for further functional studies in the R&D pharmaceutical laboratory. This work enables us to understand more about excipient Critical Material Attributes, which are essential to Quality by Design. Our oleochemists also design and synthesize new excipients with optimized formulation properties.
\n
Cosmetic Application laboratories
\n
Collaboration with cosmetic formulation experts is a source of new, shared knowledge and fosters cross-fertilization. These connections strongly inspire our Dermacare offerings through the application of sensorial analysis and mapping techniques to develop optimized prototype formulations with our range of emulsifiers.
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Emulium® Illustro est un émulsionnant eau-dans-huile hautement compatible avec les pigments et les filtres UV, mais également avec une large gamme d’ingrédients cosmétiques. Sans PEG et approuvé COSMOS, ce nouvel ingrédient répond parfaitement aux attentes des consommateurs en termes de naturalité et aux exigences des formulateurs grâce à sa performance et sa flexibilité.
\n","use_level":"3-5%","naturalite":"Approbation monde pour les applications cosmétiques \r\nInscrit sur l'IECIC (Inventory of Existing Cosmetic Ingredients in China) 2015 \r\nApprouvé COSMOS \r\nBrevet en cours","inci":"Polyglyceryl-6 Polyhydroxystearate (and) \r\nPolyglyceryl-6 Polyricinoleate (and) \r\nPolyglycerin-6","origin":"
Aujourd’hui, on observe un intérêt grandissant des consommateurs pour des produits cosmétiques naturels et sans silicones, notamment en soin solaire et en maquillage.
\n
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Gattefossé s’est appuyé sur sa solide expertise en chimie des lipides pour développer Emulium® Illustro. Six années de recherche et développement ont été nécessaires pour concevoir cet émulsionnant performant et flexible qui remplacera aisément les textures eau-dans-silicones.
Pour formuler avec Emulium® Illustro, choisir les bons émollients est essentiel pour prévenir les problèmes d’instabilité. Découvrez comment les sélectionner dans cette vidéo !
Conçu principalement pour les formules pigmentées, Emulium® Illustro aide à disperser les pigments et les filtres UV afin d’obtenir des formules homogènes et stables.
Conçu principalement pour les formules contenant des pigments
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100% d’origine naturelle
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Pas besoin de co-émulsionnant
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Compatible avec un process à froid
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Compatible avec une large gamme d’ingrédients cosmétiques
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Textures ultra fluides à épaisses
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Maquillage : fonds de teint, anti-cernes, BB et CC crèmes, enlumineurs, produits pour les yeux et les lèvres
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Solaire : crèmes solaires avec filtres organiques et inorganiques
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Soin de la peau
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Formules naturelles, certifiées bio et vegan
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A non-ionic pure surfactant for lipid-based formulation to solubilize and increase oral bioavailability of poorly soluble API. Forms micellar solution in aqueous media.
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Polyoxyl-32 stearate (type I) NF
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Macrogol-32 stearate (type I) EP
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33GX5WQC0M
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PEG-32 STEARATE
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Polyoxylethylene stearates
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2010 – 44th Journées galéniques de St Rémy de Provence: “Is there a role for essentials oils in current and future healthcare?”
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Robert Anton, Chair of the Foundation’s Aromatherapy Steering Committee
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This event, specifically dedicated to essential oils, and held between the 17th and 20th June 2010 included presentations and discussions on various aspects of essential oils, attended by international experts, university professors, and specialists. Following their interesting conclusions, the decision was taken to promote their uses in accordance with clearly defined restrictions.
2014 -“Huiles essentielles et innovations cliniques en milieu hospitalier” [Essential oils and clinical innovations] meeting
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This meeting, held in Lyon in November 2014, was attended by doctors, nurses, healthcare managers, trainers and university professors. It provided an opportunity to share experiences and good practices for the use of essential oils in hospital settings.
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“Our objectives are to make healthcare professionals feel less alone in their departments, overcome hesitations, fulfil desires and promote initiatives”.
2017 – Françoise-Couic Marinier’s conference in Saint-Priest, France
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Françoise Couic-Marinier, a Doctor of Pharmacy, aromatherapy trainer and member of the Foundation’s Aromatherapy Steering Committee, was invited to Lyon in September 2017 to present and explain to Gattefossé staff the different uses of essential oils in hospital settings.
Essential oils can be used in different ways as a complementary therapeutic approach in hospital settings. They help to treat different types of pain and illnesses.
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Aromatherapy can have a genuine impact on patient health but also on caregiver well-being. Françoise Couic-Marinier presents the expected benefits.
