Excipients for lubrication

During tablet and capsule production, lubricants are necessary to improve powder flow and reduce friction and adherence. Lubrication is a critical step since over- or underlubrication is responsible for many production and quality issues. Therefore, lubricant type, quantity, and conditions of use are critical parameters to take into account when developing a formulation.

Advantages of Gattefossé lubricants:

Gattefossé lubricants are recommended for challenging formulations. They are also able to resolve production and quality issues due to these qualities:

  • chemical inertness: no reactive groups and no incompatibility with APIs or other excipients
  • robustness: resistant particles of homogeneous size ensure constant surface area; mixing time and speed do not change the quality of the lubrication or tablet properties
  • effective lubrication that preserves tablet attributes: hardness, disintegration time, and drug release

Range of lubricants:

Compritol® 888 ATO for challenging pharmaceutical tablets:

  • highly reproducible spherical particles having a mean size of 50 µm
  • well-defined, highly reproducible plant-based composition
  • recommended for use at proportion of 1%–3% (w/w)
  • inertness with no reported incompatibility with APIs
  • lubrication unaffected by mixing time and speed
  • GRAS status and precedence of use with many APIs (FDA IID)

Compritol® HD 5 ATO for water dispersible tablets:

  • highly reproducible spherical particles having a mean size of 50 µm
  • well-defined, highly reproducible composition including PEG esters to increase aqueous solubility and dispersion properties
  • recommended for use at proportion of 1%–3% (w/w)
  • can also be used in orodispersible or effervescent tablets

Precirol® ATO 5 for powder capsule filling;

  • highly reproducible spherical particles having a mean size of 50 µm
  • well-defined, highly reproducible plant-based composition
  • improved powder blend flow due to glidant properties
  • recommended for use at proportion 1%–3% (w/w)
  • GRAS status and precedence of use with many APIs (FDA IID)

Compritol® E ATO for challenging nutraceutical tablets:

  • highly reproducible spherical particles having a mean size of 50 µm
  • well-defined, highly reproducible plant-based composition
  • recommended for use at proportion of 1%–3% (w/w)
  • inertness; no reported incompatibility with nutraceutical actives
  • effective lubrication at low concentration even with high-dose tablets
  • easy to formulate: lubrication unaffected by mixing time and speed
  • GRAS and food additive status (EU, USA, Japan)

Biogapress™ Vegetal BM 297 ATO for nutraceutical powder capsule filling:

  • highly reproducible spherical particles having a mean size of 50 µm
  • well-defined, highly reproducible plant-based composition
  • recommended for use at proportion of 1%–3% (w/w)
  • improved powder blend flow due to glidant properties
  • GRAS and food additive status (EU, USA, Japan)

RELATED DOCUMENTS