Gattefossé has mapped all of its direct and indirect carbon emissions by responding to the CDP assessment on climate change, which applies to the perimeter of its Saint Priest site (Gattefossé Headquarters).
In December 2020, Gattefossé obtained a B score for its actions, a result higher than the European average and higher than the average for companies in the chemical sector, which is C.
“The assessment provided by CDP gives us a better understanding of where we need to focus our attention and encourages us in our continuous climate improvement process. The score obtained for 2020 reflects the company’s commitment at the highest level on this crucial subject. It is also the result of a team effort that has mobilized many employees, partners and suppliers, and we would like to thank them. It is thanks to their involvement and all of their actions that we will continue to make progress” explains Anthony Bailleul, Sustainable Development Engineer at Gattefossé.
To know more about the CDP: https://www.cdp.net/en/
\n
Let’s now discover the Glittering Gummies (2745-3.04), a surprising travel-friendly format for a highlighter, made possible by Emulium® Kappa MB! Compact and easy to carry, this solid O/W emulsion is perfect for touch-ups on the go.
\nIt offers an ultra-bouncy effect and melting sensation thanks to Lipocire® A SG and creates a fresh and watery effect upon application.
\n (97.4% natural origin)
\n
Craving uniqueness? The Holo Eye Liner (2758-1.11) has been designed to reveal the eccentricity living in you while reamining smudge-free and waterproof. Creamy and quick-drying, it melts seamlessly thanks to Lipocire® A SG to leave an intense purple, holographic line with long-wear properties! Emulium® Dolcea MB shows unfailing efficiency and robustness with this formula rich in pigments.
\n (92% natural origin)
\n
What if everyday life became a playground (again)? Gattefossé encourages more playful cosmetic application with our Cottage Cheese cream (2748-1.11) and its Squid Ink Topping (2748-2.04)! With Emulium® Dolcea MB, Acticire® MB, and EnergiNius® this creamy, yogurt-like texture delivers moisturizing and energizing benefits, perfect for daily application. Recommended once a week or once a month, mix it with 2 drops of the Squid Ink Topping, enriched with Original Extract® Ginger, to create your own detox mask!
\n (99.5% natural origin)
\n
It’s time to discover new territories! Between the real and imaginary, appearances can be misleading…
\n Like the Chayote-Kiwi Sorbet (2694-3.03), is it a beauty sorbet or a granita? With its light green color, you first see a food-like texture that you would love to eat. Upon initial application, you’ll feel a fresh, creamy yet powdery sensation, that leaves a dry, soft, non-tacky after-feel due to Emulium® Mellifera MB. This cushion cream brings a refreshing and intense moisturization, acts as a blur, and protects the skin from photoaging with Solastemis™. The skin appears radiant, even, and healthy.
\n (99.4% natural origin)
\n
Alien Slime (2614-3.01) is another optical illusion! is it slime, or is it a cosmetic? Try it and you’ll be surprised by its comfortable, stringy, but non-sticky after-feel thanks to Emulium® Dolcea MB & Acticire® MB.
\nAdapted for sensitive skin, it has a long playtime which is perfect for a soothing massage! It can also be used as a leave-on so that you can appreciate its nourishing properties.
\n (98.2% natural origin)
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calendar of events | Trade shows, congresses, seminars…","_yoast_wpseo_metadesc":"Our teams will be glad to meet you during trade shows, seminars and congresses. Discover the dates of our next events worlwide."},"categories":[20],"tags":[],"acf":{"component":"PageEvent","":false,"events":[{"section":"pharmaceuticals","zone":"europe","title":"Latest outcomes from ex vivo and in vivo studies with Labrasol® ALF and Labrafac™ MC60, intestinal permeation enhancers","date":"7 & 9 March 2023","location":"on line","type":"","description":"Join us for our webinar, in which Dr. Fiona McCartney shares her latest ex vivo and in vivo results from a Gattefossé sponsored study, at University College of Dublin, that assessed the efficacy of Labrasol® ALF and Labrafac™ MC60 as transient intestinal permeation enhancers.Definicire® is an active texturizing agent that recreates the hair protective lipid layer. 100% natural, based on functionalized jojoba and sunflower seed waxes, it ensures perfect hair discipline in all climates, and a comfortable smooth feel.
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Silicones and quaternary compounds are the main cosmetic ingredients used as hair conditioners. They are both efficient, in different ways, but have limitations regarding biodegradability, build-up effect and image. In addition, they are not natural and are unlike the complex hair lipid layer.
\nGattefossé has placed its expertise in lipid chemistry at the service of haircare.
\n Definicire® is a unique ingredient obtained by transesterification of jojoba wax and sunflower seed wax in presence of polyglycerol. Its composition has been optimized to recreate the performance of sebum and 18-MEA which are known to provide naturally the best protection of the hair.
Healthy hair is hydrophobic. Definicire® reinforces the hydrophobicity of the hair. It acts as a lubricant decreasing friction between hair fibers and improves hair quality in both dry and humid conditions.
\n\n
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Gattefossé has developed Emulium® Kappa MB to answer formulators’ need for a multifunctional PEG-free emulsifier of natural origin that yields stable emulsions; offers the added value of greater activity; and creates a unique sensorial identity.
\nOil-in-water emulsions based on Emulium® Kappa MB are very glossy and have a rich and luxurious feel. They are easy to apply, have a long play time, create a sensation of comfort, are softly textured (comparable to silicone elastomers), and exert a remarkable, lasting cushion effect—for baby-soft, replumed skin.
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\n
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An extract is only as good as the raw material it originated from. So we begin at the planting stage, through a responsible commitment that involves all parties in the production chain, including farmers, harvesters, dyer-conditioners, traders, and transporters. Gattefossé goes above and beyond adherence to specifications and preservation of traceability: it cares about fair trade and both socioeconomic and environmental consequences. We ensure that our raw material supply chain is sustainable and worthy of trust.