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Essential oils can be used in different ways in hospital settings such as diffusion, massage or cutaneous application. Françoise Couic-Marinier presents the various methods of application.
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\n
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Some APIs present poor organoleptic properties; therefore, taste or odor need to be masked. Others are sensitive to water, oxidation, or temperature and need to be protected to maintain stability. Certain lipid excipients are used in melt processes to effectively protect the API from degradation or mask taste and odor.
\n
\n
\n
Advantages of Gattefossé’s taste-masking and API protection agents:
\n
• thermoplastic behavior conducive to processes used (high shear coating, hot melt coating, granulation, extrusion, and capsule molding) • solvent-free process • chemically inert—highly compatible with other excipients in the formulation • plastic deformation for high resistance to compaction • lipid coating that does not impact bioavailability
lipid excipient with intermediate melting point (43 °C)
\n
ideal for capsule molding process
\n
\n
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This is the simplest process for the production of tablets. It consists of three main steps: powder blending, lubrication, and compression. Atomized lipid excipients are used as lubricants or modified-release agents in direct compression.
\n
\n
Advantages of lipid excipients in direct compression:
\n
\n
batch-to-batch composition uniformity, ensuring high quality and performance of final product (adequate for QbD development)
\n
chemical inertness, preventing incompatibilities with other excipients or with drug
\n
tablet hardness, resulting in robustness as product is not affected by compression
\n
\n
Range of functional excipients for direct compression:
\n
\n
Lubricants to decrease friction between particles and compression tools\n
We can provide technical guidelines on the use of Compritol® 888 ATO as lubricant for challenging pharmaceutical tablets that offer useful tips and numerous case studies.
Compritol® 888 ATO—a well-established sustained-release agent with precedence of use and numerous publicationsdemonstrating efficacy
\n
\n
\n
\n
We can provide technical guidelines that offer useful tips on SR formulation development and numerous case studies with model drug molecules, e.g., bupropion HCl, levodopa, metformin HCl, metoprolol succinate, niacin, and theophylline.
\n
\n
\n
\n
Sticking issue
\n
Sticking during tableting is a relatively common problem. It is often attributable to tooling and machine setup. However, the formulation, active ingredient, and excipients can play an important role. We conducted an in-house study to evaluate the cause of punch adhesion or “sticking,” which occasionally occurs during the compression of powder formulations containing Compritol® 888 ATO. Our study concludes that sticking is primarily due to a combination of factors, including formulation with a “sticky” API and use of ingredients with reduced interparticle bonding capacity.
\n
Contact Gattefossé for the full study report.
\n
\n
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Acne is the result of an excess of sebum and blemishes. While this skin problem affects almost all teenagers, it can also persist into adulthood: adult acne affects one in five women today. It may have a severe impact on self-esteem, not to mention potential after effects such as scarring and post-inflammatory disorders.
\n
A targeted solution is necessary that will both treat blemishes and ensure the skin remains shine-free.
Cytobiol™ Iris A² is a synergistic blend of three active ingredients: – Iris Rhizome Extract: cultivated in the Mediterranean region, iris rhizomes are rich in sugars and polyphenols, which give them moisturizing, soothing, astringent and anti-inflammatory properties. – Vitamin A: this active has seboregulating properties and acts as a skin regenerator. – Zinc Salt: this mineral element is essential for healthy skin. In Cytobiol Iris A2, it functions as an antibacterial seboregulator. Preservative free.
Designed to fight the causes of oily skin, Cytobiol™ Iris A² has been clinically shown to purify the skin, diminish shine, minimize pores, and reduce skin imperfections. Cytobiol™ Iris A² is an efficient active for a uniform, matte, poreless, and blemish-free complexion.
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Solvent and powerful solubilizer. Cosolvent in surfactant oral formulations—LFCS Type III (SMEDDS) and Type IV (micellar solutions). Vehicle in nasal and ophthalmic formulations. Safety of use and low irritancy inferred by numerous toxicological studies and precedence of use in approved pharmaceutical products.
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A nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs. Self-emulsifies in aqueous media forming a fine dispersion, i.e., microemulsion (SMEDDS).
