Publications on lipid-based formulations

List of Gattefossé publications on lipid-based formulations.

Understanding The Role Of In Vitro And In Vivo Evaluation Techniques In Determining the Performance of Lipid-Based Formulations


In this case study using curcuminoids as model drug, the authors show that in vitro lipolysis test is a useful tool to predict in vivo performance

Poster CRS 2019

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Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs

Kapilkumar Vithani, Vincent Jannin, Colin W. Pouton, Ben J. Boyd

In this review article, the authors explain the importance of the colloidal structures formed during dispersion and digestion of self emulsifying lipid-based formulations on drug solubilization and absorption.

A review of the techniques used to characterize the colloidal structures is also carried out.

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Complex Interplay between Solubilization, Digestion, Supersaturation and Absorption of Poorly Soluble Drugs with Lipid-Based Formulations

Vincent Jannin
Current Drug Delivery,2018,15,749-751

A Systematic Approach to Lipid-Based Formulation Development for a Poorly Soluble API, Fenofibrate

Masumi Dave, M.S., Jason Le Pree, Ph.D., R.Ph.

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Macrogol esters: Influence on in vitro and in vivo dissolution of a poorly soluble drug

Chhanda Kapadia, Meenakshi Venkataraman, Megha Marwah , Nabil J Farah , M.S. Nagarsenker

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Gelucire 48/16®: A Non-Ionic Solid Surfactant for Solubility Enhancement of Poorly Soluble Drugs

Chhanda Kapadia, Agnivesh Shrivastava, Sharda Gurram

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LIPID-BASED DELIVERY – Are Lipid-Based Drug Delivery Systems in Your Formulation Toolbox?

Dr. Jason LePree Drug Development & Delivery, Issue: October 2017, Posted Date: 9/29/2017 This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome impediments to good bioavailability of therapeutic actives, including poor water solubility, low permeability, and degradation by stomach acid or enzymes in vivo.

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Gelucire® 48/16: a solid surfactant for tablets

Ketkee Deshmukh and Chhanda Kapadia Pharma Times, Vol. 48 – N° 11 – November 2016 – pp 17-22 This articles describes Gelucire® 48/16 – a novel pegylated lipid excipient, and its use as a solid surfactant for solubility enhancement.

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Novel Pegylated lipid excipients: Role in augmenting dissolution of a poorly soluble drug.

  AAPS 2016

This poster describes the use of Gattefossé’s newest surfactant Gelucire® 48/16 (polyoxyl stearate type I USP-NF) and our hydrodispersible lubricant Compritol® HD5 ATO (behenoyl polyoxyl-8 glycerides USP-NF) in tablets of telmisartan, a BCS class II drug.

Gattefossé excipients were combined with API in granulation processes and granules were compressed into tablets. Tablets of good quality and integrity were made and drug release was compared with a market reference product. Results showed improved drug dissolution in tablets made with Gelucire® 48/16 and Compritol® HD5 ATO.


Solidification of liquid self-emulsifying lipid formulations by loading on solid mesoporous carriers

Vincent Jannin; Stéphanie Chevrier; Cédric Miolane; Margaux Metin; Hamza Benhaddou; Yann Chavant; Fred Monsuur; Frédéric Demarne AAPS 2016 Log-in to download the poster

Maisine® CC, a unique pharmaceutical oil for solubility and oral bioavailability enhancement

October 2016 This white paper features Maisine® CC (glyceryl monolinoleate NF), a unique pharmaceutical oil that has a long and successful history of use in lipid-based formulation for drug solubilization and oral bioavailability enhancement. Access the publication

Reaching milestones in lipid-based formulations: from effective prediction to successful development

September 2015 This white paper describes the important milestones achieved in lipid based formulation (LBF) development for oral drug delivery. Collaborative research between academic and industrial partners has increased understanding of the functional properties of lipid excipients and the role they play in solubilizing poorly water soluble compounds. It has also led to the development of in vitro – in vivo predictive analytical tools. The key scientific articles describing these milestones are collected in this one White Paper, providing a single source of practical information for those interested in lipid formulation development. Access the publication

Development of self emulsifying lipid formulations of BCS class II drugs with low to medium lipophilicity

Vincent Jannin, Stéphanie Chevrier, Matthieu Michenaud, Camille Dumont, Silvia Belotti, Yann Chavant, Fédéric Demarne.

This acticle describes the work undertaken in Gattefossé R&D labs (St Priest) to develop lipid formulations for low to medium lipophilicity API: piroxicam, nifedipine and curcurmin and evaluate the effect of in-vitro digestion on the solubilizing capacity of the formulations.

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Formulation of a self-emulsifying lipid formulation of curcumin

Vincent Jannin, Camille Dumont, Hamza Benhaddou, Stéphanie Chevrier, Yann Chavant, Christophe Voutsinas, Frédéric Demarne

AAPS 2014

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Establishment of a binary phase diagrams database for the development of self-emulsifying lipid-based formulations

Jannin, Vincent; Benhaddou, Hamza; Dumont, Camille; Chevrier, Stéphanie; Chavant, Yann; Demarne, Frédéric 

AAPS 2014

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Self-formulation protocol: Part I: Solubility determination in liquid and solid excipients

Jannin, Vincent; Michenaud, Mathieu; Belotti, S.; André, C.; Chevrier, Stéphanie; Chavant, Yann et al. (2013).
AAPS Annual Meeting and Exposition. San Antonio, 2013.

Solubility screening is detailed in both liquid and (semi) solid excipients, to select excipients with highest solubilizing capacity.

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Self-formulation protocol: Part II: excipient selection, diagram design and selection of prototype formulations.

Jannin, Vincent; Michenaud, Mathieu; Belotti, S.; André, C.; Chevrier, Stéphanie; Chavant, Yann et al. (2013)
AAPS Annual Meeting and Exposition. San Antonio, 2013.

Dispersion test and ternary diagramming are detailed, to determine the excipient ratios and prototype formulations

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Self-formulation protocol: Part III: impact of lipolysis on prototype formulations.

Jannin, Vincent; Michenaud, Mathieu; Belotti, S.; André, C.; Chevrier, Stéphanie; Chavant, Yann et al. (2013)
AAPS Annual Meeting and Exposition. San Antonio, 2013.

Lipolysis test is used to determine the capacity of prototype formulations to maintain drug in solubilized state.

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