\n
Recently, the acquisition and development of Natural Deep Eutectic Solvent (NaDES) technology has leveraged our capacity to manufacture extracts with high substantiated efficacy. A pioneer in the use of NaDES technology, Gattefossé is now able to offer innovative yet totally natural products, based on plants or flowers. See our latest launch, Gatuline® Link n Lift.
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A SG","tagline":"Sustainable texturizing","description_product_finder":"","introduction":"This waxy compound has a very good affinity with the skin’s hydrolipidic film. It has a melting point close to skin temperature and delicately melts on the skin, offering comfort, softness, and a unique sensorial experience.
\n","use_level":"2-10%","naturalite":"ECOCERT / COSMOS approvedLipocire™ A SG is composed of 100% RSPO segregated sustainable palm and palm kernel oils. The fruit of the palm tree has dark red skin and yellow-orange flesh, and it is particularly rich in nutrients. The pulp of the fruit and the almond within its kernel both have a high triglyceride content (>50%).
\nUnique composition obtained by interesterification. Other grades available:
\nSensory profile:
\nProperties:
\n\n","applications":"
Discover or rediscover our wide range of botanicals. Oily or water-soluble, they bring a natural touch to any cosmetic formulation.
\n","use_level":"Depending on references","naturalite":"","inci":"31 referencesWe select the most appropriate manufacturing method and extraction medium for each plant. Gentle, prolonged maceration to help maintain the integrity of active plant components is followed by several filtration stages before final sterilization. Available references: Aloe, Arnica, Bearberry, Birch Tree, Calendula, Carrot, Common Nettle, Cornflower, Cucumber, Ginkgo Biloba, Ginseng, Grapefruit, Henna, Horse Chestnut, Horsetail, Hydrocotyl, Ivy, Lavender, Lemon, Lotus, Mallow, Matricaria, Oat, Quillai, Red Grapevine, Rose, Sage, Seaweed, Wild Pansy, Witch Hazel, Yeast.
\nDepending on references:
\nYou’ve heard it before – the natural market is continuing to grow. According to a recent study by Grand View Research1, the global organic personal care market is expected to reach $25B by 2025, with 9% annual growth.
\nThis growth is being driven largely by consumers’ growing focus on health and wellness, by the growing availability of new and better natural products, and by the millennials, who embrace natural and sustainable concepts more than previous generations.
\nCheck our our 5 top things to keep in mind when diving into natural formulating.
\n\n
With so many natural certifications out there, deciding where to start can be a real challenge; but it’s an important first step to guide you through the formulating process. Here we break down the most popular green and natural certifications and claims.
\nFor a list of Gattefossé certified natural ingredients, click here.
\n#2 It’s a moving target
\nWhile just a few yeas ago, natural cosmetics focused strictly on incorporating natural ingredients, today the scope of natural continues to broaden. In recent years, we’ve seen a sharp rise in vegan cosmetics, for example.
\n\n\n\n
We also see companies taking sustainability and corporate social responsibility into account with more focus on creating a product that is good for the environment and society at every step from consumption to sue.
\nLastly, new issues are coming to light every day. Just recently, Hawaii has decided to crack down on sunscreen ingredients that have the potential to harm coral reefs.2
\n\n
All of these considerations are important factors of success in today’s market because millennials are deeply invested in these causes. This generation has a broad view of natural and environmental topics and they are very close to them – they’ve grown up being told that the earth is in danger, that climate change is an imminent problem, that overpopulation and over pollution are having a serious effect on this planet, and as a result, they see it as their responsibility to affect change and they take their beliefs with them into all of their consumption habits from furniture, to clothes, to cosmetics.
\nBy the numbers:
\n\n
Many formulators still believe that formulating natural cosmetics is too difficult, or that natural products can’t meet the aesthetic and active standards of traditional formulation.
\nWhile it’s true that creating an all-natural formulation can limit your ingredient choices, the good news is that as the market for natural products has grown, so has the availability of natural ingredients. Today, one can find excellent natural emulsifiers, actives, surfactants, and even preservatives that deliver activity, sensory experience, and functionality comparable to that of standard ingredients.
\n\n
Since our beginning in 1880, Gattefossé has been a leader in natural and sustainable cosmetic ingredients. Our two areas of expertise, oleochemistry and plant extraction lend themselves to natural solutions.
\nToday, our range consists primarily of certified natural ingredients and our commitment to sustainability is stronger than ever. Our ready-made prototypes and global application labs can also help you on your journey to better natural products.
\nUse our Product Finder to discover natural ingredient solutions or
\n Get in Touch to learn more about how Gattefossé can help.
Emulium® Dolcea MB is a PEG-free O/W emulsifier of 100% natural origin, easy to formulate and flexible which creates from fluid textures to thick butters.
\nEmulium® Dolcea MB shows high compatibility with cosmetic ingredients and provides excellent stability alongside natural gelling agents.
\nWith immediate and long-lasting moisturizing power, this ingredient brings functionality and efficacy to a wide range of applications.
\nFeaturing a strong sensory signature, it brings extreme softness to cosmetic emulsions. COSMOS approved, Emulium® Dolcea MB can be used in organically certified, vegan and readily biodegradable formulations.
\n","use_level":"3-5%","naturalite":"Worldwide approval for cosmetic applicationsGattefossé pushed the limits of its patented wax butter technology to develop the most advanced and robust version of Gattefossé ingredients from wax butters, Emulium® Dolcea MB.
\nJojoba and sunflower waxes used in Emulium® Dolcea MB react with vegetable polyglycerol to create a 100% natural origin O/W emulsifier, which bring moisturizing benefits due to the vegetable waxes and true sensory identity.
\n\n
\n","origin_video":"","key_benefits_carousel":[{"content":"
Formulation:
\nEmulium® Dolcea MB can be added to the oil phase preferentially, or to the water phase if necessary. Robust, it is capable of emulsifying and stabilizing emulsions with up to 40% of oil phase. In the form of pellets, it is very easy to formulate, does not require high shear mixing and enables the creation of very fine emulsions (5-10 µm).
