Let’s now discover the Glittering Gummies (2745-3.04), a surprising travel-friendly format for a highlighter, made possible by Emulium® Kappa MB! Compact and easy to carry, this solid O/W emulsion is perfect for touch-ups on the go.
\n
It offers an ultra-bouncy effect and melting sensation thanks to Lipocire® A SG and creates a fresh and watery effect upon application. \n (97.4% natural origin)
\n\n
\n
Craving uniqueness? The Holo Eye Liner (2758-1.11) has been designed to reveal the eccentricity living in you while reamining smudge-free and waterproof. Creamy and quick-drying, it melts seamlessly thanks to Lipocire® A SG to leave an intense purple, holographic line with long-wear properties! Emulium® Dolcea MB shows unfailing efficiency and robustness with this formula rich in pigments. \n (92% natural origin)
\n\n
\n
Playground
\n
\n
What if everyday life became a playground (again)? Gattefossé encourages more playful cosmetic application with our Cottage Cheese cream (2748-1.11) and its Squid Ink Topping (2748-2.04)! With Emulium® Dolcea MB, Acticire® MB, and EnergiNius® this creamy, yogurt-like texture delivers moisturizing and energizing benefits, perfect for daily application. Recommended once a week or once a month, mix it with 2 drops of the Squid Ink Topping, enriched with Original Extract® Ginger, to create your own detox mask! \n (99.5% natural origin)
\n\n
\n
\n
Experience the unexpected
\n
\n
It’s time to discover new territories! Between the real and imaginary, appearances can be misleading… \n Like the Chayote-Kiwi Sorbet (2694-3.03), is it a beauty sorbet or a granita? With its light green color, you first see a food-like texture that you would love to eat. Upon initial application, you’ll feel a fresh, creamy yet powdery sensation, that leaves a dry, soft, non-tacky after-feel due to Emulium® Mellifera MB. This cushion cream brings a refreshing and intense moisturization, acts as a blur, and protects the skin from photoaging with Solastemis™. The skin appears radiant, even, and healthy. \n (99.4% natural origin)
\n\n
\n
Alien Slime (2614-3.01) is another optical illusion! is it slime, or is it a cosmetic? Try it and you’ll be surprised by its comfortable, stringy, but non-sticky after-feel thanks to Emulium® Dolcea MB & Acticire® MB.
\n
Adapted for sensitive skin, it has a long playtime which is perfect for a soothing massage! It can also be used as a leave-on so that you can appreciate its nourishing properties. \n (98.2% natural origin)
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Caprylocaproyl Polyoxyl-8 glycerides
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A nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs. Self-emulsifies in aqueous media forming a fine dispersion, i.e., microemulsion (SMEDDS).
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Lauroyl Polyoxyl-32 glycerides
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Lauroyl Macrogol-32 glycerides
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H5ZC52369M
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LAUROYL PEG-32 GLYCERIDES
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Polyoxylglycerides
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Consists of a small fraction of mono, di- and triglycerides and mainly PEG-32 (MW 1500) mono- and diesters of lauric acid (C12)
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into microemulsion—LFCS Type III (SMEDDS). Wetting agent. Lipid binder in melt processes. Safety of use is inferred by extensive toxicological evaluations and precedence of use in approved pharmaceutical products.
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Oxidative Stability in Lipid Formulations: a Review of the Mechanisms, Drivers, and Inhibitors of Oxidation
\n
Jasmine Musakhanian, Jean-David Rodier and Masumi Dave
\n
AAPS PharmSciTech – Vol. 23 – May 2022, Article number 151
Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
\n
Ben J. Boyd, Christel A.S. Bergström, Zahari Vinarov, Martin Kuentz, Joachim Brouwers, Patrick Augustijns, Martin Brandl, Andreas Bernkop-Schnürch, Neha Shrestha, Véronique Préat, Anette Müllertz, Annette Bauer-Brandl, Vincent Jannin
\n
European Journal of Pharmaceutical Sciences, Volume 137, 2019, 104967, \n ISSN 0928-0987, https://doi.org/10.1016/j.ejps.2019.104967.