\n","names_kv":[{"keys":"USP NF Name","value":"
Stearoyl polyoxyl-32 glycerides
\n"},{"keys":"EP Name","value":"
Stearoyl macrogol-32 glycerides
\n"},{"keys":"UNII Code (FDA)","value":"
G6EP177239
\n"},{"keys":"Preferred Substance Name (FDA)","value":"
PEG-32 HYDROGENATED PALM GLYCERIDES
\n"},{"keys":"Handbook of Pharmaceutical Excipients","value":"
Polyoxylglycerides
\n"},{"keys":"Chemical description","value":"
Consists of mono, di- and triglycerides and PEG-32 (MW 1500) mono- and diesters of palmitic (C16) and stearic (C18) acids
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into coarse emulsion—LFCS Type III (SMEDDS). Modulation of drug release. Lipid binder in melt processes. Safety of use is inferred by toxicological data and precedence of use in approved pharmaceutical products.
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Conditions Générales d’Utilisation du site Gattefosse.com :
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Objet
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Les présentes Conditions Générales d’Utilisation (« Conditions Générales d’Utilisation » ou « CGU ») s’appliquent à la navigation sur le site internet www.gattefosse.com (le « Site ») et à l’utilisation des fonctionnalités du Site.
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En accédant au Site, l’utilisateur (l’ « Utilisateur ») reconnaît avoir lu et accepté sans réserve l’ensemble des présentes Conditions Générales d’Utilisation et s’engage à les respecter.
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Les présentes Conditions Générales d’Utilisation sont susceptibles d’être révisées par Gattefossé à tout moment sans autre formalité que la mise en ligne d’une nouvelle version modifiée, cette dernière prévalant sur toute précédente version.
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Accès au Site
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Le Site est accessible gratuitement en tout lieu à tout Utilisateur disposant d’un accès à Internet.
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Tous les frais nécessaires pour accéder au Site (matériel informatique, logiciels, connexion Internet, etc.) sont à la charge de l’Utilisateur.
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En cas d’interventions de maintenance, d’évènement hors de contrôle de Gattefossé, de panne ou en cas de force majeure, l’accès au Site peut être interrompu ou suspendu sans préavis ni justification et sans que la responsabilité de Gattefossé ne puisse être recherchée.
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En outre, Gattefossé se réserve le droit d’interrompre ou de cesser définitivement la diffusion du Site, à tout moment, sans préavis ni justification et sans que sa responsabilité ne puisse être recherchée.
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Espace Réservé
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Tout Utilisateur qui souhaite avoir accès à l’espace réservé (l’ « Espace Réservé ») doit s’inscrire en remplissant le formulaire.
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Pour son inscription à l’Espace Réservé, l’Utilisateur s’engage à fournir des informations exactes concernant son état civil, ses coordonnées (adresse email), l’entreprise pour laquelle il travaille, le domaine d’activité de celle-ci et le poste qu’il y occupe, et à les maintenir à jour pendant toute la durée d’utilisation de l’Espace Réservé.
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Ces informations pourront être modifiées par l’Utilisateur à tout moment en envoyant une demande par email à contact@gattefosse.com.
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L’inscription est soumise à la validation de Gattefossé qui reste libre de refuser l’inscription d’un Utilisateur, sans justification et sans que sa responsabilité ne puisse être recherchée.
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L’accès à l’Espace Réservé est conditionné par la saisie de l’adresse email renseignée lors de l’inscription et du mot de passe défini par l’Utilisateur.
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Ces identifiants sont strictement personnels et ne doivent pas être transmis à des tiers. Dans le cas contraire, l’Utilisateur sera responsable de l’usage qui en sera fait.
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Sans préjudice de ses autres droits et recours, Gattefossé se réserve le droit de suspendre ou supprimer, sans préavis, le compte de tout Utilisateur qui ne respecterait pas les présentes Conditions Générales d’Utilisation.
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L’Utilisateur pourra solliciter la suppression de son compte en envoyant un email à : contact@gattefosse.com en précisant ses noms, prénoms, adresse email et le motif de sa demande. La suppression du compte sera effective dans un délai raisonnable.
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Toute suppression de compte, quel qu’en soit le motif, engendre la suppression définitive de toutes informations personnelles de l’Utilisateur.
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Propriété intellectuelle
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Les marques déposées ou non, logos et signes représentés sur le Site ainsi que tous ses contenus (textes, iconographies, photographies, illustrations, mises en page, etc.), y compris les contenus de l’Espace Réservé, sont protégés par le Code de la Propriété Intellectuelle et plus particulièrement par le droit d’auteur.
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Toute reproduction, représentation, publication, rediffusion ou copie en tout ou partie de ces éléments doit recevoir l’autorisation préalable expresse de Gattefossé et/ou des titulaires des droits sur ces éléments.