\nDifferent formulation processes:
\nExtreme softness:
\nImmediate and long-lasting moisturizing properties:
\nBiodegradability:
\nA high-purity solvent for oral, topical (spot-on, pour-on) and parenteral veterinary medicines. No Maximum Residue Limit for use in food-producing animals.
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\nSoon after, SFPA left the Monchat district of Lyon for the neighboring city of Villeurbanne. A huge factory was built, housing a dozen workshops and laboratories fitted with state-of-the-art equipment. Alongside the factory buildings, there was a garden for aromatic crops which functioned as a nursery where half-scale testing could be carried out.
\nThe business started to see excellent results not long after moving to the new premises. At that time, perfumery was still the company’s primary activity. The business had developed relationships with suppliers all over the world; it imported clove oil and cinnamon essence from Madagascar, niaouli and star anise essential oils from Indochina, and cedarwood oil from Morocco. Rose oil came from Bulgaria and mint oils from America. Advertisements said the SFPA “only worked with the purest and most refined products”. Customers could purchase the Argos range, a collection of citrus essential oils from Sicily (lemon, orange, bergamot, etc.), several products made from blended raw materials, and so-called “artificial” fragrances such as “Lotex” (violet, jasmine, quinine and mimosa) and “Taylor” (acacia, white rose and oregano). As throughout the previous decade, René-Maurice wrote publications to accompany Gattefossé products as they were brought to market. He wanted to help customers use synthetic raw materials in the most effective way.
\nAt the same time, the SFPA started developing an efficient network for the business by opening a number of offices around the world. René-Maurice’s nephew, Louis Schmuck was put in charge of the Paris office, and his younger brother Jean was entrusted with prospecting for new plant species in Morocco and the colonies.
\nJean also became Editor-in-Chief of La Parfumerie Moderne, which continued to spread its “propaganda” throughout the world of French perfumery. The SFPA also directly benefited from valuable information published in the magazine about the raw materials used to create its products. Eminent botanists published the results of their work in the pages of La Parfumerie Moderne. And René-Maurice continued to contribute articles promoting the therapeutic properties of essences, although his readership was limited. The decade drew to a subdued close. The SFPA embarked on a full-scale diversification initiative that was undoubtedly too ambitious, and results proved disappointing to shareholders. While the business was producing aromatic compositions such as Salvone and Nardol, it was also developing new product ranges that took the company’s trade in a different direction. Products included dyes for perfume and rice powder, necklaces containing fragrances, and even insecticides and veterinary dressings. The start of the Great Depression in 1929 did not help matters, and in 1930, several stockholders asked to pull out. René-Maurice offered to buy back their shares, but to do so, he had no other choice than to sell the factory in Villeurbanne and significantly downsize the business.
\n
In 1931, the business was once more owned entirely by the family. But independence came at a high price: the SFPA was forced to retreat to Monchat, where the premises were much more cramped, and just twenty or so employees kept up the manufacture of perfume and cosmetic compositions.
\nThe arrival of a new generation marked a turning point for the business. René-Maurice’s son Henri-Marcel Gattefossé (who went by the name Marcel) and son-in-law Émile Mahler both joined the company as chemists (see picture). After meeting Doctor Jonquières, Marcel contributed to the development and manufacture of veterinary products and then dermatological materials, while Émile started producing emulsified excipients, introducing lipid chemistry and formulation to the business. This was a key period in the history of Gattefossé because it largely determined the organization’s direction over the decades to come, and still today, lipid chemistry is central to the company’s activities.
\nGattefossé’s “new generation” excipients produced from fatty acid esters (glycerol monostearate) would go on to be of interest to both the cosmeticand pharmaceutical sectors and were initially used in hospitals. In fact, from 1938, Marcel tested new emulsified creams invented by Émile at the Antiquaille hospital in Lyon, working in the syphilis department run by Professor Jean Gaté. The creams proved to be excellent substitutes for Vaseline and other types of petroleum jelly and marked the company’s first steps in dermatology.
\nIn the same department, at the same time, René-Maurice was experimenting with the therapeutic effects of essential oils, and was also using his son-in-law’s emulsified excipients in his preparations. At that time, René-Maurice had not long published a book entitled L’Aromathérapie, a term he invented. The publication included a report on the work he had carried out over the previous twenty years and analysis of scientific, chemical and pharmacological data available on aromatherapy. Towards the end of the 1930s, he conducted an increasing number of clinical trials, looking ahead to a second edition. However, it never saw the light of day.
\nWhile the company was pursuing dermatological activities and collaborating with hospitals, it started to increase the amount of work it was carrying out in the cosmetics sector until that became the strongest part of the business. The SFPA sold bases for creams and lotions, plus raw materials for use in hair products, make-up including powders and lipstick, face masks and even toothpaste.
\nHowever, development came to a halt at the start of the Second World War. Both Marcel and Émile were enlisted. In 1940, wanting to ensure the company had sufficient supplies, René-Maurice purchased a farmhouse near Saint-Rémy-de-Provence, where he grew lavender, mint, sage and other aromatic herbs. He also found this to be a suitable environment for writing numerous works on cosmetics, and as the war came to a close, cosmetics continued to be an important part of the company’s research.
\nIn 1946, Marcel and René-Maurice saw their research developments come to fruition when they were issued a patent for the manufacturing processes developed to create the creams tested at the Antiquaille hospital. That same year, the SFPA firmly established its credibility in the field of cosmetics when it was granted a further patent for a type of hair oil. In 1949, the growing importance of the cosmetics market was highlighted once more with the creation of the Société Française de Cosmétologie, with Louis Schmuck as secretary-general.
\nOn 21st April 1950, René-Maurice was visiting his brother Jean in Casablanca, Morocco, when he died suddenly from a pulmonary edema. His widow, Blanche, was named company Chair, his son Marcel became Managing Director and his son-in-law Émile was made Technical Director.