\n
In this excellent review article issued from the UNGAP program (European Network on Understanding Gastro-intestinal Absorption-related Process) you will find relevant and up-to-date information on:
\n
\n
Poorly water soluble drugs and the link between physico-chemical properties and solubility, lipophilicity and permeability
\n
Technologies to increase solubility and dissolution rate: salt formation, amorphous solid dispersions, lipid-based formulations
\n
How to avoid precipitation and create a concentration gradient to improve absorption
\n
Methods for modelling the performance such as Molecular Dynamics Simulations
\n
In vitro methods for solubility and dissolution assessments
\n
Methods to explore the absorption in the GI tract: GI concentration-time profile, in vitro digestion, in vitro models coupling dissolution and permeation, mucus diffusion
\n
Impact of molecularly dissolved drug versus apparently dissolved drug (ie in colloidal structure)
1 Initial identification and characterization of the active ingredient \n 1.1 Physico-chemical characteristics \n 1.2 Impact of physicochemical characteristics on absorption \n 1.3 Passive diffusion prediction tools \n 1.4 In silico prediction \n 2 Biopharmaceutical classifications
\n
III Formulation strategies
\n
1 prerequisites \n 2 techniques for increasing the dissolution rate \n 3 Solubility enhancement technologies \n 4 Improving the permeability, oral route
\n
IV Control, assessment, prediction of the bioavailability
\n
1 Physicochemical control methods for the manufacturing intermediates and finished products \n 2 Assessing an dpredicting the bioavailability of the formulations
\n
V Alternative strategy: changing the route of administration
Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs
\n
Kapilkumar Vithani, Vincent Jannin, Colin W. Pouton, Ben J. Boyd
\n
In this review article, the authors explain the importance of the colloidal structures formed during dispersion and digestion of self emulsifying lipid-based formulations on drug solubilization and absorption.
\n
A review of the techniques used to characterize the colloidal structures is also carried out.
LIPID-BASED DELIVERY – Are Lipid-Based Drug Delivery Systems in Your Formulation Toolbox?
\n
Dr. Jason LePree Drug Development & Delivery, Issue: October 2017, Posted Date: 9/29/2017 This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome impediments to good bioavailability of therapeutic actives, including poor water solubility, low permeability, and degradation by stomach acid or enzymes in vivo.
Reaching milestones in lipid-based formulations: from effective prediction to successful development
\n
September 2015 This white paper describes the important milestones achieved in lipid based formulation (LBF) development for oral drug delivery. Collaborative research between academic and industrial partners has increased understanding of the functional properties of lipid excipients and the role they play in solubilizing poorly water soluble compounds. It has also led to the development of in vitro – in vivo predictive analytical tools. The key scientific articles describing these milestones are collected in this one White Paper, providing a single source of practical information for those interested in lipid formulation development.
This acticle describes the work undertaken in Gattefossé R&D labs (St Priest) to develop lipid formulations for low to medium lipophilicity API: piroxicam, nifedipine and curcurmin and evaluate the effect of in-vitro digestion on the solubilizing capacity of the formulations.
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We are experts in two complementary fields: lipid chemistry and plant extraction. This know-how enables us to meet the latest market trends in both natural performing actives and functional excipients, recognized for their sensorial benefits.
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\n We have been facing some trying times these past few years – a global pandemic, war, political divide, and climate change. It is no wonder many of us feel so stressed out, on top of our daily worries around work, school, or personal relationships. We know stress isn’t healthy for the mind, body, and soul. But, it is particularly damaging to the skin because “in times of stress, your stress hormones rise and trigger your oil glands to produce more oil, which then triggers acne flares.”*
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\n According to SPATE, the acne condition ranks #2 within the face concerns category of skincare, with the top subcategory of stress acne showing the highest year-over-year growth. We may not be able to resolve such global issues at Gattefossé, but we can surely provide you with self-care rituals to help you keep calm and Gatt’ your clear skin on!