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Le non-respect de cette obligation est susceptible de constituer un acte de contrefaçon sanctionné pénalement au titre des articles L335-2 et suivants du Code de la Propriété Intellectuelle.
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L’accès au Site ne saurait être interprété comme conférant à l’Utilisateur une licence ou un droit quelconque de propriété intellectuelle sur le Site et/ou sur ses contenus autre que celui de consulter et naviguer sur le Site.
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Il est en outre interdit à tout Utilisateur d’utiliser un robot ou tout autre procédé automatique permettant d’accéder, d’aspirer ou d’extraire les données contenues ou présentées sur le Site.
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Sans préjudice de ce qui précède, tout Utilisateur dûment inscrit à l’Espace Réservé pourra télécharger les supports mis à disposition dans l’Espace Réservé. Ces supports ne pourront être utilisés qu’à des fins personnelles et d’information, à l’exclusion de tout usage commercial et/ou publicitaire. L’Utilisateur s’interdit en outre (i) de supprimer ou modifier les mentions relatives aux droits d’auteur et toute autre mention de propriété apposée ou contenue dans ces supports (ii) de modifier ou d’altérer ces supports et leurs contenus (iii) de publier et diffuser, de quelque manière que ce soit, à titre onéreux ou à titre gratuit, ces supports et leurs contenus. Plus généralement l’Utilisateur s’interdit de porter atteinte, directement, indirectement ou par l’intermédiaire de tiers, de quelque façon que ce soit, aux droits de Gattefossé et/ou aux droits de tiers sur ces supports.
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Données à caractère personnel
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Gattefossé peut être amenée à collecter et traiter des données à caractère personnel que les Utilisateurs lui fournissent au cours de leur navigation sur le Site.
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Gattefossé s’engage à collecter et traiter ces données dans le respect de la législation applicable et des dispositions de sa Politique de Protection des Données Personnelles.
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Cookies
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Lors de la navigation sur le Site, des cookies peuvent être déposés sur le terminal de l’Utilisateur (ordinateur, tablette, smartphone). Un cookie est un petit fichier informatique déposé sur le terminal de l’utilisateur par le biais de son navigateur Internet qui permet de conserver certaines données afin de faciliter la navigation sur un site Internet et de permettre certaines fonctionnalités.
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L’utilisation de ces cookies par Gattefossé est régie par les dispositions de sa Politique de Protection des Données Personnelles.
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Responsabilité
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Gattefossé ne fournit aucune garantie, qu’elle soit expresse ou tacite, concernant le Site et/ou tout ou partie de ses contenus.
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Gattefossé emploiera ses meilleurs efforts afin que les informations présentées sur le Site soient précises, à jour et fiables mais ne saurait en aucun cas être tenue responsable d’une quelconque erreur ou omission à cet égard.
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Les informations présentées sur le Site sont fournies à titre purement informatif.
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En conséquence, Gattefossé ne pourra être tenue responsable d’aucun dommage, direct ou indirect, de quelque nature que ce soit, qui découlerait de l’utilisation par l’Utilisateur des informations présentées sur le Site.
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Gattefossé décline toute responsabilité concernant les éventuels virus pouvant infecter le matériel informatique de l’Utilisateur en raison de l’accès au Site ou de son utilisation.
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Gattefossé ne pourra pas être tenue responsable des éventuelles difficultés d’accès au Site et/ou d’interruptions de connexion Internet. De même, la responsabilité de Gattefossé est exclue en cas de force majeure.
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D’une manière générale, Gattefossé décline toute responsabilité en cas de dommages directs ou indirects, quelles qu’en soient les causes, origines, nature ou conséquences, qui découleraient de l’accès et/ou de l’utilisation du Site et/ou de ses contenus, l’Utilisateur en assumant seul l’entière responsabilité et les risques en résultant.
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Liens vers d’autres sites Internet
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Le Site peut présenter des liens hypertextes orientant l’Utilisateur vers d’autres sites Internet. Gattefossé décline toute responsabilité concernant l’accès et l’utilisation de ces sites et/ou de leurs contenus, l’Utilisateur en assumant seul l’entière responsabilité et les risques en résultant.
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Droit applicable, juridictions compétentes
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Les présentes Conditions Générales d’Utilisation sont soumises à la loi française. En cas de contestation ou de litige, les tribunaux de Lyon seront seuls compétents, y compris en cas de référé, d’appel en garantie ou de pluralité de défendeurs
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Conditions Générales de Vente :
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Veuillez trouver ci-dessous les conditions générales de vente (” CGV “) applicables à toutes les ventes de produits et/ou de services par la filiale correspondante du groupe Gattefossé :
Pour connaître les conditions générales applicables aux ventes des autres filiales de Gattefossé, veuillez contacter votre représentant commercial local.