\n\n
Gattefossé’ successive leaders have always been talented, curious, open-minded scientists, combining their expertise in plant extraction and lipid chemistry to create innovative products for the cosmetic and pharmacy industries. René-Maurice Gattefossé, Henri-Marcel Gattefossé, and Emile Mahler all strongly believed in the power of collaborative work and nurtured strong relationships with professional partners, academicians, and collaborators. Today, the company works at perpetuating this legacy and is proud of its rich corporate culture, influenced by the characters of its founders.
\nGattefossé is a modestly sized company, so we know how the personal investment of each employee advances the success of the group as a whole. Our company’s growth relies on the coordinated daily efforts of all our staff around the world, who share a common vision for the future.
\n\n
Gattefossé invests in its employees to keep them at the forefront of their fields.
\n
In accordance with French legislation, Gattefossé has calculated its Professional Equality Index for its major entity in France, Gattefossé SAS: at the end of 2020, the result is 89/100 :
\n\n
\n
\n
\n
“My priorities are clearly linked to further securing the future of Gattefossé by expanding to new locations, pursuing R&D efforts, and forging additional strategic alliances.
These goals are closely connected to my vision, summarized by the following tenets of our company’s family culture:
\n\n
Jacques Moyrand and his wife, Sophie Gattefossé-Moyrand, also created the Gattefossé Foundation in 2008, with the desire to perpetuate Gattefossé’s founders’ vision and values by serving a long-term general interest.
The Foundation’s purpose is to promote the scientific and clinical use of essential oils as a complementary therapeutic approach to health, primarily within hospital settings.
\n\n\n
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This advanced 3D model has been successfully used to measure the efficacy of EleVastin ™, which claims to fight sagging skin. It is particularly suitable for measuring the density of elastic fibers and the elastic properties of the skin in vitro.
\nBioMeca supports the personal care and pharmaceutical industries to better understand the mechanisms of action of active ingredients, finished products and therapeutic molecules.
\n\n\n
\n
Nicolas Bechetoille, skin biology research manager at Gattefossé, explains the reasons behind this collaboration.
\n\n
\n
What are the challenges in your business today?
\nDevelop cosmetic active ingredients of plant origin, effective and differentiating. This differentiation goes through several channels: scientific innovation, the technical approach (new model, new measure), or a new association of biological activities to support a new discourse.
\nHow does the BioMeca solution help you meet these challenges?
\nWe have developed a new efficacy test with spheroids. We lacked the functional biomechanics approach to validate our model as a whole; this is where BioMeca was able to provide us a solution.
\nWhy did you trust the BioMeca solution?
\nBioMeca offers very fine expertise requiring cutting-edge tools that cannot be found anywhere else.
\n\n
\n
You want to know more ? Read the press release.
\n","link_all_news":"https://www.gattefosse.com/news-3","component":"PageNewsCorporate","thumbnail":{"id":23489,"alt":"","title":"BioMeca_266x232","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/03/BioMeca_266x232.jpg","width":266,"height":233,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/03/BioMeca_266x232-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/03/BioMeca_266x232.jpg","medium-width":266,"medium-height":233,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/03/BioMeca_266x232.jpg","medium_large-width":266,"medium_large-height":233,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/03/BioMeca_266x232.jpg","large-width":266,"large-height":233,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/03/BioMeca_266x232.jpg","post-thumbnail-width":266,"post-thumbnail-height":233,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/03/BioMeca_266x232.jpg","twentyfourteen-full-width-width":266,"twentyfourteen-full-width-height":233}}},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/23486"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=23486"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/23486/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=23486"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=23486"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=23486"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"locations":{"id":1209,"date":"2017-03-16T09:29:48","date_gmt":"2017-03-16T09:29:48","guid":{"rendered":"http://217.109.87.212/front/?page_id=1209"},"modified":"2023-02-01T10:46:57","modified_gmt":"2023-02-01T08:46:57","slug":"locations","status":"publish","type":"page","link":"https://www.gattefosse.com/fr/corporate-map/locations/","title":{"rendered":"Carte du monde"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Où nous trouver | Contactez votre représentant Gattefossé le plus proche","_yoast_wpseo_metadesc":"Présents dans plus de 60 pays, n'hésitez pas à contacter l'équipe d'experts techniques et marketing la plus proche de vous. "},"categories":[51],"tags":[],"acf":{"title":"NOS FILIALES ET NOS DISTRIBUTEURS DANS LE MONDE","description":"L’une des forces motrices du développement de Gattefossé est sa présence internationale. Grâce à un réseau commercial réactif et hautement qualifié, nous offrons à nos clients un service de qualité avec une approche locale propre à leurs marchés. Pour trouver le représentant Gattefossé le plus proche de chez vous, veuillez vous reporter à la carte ci-dessous.Gattefossé Group created Gattefossé Do Brasil in 2012, a worldwide affiliate located in São Paulo. The objective of this entity is to reinforce Gattefossé’s presence in Latin America, a growing market and a place for opportunities for both personal care and pharmaceutical ingredients. Lead by Mrs Amanda Botelho Pimentel, Gattefossé Do Brasil supports Gattefossé’s distributors in this promising territory, and facilitates contacts with all customers in Latin America. With the help of both its pharmaceutical and personal care distributors, Gattefossé has now the capacity to support its customers more efficiently, by making its technical and marketing expertise locally available to its customers.
\n","image":false,"zone":"america","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Canada","name":"Gattefossé Canada ","event_link":"https://www.gattefosse.com/fr/corporate-events/events/","position":{"address":"","lat":"43.68848838417244","lng":"-79.58850145339966"},"production_site":"Gattefossé Canada Inc. ","address":"170 Attwell Drive – Suite 580Gattefossé Canada Inc. was established in 1997 to service Personal Care, Pharmaceutical and Nutraceutical industries in Canada. Since its creation, this unit has demonstrated key competencies to growing the presence of Gattefossé as provider of innovative solutions involving its performance ingredients. Under the leadership of Eric Brun, Ph.D., our specialized team (marketing and technical support, customer service) is fully committed to servicing our customers from our locations (offices and warehouses) in Montreal and Toronto.