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\n
FIGHT ACNE WITH GATTEFOSSÉ\n
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In overwhelming times, there truly is a need for cocooning and rejuvenating moments, which is why Gattefossé has developed a beauty routine comprised of 6 sensational creations that reinforce the pleasures of self-care while facing daily uncertainties. This light and fresh skincare kit guarantees an instant healthy glow and gives you a boost from morning to night!
This vibrant yellow, lemon-curd-looking texture is actually a fruit acid face mask! Stable at low pH, Emulium® Dolcea MB creates its gourmand and thick texture while Glypure 70 and Lemon Secrets™ give a renewed and luminous complexion. Simply apply on dry skin, leave on for 10 min, and then rinse.
No more shiny skin with this soft, formidable cream that mattifies the skin without drying it out. This creamy texture penetrates quickly and leaves a comfortable and matte film. Cytobiol™ Iris A² helps to fight against shine and reduce imperfections while Plurol® Stearique MB provides a dry, powdery after-feel.
Other body areas such as the décolleté, back, and shoulders can also suffer from imperfections. This ultra-fluid bi-gel, made possible with Emulfree® CBG MB, has been specifically designed to purify these areas without leaving a sticky or greasy film, so it’s easy to get dressed after applying.
Pimples are a thing of the past thanks to this natural transparent gel! Cytobiol™ Iris A² and Original Extract™ Lemon Bio help purify the skin and minimize breakouts. Plus, its texture is well-adapted for a pump or roll-on applicator for an ultra-targeted application.
This fluid texture is ideal for fighting imperfections! It spreads easily, penetrates quickly, and leaves a very soft, thin protective film, as acne-prone skin also needs protection. Emulium® Dolcea MB, which has demonstrated its moisturizing properties, and high quantities of propanediol, guarantee hydration. Plus, the skin is purified and clearer thanks to Cytobiol™ Iris A² and Original Extract™ Lemon Bio.
Wake up every morning with perfect skin, thanks to this multi-functional night cream! Formulated with Emulium® Mellifera MB, this texture penetrates quickly and leaves a fine, comforting protective film on the skin. Cytobiol™ Iris A² and Gatuline® Renew form an active combo that leaves the skin clear, matte, smoothed, and hydrated.
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Click here for more information or samples on the featured ingredients and formulas.
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\n
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Expression lines (i.e., fine lines) are the result of thousands of daily involuntary microcontractions of the facial muscles. They become more visible and deeper as we age and are a real concern for people who want to maintain a youthful appearance. Gatuline® Expression effectively prevents the appearance of expression lines and visibly smooths the skin surface. This fast-acting ingredient redefines both the eye and lip contours in record time.
\n","use_level":"2-5%","naturalite":"ECOCERT/COSMOS approved","inci":"Propanediol (and) Water (and) \r\n Acmella Oleracea Extract","origin":"
Natural, safe, preservative-free extract of a non-GMO plant grown in a protected environment. Acmella oleracea is a plant with small yellow flowers commonly used as a spice and anesthetic agent in Madagascar, from which it is sourced. In fact, its unique numbing effect led to its popularity in cocktails and the nickname “buzz buttons.” This anesthetic effect is also what drew the attention of Gattefossé researchers. Other grade available: Gatuline® Expression (INCI : Alcohol (and) Water (and) Acmella Oleracea Extract)
In vitro and in vivo tests prove Gatuline® Expression AF
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exerts a powerful, reversible myorelaxant effect; visibly smooths crow’s-feet after just one day of treatment;
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clearly reduces vertical wrinkles (i.e., bar code wrinkles and bitterness folds);
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redefines lip contour, making it sharper, finer, and more intense;
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continues to act on wrinkles over the long term.
\n
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Exerts myorelaxant effect
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Yields instantly visible results
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Provides natural alternative to injections
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Erases expression lines
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Smooths and redesigns the lip contour
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Recurves Cupid’s bow
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Capsule filling and molding are common technologies suitable for powder, liquid, and semisolid formulations. Atomized lipid excipients are used as lubricants, glidants, and flow aids for capsule filling with powders. Semisolid and liquid lipid excipients are mainly used as solubility enhancers in hard and soft capsules.