\n","box_links":[],"useful_links":[],"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages/538"}],"collection":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/comments?post=538"}],"version-history":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/pages/538/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/media?parent=538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/categories?post=538"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/fr/wp-json/wp/v2/tags?post=538"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"privacy-policy":{"id":20144,"date":"2020-07-21T11:45:17","date_gmt":"2020-07-21T09:45:17","guid":{"rendered":"https://www.gattefosse.com/?page_id=20144"},"modified":"2021-02-24T17:21:03","modified_gmt":"2021-02-24T15:21:03","slug":"privacy-policy","status":"publish","type":"page","link":"https://www.gattefosse.com/corporate-content/privacy-policy/","title":{"rendered":"Privacy policy"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":""},"categories":[48],"tags":[],"acf":{"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"component":"PageGenericContentCorporate","title":"PERSONAL DATA PROTECTION POLICY","content":"
Version in force on 04/02/2021
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Purpose
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Personal data is information that may allow, directly or indirectly, the identification of a natural person. This includes, for example, surnames, first names, email addresses, telephone numbers, user names, IP addresses, cookies, etc.
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This Personal Data Protection Policy applies to personal data collected by Gattefossé directly from users (the “Users”) of the website www.gattefosse.com (the “Website”).
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In its capacity as data controller, Gattefossé undertakes to collect, process and store the personal data of Users in complete confidentiality and in accordance with the provisions of this Policy.
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By accessing the Website, the User acknowledges having read and accepted, without reservation, the terms of this Personal Data Protection Policy.
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Purposes of processing
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Gattefossé collects the personal data that Users agree to provide. Data is collected and processed for the following purposes:
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Contact form\n
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Management, processing and response to Users’ enquiries and requests for information and/or samples;
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Management and processing of requests for information, access, rectification, deletion or portability of personal data or requests to oppose or restrict data processing.
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Cookies\n
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Facilitation of browsing on the Website;
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Sharing of videos, animated and interactive content;
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Statistics (analysis of traffic on the Website for example);
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Analyses to develop and improve browsing on the Website and/or the content of the Website.
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Registration form for the Members’ Section of the Website\n
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Validation and management of access to the Members’ Section of the Website;
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Commercial prospecting;
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Management and processing of requests for information, access, rectification, deletion or portability of personal data or requests to oppose or restrict data processing.
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Request form for samples in the Website’s Members’ Section\n
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Management, processing and response to Users’ enquiries and requests for information and/or samples.
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The User is hereby informed of the purpose of processing prior to any collection of personal data and has the opportunity to oppose it.
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Duration of storage
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In accordance with legal requirements, the personal data of Users collected on the Website will be stored by Gattefossé only for the time required to fulfil the intended purpose, namely:
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Contact form: time required to process the enquiry or request plus two (2) years
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Cookies: two (2) years
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Registration form for the Website’s Members’ Section: period of validity of access to the section plus two (2) years
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Request form for samples in the Website’s Members’ Section: time required to process the request plus (2) years
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The personal data collected will be deleted:
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At the end of the term stipulated above; or
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At the User’s request, in accordance with the applicable regulations and the procedures provided for in Article 7 below (subject to any legal retention obligation).
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Transmission
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Should it prove necessary, personal data collected on the Website may be communicated to other Gattefossé Group entities worldwide. The latter must comply with the processing purposes defined for this data.
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This data may not be sent to third parties for commercial and/or promotional purposes without the User’s prior consent.
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On the other hand, this data may be sent to certain service providers/technical subcontractors of Gattefossé (hosting company or audience analysis service in particular) bound to the confidentiality and security of this data and exclusively for the purposes described in Article 2 above.
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In the event that the data is transferred to a country that is not a member of the European Union and is not subject to an Adequacy Decision, Gattefossé will take all necessary measures to ensure that the data is protected with an appropriate level of confidentiality and security.
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Gattefossé may be required to send the data to the competent administrative or judicial authorities, at their request.
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Confidentiality and security
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Gattefossé undertakes to set up all necessary technical and organisational measures to preserve the confidentiality and security of the personal data collected on the Website.
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However, Gattefossé cannot be held liable for a security failure attributable to the User.
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Cookies
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When browsing the Website, cookies may be placed on the User’s device (computer, tablet, smartphone). A cookie is a small computer file deposited on the User’s device through their internet browser that allows certain data to be stored in order to facilitate browsing on a website and enable certain functionalities.