\n","image":false,"zone":"america","website":""},{"section":["personal_care","pharmaceuticals","application_laboratory"],"type":"affiliate","country":"Chine","name":"Gattefossé China ","event_link":"https://www.gattefosse.com/fr/corporate-events/events/","position":{"address":"","lat":"31.02234042904364","lng":"121.7669677734375"},"production_site":"Gattefossé China Trading Co. Ltd","address":"Room 5301, Building No. 5,公司起源 嘉法狮中国成立于2007年,公司办公室位于上海浦东的张江高科园区内。 自成立以来,嘉法狮中国一直致力服务于本地的个人护理品和药品生产行业,通过推广高质量新型辅料和创新应用,不断开发出符合消费者需求的个人护理产品和药品,深受本地行业和消费者的欢迎和认可。 为了更好地支持本地客户对产品创新应用的需求,嘉法狮中国投资建立了产品配方应用实验室,并拥有经验丰富的技术团队和较完善的仪器设备,为客户的项目开发服务。此外,嘉法狮中国的技术团队和实验室也组织各种理论和实用培训,并和法国总部协作,制备各种与全球领先趋势一致的配方样品,支持我们的商务团队取得持续的业务增长和成功。 嘉法狮中国拥有一支有10位经验丰富的专业人士组成的高效团队,支持两家个人护理品和一家药品的经销商不断取得成功。这三家经销商,分别在上海,广州和天津设有办事处。 嘉法狮将会持续投资中国市场,不断参与各种专业组织,论坛,展览会等,实现与中国一起长期成长的承诺。
\n","image":false,"zone":"asia_pacific","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"France","name":"Gattefossé France","event_link":"https://www.gattefosse.com/fr/corporate-events/events/","position":{"address":"","lat":"48.885159995263706","lng":"2.261037289572414"},"production_site":"Gattefossé France","address":"Gattefossé FranceCréé en 1993 et adapté aux spécificités du marché français, Gattefossé France a toujours marqué sa volonté de s’engager aux côtés de ses clients en allant au-delà de son rôle de fournisseur de matières premières. Gattefossé France a notamment structuré son offre de manière à allier intimement besoins en formulation et démarche créative, pour accompagner cosmétologues et galénistes dans la globalité de leurs problématiques.
\nLes ingrédients Gattefossé, issus de savoir-faire en oléochimie et extraction biologique, ciblent les besoins clients aussi bien en cosmétique qu’en pharmacie humaine et vétérinaire.
\n Les polymères texturants de Lubrizol Life Science et les esters de sucrose émulsifiants de Mitsubishi Chemicals complètent efficacement cette offre sur le territoire français.
Sous la direction de Thierry Magnet, une équipe dynamique d’une vingtaine de personnes de formations pluridisciplinaires met tout en œuvre pour satisfaire les exigences de ses interlocuteurs, chercheurs et marketeurs. Sa priorité ? Transformer vos idées en produits pertinents.
\nA découvrir :
\nLe magazine addiactive, source d’inspiration et d’idées actives pour la cosmétique. Inscrivez vous sur https://www.gattefosse.com/fr/personal-care-trends/addiactive-magazine
\n Le site de notre commettant Lubrizol Life Science : https://www.lubrizol.com/Personal-Care
Die Gattefossé Deutschland GmbH betreut seit 1989 Kunden der Kosmetik- und Pharmaindustrie in Deutschland und Österreich. Die deutsche Vertriebsniederlassung befindet sich in Eschbach im Gewerbepark Breisgau, der zentral im Dreiländereck Deutschland-Frankreich-Schweiz liegt.
\nIn Ergänzung zu den eigenen innovativen Produkten der Gattefossé-Gruppe vertreiben wir im Kosmetikbereich Rohstoffe unserer langjährigen Geschäftspartner Lubrizol und Mitsubishi.
\nDas Gattefossé-Team verfügt über eine umfassende Expertise und unterstützt Sie bei der Realisierung Ihrer Pharma- und Kosmetik-Projekte. Wir teilen mit unseren Kunden unser anwendungstechnisches Know-how und garantieren eine vertrauensvolle und partnerschaftliche Zusammenarbeit.
\nGattefossé erkennt die Trends von morgen und entwickelt immer wieder neue Produkte und Marketingkonzepte. Die Bedürfnisse unserer Kunden stehen im Vordergrund.
\nDas Gattefossé-Team freut sich über Ihren Anruf oder Ihre Email an: infode@gattefosse.de
\n","image":false,"zone":"europe","website":""},{"section":["personal_care","pharmaceuticals","application_laboratory"],"type":"affiliate","country":"Inde","name":"Gattefossé India","event_link":"https://www.gattefosse.com/fr/corporate-events/events/","position":{"address":"","lat":"19.071948827022688","lng":"72.87676692008972"},"production_site":"Gattefossé India Pvt Ltd","address":"Equinox Business ParkGattefossé India is a decade run strategic supplier for cosmetics and pharmaceuticals companies in India. This Gattefossé affiliate is responsible for sales, marketing and technical service support throughout the Indian subcontinent. It sustains a profitable operation, supported by a professional team of business development, technical and customer service as well as administration managers. Gattefossé India extends extensive regulatory, toxicological support, technical and application guidance to the pharmaceutical and personal care customers. Various workshops, texture showcase and seminars are organised by experts for detailing benefits of Gattefossé products.
\n","image":false,"zone":"asia_pacific","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Italie","name":"Gattefossé Italia ","event_link":"https://www.gattefosse.com/fr/corporate-events/events/","position":{"address":"","lat":"45.5059935026097","lng":"9.1636423766613"},"production_site":"Gattefossé Italia S.R.L.","address":"Via G. Durando 38Gattefossé Italia è stata fondata nel 1960 per servire le Industrie Cosmetiche e Farmaceutiche Italiane. Dalla sua creazione, questa filiale ha conosciuto una costante crescita, dimostrando di possedere le competenze giuste per consolidare Gattefossé quale fornitore di soluzioni innovative, con ingredienti sempre più efficaci. Il nostro team di specialisti (marketing, tecnici, customer service), totalmente dedicato al servizio dei nostri clienti, opera dai nostri uffici di Milano col pieno supporto dei nostri Uffici e Laboratori Centrali di Lione e Parigi.