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Advantages of lipid excipients for capsule filling and molding:
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\n
high compatibility with capsule shell due to low impurity levels
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liquid and semisolid vehicles suitable for highly potent drugs
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high drug loading
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low melt viscosity and rapid solidification after molding
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chemical inertness, preventing incompatibilities with other excipients or with drug
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Range of functional excipients for capsule filling/molding:
Gelucire® 43/01—matrix-forming agent for protection of actives sensitive to oxidation, humidity, or light
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Oily vehicle / suspending agent\n
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Geloil® SC—vehicle for suspensions in soft gelatin capsules
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Optimum process temperature
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Gattefossé can help you determine the optimum process temperature and cooling rate for capsule filling and molding.
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\n
Contact Gattefossé to get thermorheogram.
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Pour formuler avec Emulium® Illustro, choisir les bons émollients est essentiel pour prévenir les problèmes d’instabilité. Découvrez comment les sélectionner dans cette vidéo !
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\n
Oral bioavailability of drugs is often limited by poor solubility and permeability. To overcome these hurdles, numerous strategies have been developed, among which lipid-based formulations (LBF). By combining unique in vivo benefits and fast development, LBF constitute a viable strategy to formulate a wide range of APIs. \n This webinar series will give junior formulators key information to understand how LBF address oral bioavailability issues, know the functionalities of Gattefossé excipients and the methodology to develop optimized lipid-based formulations.
\n
\n
\n"},{"wysiwyg":"
\n\n
\n
\n
Part I: Lipid-based formulations to address oral bioavailability issues
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To enable straightforward formulation of stable emulsion systems, Gattefossé offers a range of all-in-one emulsifiers. Due to their specific composition combining lipophilic and hydrophilic surfactants with a texture agent, they provide stable emulsions whatever the type and concentration of oil.
\n
\n
Advantages of lipid excipients:
\n
\n
self-emulsifying bases for all phases (glycerin, PEG, alcohol, propylene glycol, mineral oil, MCT)
\n
excellent compatibility with APIs (including salt forms), preservatives, and gelling agents
\n
yield creams with high heat stability over a wide pH range
\n
versatile—for formulation of sprays, lotions, creams, and balms with improved texture and sensorial properties
Gattefossé can provide prototype formulations that highlight win-win combinations of emulsifiers:
\n
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Tefose® 63 with Labrafil® M 1944 CS to improve stability
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Plurol® Diisostearique with Plurol® Oleique CC 497 to improve stability
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Gelot™ 64 with Emulcire™ 61 to improve sensorial properties
\n
Tefose® 1500 with Labrafil® M 2130 CS to improve stability
\n
\n
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A mesure que la peau vieillit, le derme subit différentes modifications affectant sa structure et entrainant une perte de fermeté et de tonicité. Les contours du visage et du corps sont modifiés, moins nets, les zones du décolleté et du cou apparaissent comme froissés.
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Gatuline® In-Tense MB est un actif d’origine naturelle agissant en profondeur dans la matrice extra-cellulaire. Il stimule l’activité des fibroblastes, apportant ainsi un soutien aux fibres de collagène. La fermeté de la peau est ainsi restaurée, elle paraît plus lisse et plus jeune.
\n
Une solution de choix pour des revendications fermeté corps et visage
Gatuline® In-Tense MB est un extrait huileux et concentré de fleurs d’Acmella Oleracea, communément appelé Cresson de Para, une plante utilisée en cuisine comme condiment et en médecine traditionnelle comme anti-douleur notamment.
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Riche en alkylamides, l’Acmella Oleracea est une plante de choix pour des bénéfices anti-âge.
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Lors de la récolte, seules les fleurs sont cueillies. La plante peut ainsi être valorisée dans d’autres usages, culinaires notamment.