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The User is informed of the use of cookies by a banner that appears when connecting to the Website. The User may choose to authorise or prohibit all or some of the cookies by clicking on the “Customise” button on the banner.
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The disabling of certain cookies may alter the operation of the Website. The User is informed of this when personalising cookies. In the event that the User decides to prohibit a cookie necessary for the optimal operation of the Website, Gattefossé cannot under any circumstances be held liable for the consequences relating to the altered or impaired running of the Website.
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Cookies can be deposited by Gattefossé partners (such as Google Analytics for example). These partners may also use the information contained in cookies.
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The User is entitled to withdraw their consent and/or their choice to personalise cookies at any time.
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Information on the User’s consent and choice of personalising cookies will be retained by Gattefossé for thirteen (13) months.
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User Rights
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In accordance with the provisions of Law no. 7817 of 6 January 1978 on Technology, Files and Civil Liberties (known as “Loi Informatique & Libertés”) and European Regulation 2016/679 of 27 April 2016 (General Data Protection Regulation), the User has the following rights with regard to their personal data:
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Right to information;
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Rights of access and rectification;
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Right of deletion;
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Right to oppose processing for legitimate reasons;
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Right to oppose, without reason, the processing of data for marketing purposes;
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Right to personal data portability;
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Right to restrict processing.
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These rights may be exercised at any time by the User by sending an email to: dataprotection@gattefosse.com, provided that proof of identity is attached.
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In the event of an unsatisfactory response from Gattefossé in exercising the rights mentioned below, the User may lodge a complaint with the French National Commission for Data Protection and Liberties (“CNIL”).
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Amendments
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This Personal Data Protection Policy may be updated at any time by Gattefossé without any formality other than the online publication of a new amended version, the latter prevailing over any previous version.
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\n"},{"keys":"EP Name","value":"
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\n"},{"keys":"UNII Code (FDA)","value":"
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Impact of Granulation Solvent on Release Performance of Dual Matrix Extended-Release Tablets of Highly Water-Soluble Drugs Formulated using Compritol® 888 ATO and Methocel® as Release Retarding Agents
Impact of Granulation Solvent on Release Performance of Dual Matrix Extended Release Tablets of Highly Water Soluble Drugs Formulated using Compritol® 888 ATO and Methocel® as Release Retarding Agents
The purpose of this study is to evaluate the impact of different granulation solvents on the performance of dual extended- release matrix tablets, formulated using a combination of Compritol® 888 ATO and Methocel® K100M, with two model APIs:
\n
\n
highly water-soluble high dose (1000 mg) Metformin Hydrochloride
Selecting efficient pharmaceutical binder for developing robust extended-release matrices of Compritol® 888 ATO prepared using wet granulation technique : Part 1 Studying impact on granule & tablet properties
\n
K. Deshmukh, A. Shrivastava, S. Banerjee, R. Tiwari, S. Bambarkar, N. Farah Gattefosse India Pvt. Ltd., Mumbai, INDIA, Gattefosse SAS, Lyon, FRANCE
Selecting efficient pharmaceutical binder for developing robust extended-release matrices of Compritol® 888 ATO prepared using wet granulation technique: Part 2 Studying impact on dissolution profiles of ER tablets of different API’s
\n
K. Deshmukh1, A. Shrivastava1, S. Banerjee1, R. Tiwari1, S. Bambarkar1, N. Farah2 1Gattefosse India Pvt. Ltd., Mumbai, INDIA, 2Gattefosse SAS, Lyon, FRANCE
Influence of Formulation Factors and Compression Force on Release Profile of Sustained Release Metoprolol Tablets using Compritol® 888 ATO as Lipid Excipient
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Shilpa N. PATERE, Chhanda J. KAPADIA and Mangal S. NAGARSENKER Indian J Pharm Sci 2015;77(5): 620-625 Release profile of metoprolol from sustained release tablets using Compritol 888 ATO as SR lipid matrix agent showed high reliability. Different sources of active ingredient and batches of Compritol were evaluated at different compression forces and in dissolution media containing or not ethanol. The formulation appeared to be very robust and is not affected by these variables. Therefore Compritol offers great potential in the formulation of reliable SR tablets.
Smart strategies for sustained release tablets: Compritol® 888 ATO
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White paper – May 2014 This white paper gives an overview of how Compritol® 888 ATO provides clinically relevant sustained drug release profiles along with biopharmaceutical, formulation and manufacturing advantages.
Solid lipid excipients – matrix agents for sustained drug delivery.