\n","image":false,"zone":"europe","website":""},{"section":["personal_care","pharmaceuticals","production_site"],"type":"affiliate","country":"Singapour","name":"Gattefossé Asia Pacific","event_link":"https://www.gattefosse.com/fr/corporate-events/events/","position":{"address":"","lat":"1.3310498636538042","lng":"103.74185800552368"},"production_site":"Gattefossé Asia Pacific Pvt Ltd","address":"8 Jurong Town Hall RoadGattefossé Asia Pacific, Singapore regional office is one of the latest setup within the Gattefossé group. The new entity with a core team of technical and commercial staff reinforces Gattefossé’s presence in the Asia Pacific region. The Singapore regional office works closely with distributors and logistics partners in the marketplace. The company identifies the need to evolve its operations to gain more speed and efficiency by making inroads into the South East Asian countries, Japan, South Korea, Taiwan as well as Australia and New Zealand. This enables Gattefossé to effectively service the customers in terms of technical support and commercial requirements for both Personal Care and Pharmaceutical businesses in this important region.
\n","image":false,"zone":"asia_pacific","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Espagne","name":"Gattefossé España ","event_link":"https://www.gattefosse.com/fr/corporate-events/events/","position":{"address":"","lat":"40.431099512795356","lng":"-3.671826124191284"},"production_site":"Gattefossé España S.A.","address":"C/Padilla, 73, 1°BThe Gattefossé Mediterranean affiliate is led by Mr Fayçal El Aouni and has its regional hub in Tunis. This affiliate allows the group to consolidate its presence in North Africa and the Middle East by marketing its products to customers directly as well as offering technical support and expertise to local distributors. With this regional organisation, Gattefossé is strengthening its presence among pharmaceutical and cosmetics companies in these countries by offering them the benefit of its formulation expertise.
\n","image":false,"zone":"africa_middle_east","website":""},{"section":["personal_care","pharmaceuticals"],"type":"affiliate","country":"Royaume-Uni","name":"Gattefossé U.K","event_link":"https://www.gattefosse.com/fr/corporate-events/events/","position":{"address":"","lat":"51.40541690942689","lng":"-0.6773972511291504"},"production_site":"Gattefossé U.K. Ltd","address":"4 Queens SquareGattefossé UK was established in 2001 to service Personal Care and Pharmaceuticals industries in the United Kingdom and Ireland. Since its creation, this unit has enjoyed a permanent growth and has demonstrated key competencies to growing the presence of Gattefossé as provider of innovative solutions involving its performance ingredients. Our specialized team of professionals (marketing and technical support, customer service) is fully committed to servicing our customers from our Corporate Office in Berkshire. Gattefossé UK also distributes Personal care ingredients from Lessonia and Mitsubishi.
\n","image":false,"zone":"europe","website":""},{"section":["personal_care","pharmaceuticals","application_laboratory"],"type":"affiliate","country":"Etats-Unis","name":"Gattefossé USA","event_link":"https://www.gattefosse.com/fr/corporate-events/events/","position":{"address":"","lat":"40.934459736905126","lng":"-74.07849311828613"},"production_site":"Gattefossé USA Corporation","address":"Plaza I, 115 West Century RoadThe USA and Canadian affiliates of Gattefossé (created respectively in 1982 and 1997) were established to provide local service and support to the.pharmaceutical and personal care industries in North America. Since its creation, Gattefossé North America has enjoyed continuous growth, expanding its presence as a provider of innovative solutions involving performance ingredients. Under the leadership of Eric Brun, Ph. D, a specialized team of professionals, including marketing, customer service, supply chain, quality, and technical support, is fully committed to servicing customers from the corporate offices in Paramus, NJ, Toronto, ON and Montreal, QC. Local service is also provided by long-term partners in the US Midwest and West Coast, as well as Mexico. Today, Gattefossé has 34 employees and 3 offices in North America as well as 3 warehouses in Edison (NJ), La Mirada (CA) and Toronto (Canada).
\n","image":false,"zone":"america","website":""},{"section":["personal_care","pharmaceuticals"],"type":"distributor","country":"Egypte","name":"S.G.D.","event_link":"https://www.gattefosse.com/fr/pharmaceuticals-content/enhancing-oral-bioavailability-of-cbd-formulation-with-surfactant/","position":{"address":"","lat":"30.05029940350868","lng":"31.200098991394043"},"production_site":"S.G.D.","address":"8 Kasr El Nil Street - P.O. Box 1379Get ideas from our lab. Discover our best formulas featuring our actives and textures.
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En ce début des années 1980, Gattefossé décide de mettre un coup d’accélérateur à son développement international. Jacques Moyrand va en devenir la cheville ouvrière. La nouvelle stratégie se caractérise par une implantation directe dans les pays où les perspectives de croissance sont importantes. Entre 1979 et 1989, Gattefossé ouvre ainsi des filiales en Suisse, aux États-Unis, en Espagne, en Allemagne et en Italie. Ailleurs, l’entreprise continue de s’appuyer sur des distributeurs pour vendre ses produits.
\nCette filialisation engendre de facto l’émergence d’un groupe. En 1994, Gattefossé se structure officiellement comme tel après avoir, l’année précédente, donné naissance à Gattefossé France, une filiale exclusivement dédiée au développement commercial sur le territoire français. À l’initiative de son directeur, François Wagmann, Gattefossé France lance la revue AddiActive, qui s’adresse, dans l’univers de la cosmétique, autant aux formulateurs qu’aux équipes marketing et qui présente des informations scientifiques, des tendances dans le domaine de la beauté et des exemples de formulations utilisant les actifs et ingrédients Gattefossé, le tout avec un ton léger et humoristique qui deviendra au fil du temps sa marque de fabrique.