Stimule les fonctions biomécaniques des fibroblastes
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Réduit l’apparence des rides au niveau du cou et du visage
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Lisse la zone du décolleté
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Améliore la fermeté et la tonicité de la peau
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Soins visage: anti-âge, anti-rides, soins dédiés aux contours du visage
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Soins corps: raffermissant, remodelant
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Maquillage: fond de teint fermeté, rouge à lèvre repulpant
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The 3rd Drug Development Networking Summit will take place in Parsippany, USA on March 8th 2018
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9:15 am – 9:45 am: conference from Jason LePree, PhD, Manager, Technical Center of Excellence, Gattefosse USA: Oral Delivery of Peptides: Overcoming Challenges
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Abstract: Oral administration of peptides is challenged by a number of physiological barriers, including pre-systemic degradation by proteases, deactivation by reduced glutathione, and poor intestinal membrane permeability. Lipid formulations, notably self-emulsifying drug delivery systems (SEDDS) can successfully overcome these challenges. In an interesting series of recently published works, model peptides leuprorelin, insulin, and desmopressin were formulated in SEDDS following hydrophobic ion-pairing of the peptides. The newly designed formulations facilitated payloads of >10% for peptide drugs, provided 100% protection against proteases, reduced glutathione, and improved their intestinal permeability. This session shares the intricacies and the promising results of the aforementioned work.
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Gattefossé can help you determine the lipid excipients you are seeking for and give you useful tips to process them.
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Today’s cosmetic products require flexibility and innovation, as well as simplicity. Consumers today are placing a higher emphasis on health and wellness, marked by a strong return to traditional values and natural sources. Obtained from beeswax, Apifil® CG is a moisturizing emulsifier that can be used for a wide range of cosmetic formulations, offering pleasant spreadability and ease of application, while contributing to skin hydration.
O/W emulsifier, made from natural beeswax, Apifil® CG promises efficacy in complete harmony with the skin. Beeswax helps to increase emulsion viscosity and improve spreadability. It enriches the oil phase of emulsions and improves after-feel, while also contributing to skin hydration by reducing moisture loss through the creation of a protective lipid film.
Lotions, supple creams, thick creams, and butters:
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Skin care—day and night applications
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Hair care—treatment masks, styling waxes
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Makeup—mascaras, foundations, lipsticks, pencils
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Sun care—protective sunscreen creams, aftersun preparations
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\n","actives":"","actives_secondary":"","textures":["sensorial_emulsifiers"],"textures_secondary":"","extract":false,"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/1724"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=1724"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/1724/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=1724"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=1724"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=1724"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"gattefosse-case-studies-pharmaceuticals-2":{"id":12124,"date":"2019-01-18T12:06:06","date_gmt":"2019-01-18T10:06:06","guid":{"rendered":"https://www.gattefosse.com/?page_id=12124"},"modified":"2021-04-08T09:14:08","modified_gmt":"2021-04-08T07:14:08","slug":"gattefosse-case-studies-pharmaceuticals-2","status":"publish","type":"page","link":"https://www.gattefosse.com/-voh/pharmaceuticals-panorama/gattefosse-case-studies-pharmaceuticals-2/","title":{"rendered":"Gattefosse Case studies for Pharmaceuticals"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"Learn how to formulate with Gattefossé excipients with our case studies"},"categories":[62],"tags":[],"acf":{"content_not_translated":true,"equivalent_fr":false,"equivalent_en":false,"component":"Panorama","title":"Gattefosse case studies for Pharmaceuticals","content":[{"wysiwyg":"
The aim was to develop dual SR matrix tablets by direct compression with an equivalent drug release profile to the two doses available as market references (500 and 750 mg).
\n
Keywords: dual matrix, sustained release, metformin hydrochloride, Compritol® 888 ATO, HPMC, direct compression, high drug load \n
The aim of this study was to develop a sustained-release tablet formulation using two SR agents, HPMC and Compritol® 888 ATO, in order to reduce the variations in drug release.
In this study, a design of experiment (DoE) was performed to assess the effects of emulsifiers and Transcutol® concentrations on emulgel appearance, pH, viscosity and stability after 24h, 1, 3, 6 and 12 months at 40°C.
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Due to the high molecular weight of Benzoyl Aconitine (603.7), formulating a transdermal patch is a challenge. Among all the tested permeation enhancers, Plurol® Oleique CC 497 showed the best results.