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Yvonne Rosiaux, Vincent Jannin, Sophie Hughes, Delphine Marchaud Journal of Controlled Release Volume 188, 28 August 2014, Pages 18–30
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This review article focuses on the utility of lipid excipients in solid sustained drug delivery systems with emphasis on the efficiency and robustness of these systems with respect to: (i) the choice of the manufacturing process and impact on drug release, (ii) the fundamental drug release mechanisms, (iii) resistance of the drug formulation under physiological conditions and (iv) long-term stability. Understanding the functionality of these versatile excipients in formulation is elementary for the development of highly robust lipid-based sustained release medicines
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Improvement of topical dosage form texture and sensorial properties is an increasingly common formulation objective:
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Improved texture and sensorial properties positively impact patient experience and adherence to treatment.
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A growing number of topical medicines switch over to OTC, where brand differentiation and patient choice comes into play.
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Innovation can be achieved by reformulating the dosage form with optimized texture and sensorial features.
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Sensorial mapping evaluates product’ aspects during application and absorption. We have developed a database of prototype formulations with different textures and sensorial profiles. This helps our customers select formulations with excellent texture and sensorial properties. Dermacare is a collection of simple and effective prototypes of creams, emulgels, and lotions with optimized texture and sensorial properties. Our database also includes formulations for foams, sprays, microemulsions, and gels. Contact Gattefossé for our Dermacare guidelines.
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We know that ingredients or even formulation type—for example, cream versus emulgel—can directly affect sensorial properties. Sensorial panel experts at Gattefossé Application Laboratories can study these factors.
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publication ","main_title":"The Camera Never Lies","main_link":"https://www.cosmeticsandtoiletries.com/research/methodsprocesses/The-Camera-Never-Lies-Visualizing-Sun-Protection-Loss-and-Ways-to-Fortify-Films-507828621.html","button_label":"ALL PUBLICATIONS","button_link":"https://www.gattefosse.com/personal-care-trends/publication-finder/"}]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/929"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=929"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/929/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=929"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=929"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=929"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"a-history-of-plants":{"id":6267,"date":"2017-09-25T16:47:44","date_gmt":"2017-09-25T14:47:44","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=6267"},"modified":"2022-06-10T10:15:10","modified_gmt":"2022-06-10T08:15:10","slug":"a-history-of-plants","status":"publish","type":"page","link":"https://www.gattefosse.com/our-business/personal-care-trend/a-history-of-plants/","title":{"rendered":"A history of plants"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"A history of plants: plant-based actives at Gattefossé","_yoast_wpseo_metadesc":"Botany is a constant source of inspiration. Developing new plant-based actives is one of the main missions of Gattefossé’s scientific team."},"categories":[56],"tags":[],"acf":{"component":"PageGenericContentCos","title":"A history of plants","content":"
Botany is a constant source of inspiration. The diversity of plants around the world, their properties, their unique composition and their benefits to health and beauty make them a fascinating fieldwork for scientists.
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Developing new plant-based actives is one of the main missions of Gattefossé’s scientific team.
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A long history
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It all starts with René Maurice Gattefossé, back in the 1910s. He spent many years working on lavender fields, in Provence (France), helping the farmers to improve cultivation and distillation methods and creating the first lavender growers’ cooperative.
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Later, he purchased a farm in Saint-Rémy-de-Provence, thus creating an aromatic plant production and distillation center, providing his company with raw materials.
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A solid knowledge & team work
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Gattefossé scientists have a strong knowledge in botany but also in phytochemistry, physiology and ecology. This allows them to select the best raw materials.
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The first step consists in identifying the plants of interest for a specific cosmetic application. This complex process – where chemistry, taxonomy and knowledge of customers’ requirements intersect – leads to the discovery of new botanical materials.
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The activity of the plant extracts that caught our attention is then evaluated in preliminary research to validate their action on specific biological targets and to ideally identifythe exact molecules responsible for this activity.
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Once the plant identified and validated, our team select the best sourcing, based on geographical origin, cultivation and harvesting methods, respect of the environment, shipment conditions, etc.
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From planting stage to harvest and shipment, all steps are controlled to ensure a responsible and sustainable supply chain, strictly following all regulations concerning access to biodiversity, fair trade and environment. Our set of specifications is clearly defined and applies for all our partners.
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Experts in extraction
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Green chemistry is at the heart of our processes. Depending on the plant we are working on and the results that are expected, different methods and solvents can be used to extract the active fraction in the plants:
Each process is optimized to guarantee a constant content of active molecules in each batch produced.