\nAfin de se rapprocher davantage de ses clients, l’entreprise s’organise en deux divisions, correspondant à ses deux marchés : cosmétique et pharmacie. En parallèle, elle favorise l’émergence d’une dimension marketing forte au sein de sa stratégie de développement : c’est ainsi que naissent les premières structurations de gammes et de “segmentation de l’offre”, par applications (orale, topique, rectale…) ou par propriétés applicatives (émulsifiants, actifs, solubilisants…), et non plus par définitions chimiques comme c’était le cas préalablement.
\nDu côté de la production, Bernard Perrot fait progresser l’organisation de l’outil industriel de Saint-Priest pour en faire une unité adaptée aux exigences et aux normes qui se multiplient. Amélioration des process, intégration des référentiels et normes de qualité certifiant sa production, lisibilité des comptes activité par activité, solide prise en main de la distribution partout dans le monde… tout est en place pour que le groupe poursuive son expansion.
\nEn 1992, Gattefossé élabore avec le Professeur Pourrat, de l’Université de Clermont-Ferrand, un procédé d’extraction issu de la technologie des hyperfréquences qui conserve les caractéristiques naturelles des plantes fraîches. Baptisé Gatuline® R – pour régénérant –, l’actif issu de l’extraction de bourgeons de hêtre (photo ci-contre) deviendra un produit emblématique de l’entreprise et renforcera sa position dans la phytocosmétique. La gamme Gatuline® s’enrichira au cours des années suivantes d’une dizaine de références supplémentaires.
\nLa création de la Gatuline® R marque l’achèvement d’une mutation décisive pour l’entreprise : Gattefossé s’éloigne définitivement des actifs d’origine humaine (extraits placentaires) et bovins (collagène) pour aller vers une offre renouvelable et objectivée, exclusivement issue du végétal. Cette transformation va mobiliser l’ensemble du groupe pendant de nombreuses années : la R&D bien entendu, mais aussi la production, le marketing et les ventes.
\nAutre évolution importante en cosmétique : “l’expertise de la sensorialité”. C’est en 1996 que Gattefossé se lance dans le défrichement de ce nouveau savoir en créant un panel sensoriel, groupe d’une quinzaine de collaborateurs entraînés régulièrement et spécialisés dans la mesure et l’étalonnage de l’aspect, de l’odeur et du toucher des formulations cosmétiques, des propriétés déterminantes pour le consommateur. Cette expertise deviendra au fil des années un atout différenciant important pour l’entreprise.
\nDu côté de la pharmacie, ces années 1990 sont marquées par la création des SMEDDS (Self Microemulsifying Drug Delivery System), qui font l’objet d’un brevet en 1995. Avec les SMEDDS, Gattefossé amorce une longue période au cours de laquelle elle devra convaincre l’industrie pharmaceutique de l’utilité des systèmes lipidiques et de leurs propriétés favorisant l’absorption des principes actifs peu solubles dans l’organisme. Elle va désormais porter ses efforts non plus sur la création de nouveaux excipients, mais sur les technologies de formulation et de drug delivery.
\nEn désaccord avec la famille Gattefossé sur l’organisation et le management de l’entreprise, Bernard Perrot se retire en 1996. Il est remplacé par Jacques Moyrand.
\n\n
Au cours de la décennie 2010, de nouvelles filiales voient le jour : Gattefossé do Brasil en 2012, Gattefossé Asia Pacific à Singapour en 2014, et Gattefossé Méditerranée (installée à Tunis) en 2016.
\nAfin de répondre à des problématiques de sécurisation de sa production, Gattefossé se rapproche en 2009 du groupe industriel piémontais Faci, afin de disposer d’un atelier de production oléochimique sur le site de cette entreprise à Singapour. En 2013, cette unité est en mesure de livrer ses premières commandes. C’est un événement important dans la mesure où c’est la première fois que Gattefossé se lance dans l’aventure de la production à l’étranger. Elle y est fortement poussée par ses clients qui souhaitent que les fabrications de l’entreprise ne soient pas concentrées sur un seul site. En 2018, une nouvelle étape est franchie avec la décision d’implanter un nouvel équipement industriel au Texas (États-Unis).
\nCe déploiement à l’international est piloté par Olivier Midler, Directeur Marketing & Business Development, qui prend en 2011 la direction générale du groupe, Jacques Moyrand en assurant toujours la présidence. Lors de son départ à la retraite en 2018, Olivier Midler sera remplacé par Eduardo de Purgly.
\nEn France, le début des années 2010 est caractérisé par des investissements industriels importants sur le site de Saint-Priest, qui permettent de doter l’entreprise de moyens et d’outils de recherche très performants. Inauguré en 2011, le Pôle technologique Blanche Gattefossé (photo ci-dessous) rassemble les laboratoires d’applications des activités cosmétiques et pharmaceutiques et accueille un laboratoire de biologie cellulaire. Ce dernier permet à l’entreprise d’identifier les propriétés intéressantes des extraits de plantes qu’elle développe, de réaliser l’évaluation in vitro et ex vivo de ses actifs cosmétiques et d’orienter les études cliniques d’objectivation, réalisées par des sociétés extérieures.
\nSur le plan commercial, on voit, au cours de la décennie 2010, monter en puissance les excipients pharmaceutiques pour la voie orale – le Labrasol® et le Compritol® obtiennent de beaux succès. En 2013, les ventes d’excipients pour cette voie d’administration dépassent pour la première fois le chiffre réalisé par les excipients pour suppositoires.
En 2017, vingt ans après l’arrivée de Jacques Moyrand à la présidence de l’entreprise, le chiffre d’affaires de Gattefossé dépasse la barre des 100 millions d’euros. Près de 70 % des ventes sont réalisées en dehors du territoire national ; elles sont également réparties entre les domaines de la pharmacie et de la cosmétique.