\n","link":"https://www.gattefosse.com:443/back/files/CS 202005 How to select the best permeation enhancer for benzoylaconitine transdermal patch.pdf"},{"image":{"id":18558,"alt":"tablets","title":"tablets","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30787.jpg","width":2724,"height":1804,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30787-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30787-300x199.jpg","medium-width":300,"medium-height":199,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30787-768x509.jpg","medium_large-width":474,"medium_large-height":314,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30787-1024x678.jpg","large-width":474,"large-height":314,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30787-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30787-1038x576.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":576}},"title":"Fenofibrate tablets with Gelucire® 44/14","text":"
The aim of this study was to prepare tablets by wet granulation using Gelucire® 44/14 to improve the dissolution of fenofibrate.
\n","link":"https://www.gattefosse.com:443/back/files/CS 2020 04 Fenofibrate tablets with Gelucire 44_14.pdf"},{"image":{"id":17367,"alt":"","title":"Woman with Patch on Arm","caption":"Woman with Patch on Arm","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","width":106,"height":150,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674-106x150.jpg","thumbnail-width":106,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","medium-width":106,"medium-height":150,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","medium_large-width":106,"medium_large-height":150,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","large-width":106,"large-height":150,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","post-thumbnail-width":106,"post-thumbnail-height":150,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","twentyfourteen-full-width-width":106,"twentyfourteen-full-width-height":150}},"title":"How to formulate a daphnetin transdermal patch with enhanced permeation? ","text":"
The aim of the study was to develop an optimized drug-in-adhesive patch with 1% daphnetin with good in vitro drug release and skin permeation. Backing films, permeation enhancers and permeation enhancer content were investigated through in vitro experiments.
\n
Keywords: transdermal patch, daphnetin, Transcutol® P \n
\n","link":"https://www.gattefosse.com:443/back/files/CS 2019_10_ How to formulate a daphnetin transdermal patch with enhanced permeation.pdf"},{"image":{"id":15607,"alt":"3D printing technology","title":"3D Printing line icons set","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/3d-printing.jpg","width":1593,"height":894,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/3d-printing-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/3d-printing-300x168.jpg","medium-width":300,"medium-height":168,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/3d-printing-768x431.jpg","medium_large-width":474,"medium_large-height":266,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/3d-printing-1024x575.jpg","large-width":474,"large-height":266,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/3d-printing-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/3d-printing-1038x576.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":576}},"title":"Are lipid excipients suitable for 3D printing?","text":"
The feasibility of preparing solid SEDDS using solid (Gelucire® 48/16) and semi-solid (Gelucire® 44/14) lipid excipients with a 3D printer is assessed using two model drugs, i.e. cinnarizine and fenofibrate.
\n
Keywords: 3D printing, Gelucire® 44/14, Gelucire® 48/16, fenofibrate, cinnarizine
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The aim was to develop dual SR matrix tablets by direct compression with an equivalent drug release profile to the two doses available as market references (500 and 750 mg).
\n
Keywords: dual matrix, sustained release, metformin hydrochloride, Compritol® 888 ATO, HPMC, direct compression, high drug load \n
\n","link":"https://www.gattefosse.com/back/files/How%20to%20obtain%20dual%20sustained%20release%20tablets%20by%20direct%20compression.pdf"},{"image":{"id":12312,"alt":"","title":"Gattefosse_30285","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30285.jpg","width":917,"height":864,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30285-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30285-300x283.jpg","medium-width":300,"medium-height":283,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30285-768x724.jpg","medium_large-width":474,"medium_large-height":447,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30285.jpg","large-width":474,"large-height":447,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30285-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30285-917x576.jpg","twentyfourteen-full-width-width":917,"twentyfourteen-full-width-height":576}},"title":"How to reduce drug release variability in HPMC-based sustained-release tablets ?","text":"
The aim of this study was to develop a sustained-release tablet formulation using two SR agents, HPMC and Compritol® 888 ATO, in order to reduce the variations in drug release.