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Gattefossé has also developed a wide range of separation, purification, soaking and concentration techniques that uses ultrafiltration, distillation or chromatography.
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All these techniques, combined with Gattefossé’s knowledge and expertise, allow us to provide the market with high-quality ingredients.
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\n","box_links":[],"useful_links":[{"text_link":"Gattefossé's history","link":false,"external_link":"https://www.gattefosse.com/fr/corporate-expertise/gattefosse-history/"},{"text_link":"Our commitments","link":"https://www.gattefosse.com/our-business/corporate-expertise/our-commitments/","external_link":""},{"text_link":"Sustainable cosmetics & RSPO","link":"https://www.gattefosse.com/our-business/personal-care-special-content/sustainable-cosmetics-rspo/","external_link":""},{"text_link":"The NaDES technology","link":"https://www.gattefosse.com/our-business/personal-care-trend/the-nades-technology/","external_link":""}],"":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"main_img_article":{"id":13952,"alt":"","title":"history-of-plants","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/history-of-plants.jpg","width":1536,"height":510,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/history-of-plants-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/history-of-plants-300x100.jpg","medium-width":300,"medium-height":100,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/history-of-plants-768x255.jpg","medium_large-width":474,"medium_large-height":157,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/history-of-plants-1024x340.jpg","large-width":474,"large-height":157,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/history-of-plants-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/01/history-of-plants-1038x510.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":510}},"description":"","view_all":"personal-care/trends-education-inspiration/","filter_categories":["expertise"]},"_links":{"self":[{"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/pages/6267"}],"collection":[{"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/comments?post=6267"}],"version-history":[{"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/pages/6267/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/media?parent=6267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/categories?post=6267"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/tags?post=6267"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"gattefosse-publications":{"id":3753,"date":"2017-04-28T12:27:50","date_gmt":"2017-04-28T10:27:50","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=3753"},"modified":"2023-06-13T08:22:14","modified_gmt":"2023-06-13T06:22:14","slug":"gattefosse-publications","status":"publish","type":"page","link":"https://www.gattefosse.com/pharmaceuticals-documentation/gattefosse-publications/","title":{"rendered":"Gattefossé publications"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"An exhaustive list of all the scientific publications from Gattefossé experts","_yoast_wpseo_metadesc":"Find out the scientific articles and posters written by our pharmaceutical scientists about lipid-based excipients and formulation technologies."},"categories":[63],"tags":[],"acf":{"component":"Brochures","title":"Gattefossé publications","introduction":"Find below the list of all publications (articles and posters) of Gattefossé scientists.Posters are available to download after log-in.","":false,"content":[{"wysiwyg":"
Ethanol-resistant ethylcellulose/guar gum coatings – importance of formulation parameters
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In vitro digestion of the self-emulsifying lipid excipient Labrasol® by gastro-intestinal lipases and influence of its colloidal structure on lipolysis rate
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Ethanol-resistant polymeric film coatings for controlled drug delivery
Compartmentalization of the human stratum corneum by persistent tight junction-like structures
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2010
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Diluent effects on drug release from sustained release Compritol® 888 ATO tablets
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Gastro-intestinal lipolysis of lipid-based excipients intended for oral drug delivery of poorly water soluble drugs
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Specific assay of carboxyl ester hydrolase using PEG esters as substrate
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An investigation into the mechnism of dissolution rate enhancement of poorly water soluble drugs from spray chilled Gelucire® 50/13 microspheres
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2009
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Lauroyl polyoxylglycerides, functionalized coconut oil, enhancing the bioavailability of poorly soluble active substances
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Vaginal cream formulation for the prevention of HIV infection for women in developing countries
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In vitro gastrointestinal lipolysis of four formulations of piroxicam and cinnarizine with the self-emulsifying excipients Labrasol® and Gelucire® 44/14
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Influence of drug polarity upon the solid-state structure and release properties of self-emulsifying drug delivery systems in relation with water affinity
Bibliography on Gattefossé’s products. 2004-2005 review.
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Systèmes auto-emulsionnables et émulsions sèches [Self emulsifying drug delivery systems]
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2004
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Structural and thermal characterization of lipidic excipients and carriers by X-ray diffraction coupled to differential microcalorimetry
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Structural and thermal characterization of mono and diacyl polyoxyethylene glycol by infrared spectroscopy and X-ray diffraction coupled to differential calorimetry
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2003
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Enhanced bioavailability of simvastatin in a self-emulsifying drug delivery system (SMEDDS)