\n","link":"https://www.gattefosse.com/back/files/How%20to%20reduce%20drug%20release%20variability%20in%20HPMC%20based%20sustained%20release%20tablets%20.pdf"},{"image":{"id":12179,"alt":"","title":"Gattefosse_27776","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776.jpg","width":2598,"height":1951,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-300x225.jpg","medium-width":300,"medium-height":225,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-768x577.jpg","medium_large-width":474,"medium_large-height":356,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-1024x769.jpg","large-width":474,"large-height":356,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-1038x576.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":576}},"title":"How to formulate a simple emulgel with a high level of Transcutol® P","text":"
In this study, a design of experiment (DoE) was performed to assess the effects of emulsifiers and Transcutol® concentrations on emulgel appearance, pH, viscosity and stability after 24h, 1, 3, 6 and 12 months at 40°C.
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Some APIs present poor organoleptic properties; therefore, taste or odor need to be masked. Others are sensitive to water, oxidation, or temperature and need to be protected to maintain stability. Certain lipid excipients are used in melt processes to effectively protect the API from degradation or mask taste and odor.
\n
\n
\n
Advantages of Gattefossé’s taste-masking and API protection agents:
\n
• thermoplastic behavior conducive to processes used (high shear coating, hot melt coating, granulation, extrusion, and capsule molding) • solvent-free process • chemically inert—highly compatible with other excipients in the formulation • plastic deformation for high resistance to compaction • lipid coating that does not impact bioavailability
Solvent and powerful solubilizer. Penetration enhancer for topical formulations. Safety of use and low irritancy inferred by numerous toxicological studies and precedence of use in approved topical medicines.
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excellent compatibility with pigments, for perfect coverage
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no heavy, greasy sensation on the skin
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Solvent and powerful solubilizer. Cosolvent in surfactant oral formulations—LFCS Type III (SMEDDS) and Type IV (micellar solutions). Vehicle in nasal and ophthalmic formulations. Safety of use and low irritancy inferred by numerous toxicological studies and precedence of use in approved pharmaceutical products.
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The eye contour is fragile and constantly in movement. This favors the formation of under-eye, tear trough, and crow’s feet wrinkles, which create facial expressions projecting sadness, fatigue, bitterness, and sternness. Reconnecting the epidermis to the dermis, Gatuline® Link n Lift acts on all eye contour wrinkles for a younger and fresher look: the face regains a rested, positive expression.
Gatuline® Link n Lift is the first active derived from the horse chestnut flower, rich in active molecules (i.e., flavonoids, tannins, amino acids, and sugars). It is obtained using Natural Deep Eutectic Solvents (NaDES) technology.
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NaDES yields active compositions unattainable with conventional solvents. Natural, nontoxic, and effective at low temperatures, NaDES is perfectly aligned with Gattefossé’s strategy to provide high-performance sustainable ingredients. The horse chestnut flowers are handpicked in Ardèche, France, for responsible sourcing.
acts deeply, in the dermis, mobilizing fibroblasts to help the skin fight matrix degradation;
\n
reinforces the integrity and function of the dermal-epidermal junction by stimulating the synthesis of all major components involved in dermis-epidermis cohesion and communication.
At a use level of 2%, Gatuline® Link n Lift visibly acts on all eye contour wrinkles—crow’s-feet, undereye wrinkles, and tear trough wrinkles. A double- blind study with a placebo control has confirmed this eye contour rejuvenation: the first effects are apparent in just two weeks. Wrinkles are visibly reduced, and the skin is toned and smoothed.
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A nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs. Self-emulsifies in aqueous media forming a fine dispersion, i.e., microemulsion (SMEDDS).
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Stearoyl polyoxyl-32 glycerides
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Stearoyl macrogol-32 glycerides
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G6EP177239
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PEG-32 HYDROGENATED PALM GLYCERIDES
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Polyoxylglycerides
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Consists of mono, di- and triglycerides and PEG-32 (MW 1500) mono- and diesters of palmitic (C16) and stearic (C18) acids
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into coarse emulsion—LFCS Type III (SMEDDS). Modulation of drug release. Lipid binder in melt processes. Safety of use is inferred by toxicological data and precedence of use in approved pharmaceutical products.
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