\nAttachée à son indépendance financière et à ses valeurs dans un secteur où dominent les grands groupes, l’entreprise familiale doit désormais s’organiser pour faire face à l’augmentation des commandes et à l’intensification des contraintes réglementaires, afin d’accroître son niveau d’expertise scientifique, d’affronter la tendance protectionniste qui gagne l’ensemble des pays du monde, et pour prendre en considération dans ses actions au quotidien les enjeux sociétaux et environnementaux qui sont les siens.
\nForte de ses marques – Tefose®, Labrafil®, Transcutol®, Gatuline®, Emulium® et bien d’autres – qui sont de puissantes ambassadrices auprès de ses clients, forte des travaux engagés par ses chercheurs et de la performance de ses outils d’applications, Gattefossé poursuit une stratégie résolument tournée vers le long terme. Désormais dotée de moyens de production hors de ses frontières et d’équipes installées sur tous les continents, l’entreprise continue son développement pour accompagner, avec passion et conviction, les progrès des deux industries, pharmaceutique et cosmétique, qu’elle n’a cessé de servir depuis sa création.
\n\n
A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms.
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on lipid-based formulations"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":37,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Publications on lipid-based formulations | Gattefossé","_yoast_wpseo_metadesc":"Find out Gattefossé publications on lipid-based formulations."},"categories":[36],"tags":[],"acf":{"component":"PageSpecialContentPharma","title":"Publications on lipid-based formulations","introduction":"List of Gattefossé publications on lipid-based formulations.","":false,"content":[{"wysiwyg":"Jasmine Musakhanian, Jean-David Rodier and Masumi Dave
\nGattefossé
\nKetkee Deshmukh, Agnivesh Shrivastava, Sunil Bambarkar
\nPharma Times – Vol. 53 – No. 12, December 2021
\n\n\n"},{"wysiwyg":"
AGNIVESH SHRIVASTAVA , KETKEE DESHMUKH, RENUKA TIWARI, SUNIL BAMBARKAR, NABIL FARAH,
\n KAVITA SINGH
AAPS 2021
\nIn this study, Gelucire® 44/14 in type IV lipid-based formulation has been evaluated to increase the solubility and in vivo performance of ticagrelor.
\n\n"},{"wysiwyg":"American Pharmaceutical Review, February 2021
\nCamille Dumont, Cécile Morin
\n\nIntroduction
\nChapter I : Lipids, reliable partners to enhance oral bioavailability of poorly water-soluble drugs
\nChapter II : Lipids to enhance the intestinal permeability of poorly permeable drugs
\n
Chapter III : Targeting lymphatic absorption with appropriate lipid excipients selection
\nChapter IV : Mitigating food effect with lipid-based formulations
\nChapter V : Gattefossé range of functional excipients
\n for oral bioavailability enhancement
\n
Inayet Ellis
\nTablets & Capsules, April 2020
\n\n"},{"wysiwyg":"Ben J. Boyd, Christel A.S. Bergström, Zahari Vinarov, Martin Kuentz, Joachim Brouwers, Patrick Augustijns, Martin Brandl, Andreas Bernkop-Schnürch, Neha Shrestha, Véronique Préat, Anette Müllertz, Annette Bauer-Brandl, Vincent Jannin
\nEuropean Journal of Pharmaceutical Sciences, Volume 137, 2019, 104967,
\n ISSN 0928-0987, https://doi.org/10.1016/j.ejps.2019.104967.
In this excellent review article issued from the UNGAP program (European Network on Understanding Gastro-intestinal Absorption-related Process) you will find relevant and up-to-date information on:
\n[Bioavailability enhancement of active pharmaceutical ingredients through formulation strategies]
\nE Levacher, C Buffangeix, MJ Celadon, I Decorte, P Gestin, J Hecq, F Jego, B Paillard, A Plantefeve, X Thomas
\nThe SFSTP commission on Bioavailability published an article reviewing the formulation strategies to enhance the bioavailability of APIs.
\nInterestingly this article is both in French and English languages.
\n\nI Introduction
\nII Prerequisites
\n1 Initial identification and characterization of the active ingredient
\n 1.1 Physico-chemical characteristics
\n 1.2 Impact of physicochemical characteristics on absorption
\n 1.3 Passive diffusion prediction tools
\n 1.4 In silico prediction
\n 2 Biopharmaceutical classifications
III Formulation strategies
\n1 prerequisites
\n 2 techniques for increasing the dissolution rate
\n 3 Solubility enhancement technologies
\n 4 Improving the permeability, oral route
IV Control, assessment, prediction of the bioavailability
\n1 Physicochemical control methods for the manufacturing intermediates and finished products
\n 2 Assessing an dpredicting the bioavailability of the formulations
V Alternative strategy: changing the route of administration
\nVI Conclusion: decision tree
\nPharma Times September 2019 – Special issue
\n\nLipid excipients in pharmaceutical technologies
\n Nabil FARAH and Joel DENIS
Lipidic excipients in drug delivery for solubility and bioavailability enhancement
\n Prashantkumar K. PARMAR, Srilaxmi G. RAO, Arvind KK. BANSAL
From exploration of lipids to its exploitation in market: Pharmaceuticals, Nutraceuticals and Herbal
\n Saurabh ARORA, Abhinav GARG, Karishma KAPOOR
A snapshot of lipid excipients for topical formulations
\n Renuka TIWARI, Ketkee DESHMUKH, Agnivesh SHRIVASTAVA, Kanchan KOHLI
Strategic lipid-based delivery interventions for enhancing oral bioavailability of BCS II/IV drugs
\n Teenu SHARMA, Ranjot KAUR, Sumant SAINI, Atul JAIN, Bhupinder SINGH
Unleashing role of excipients in overcoming formulation challenges
\n Meenakshi VENKATARAMAN, Megha MARWAH, Mangal NAGARSENKER
Role of lipid excipients in oral sustained release drug delivery systems
\n Divya JAIN, Namita DESAI
Ketkee DESHMUKH, Agnivesh SHRIVASTAVA, Sunil BAMBARKAR, Nabil FARAH, Kavita SINGH
\nIn this case study using curcuminoids as model drug, the authors show that in vitro lipolysis test is a useful tool to predict in vivo performance
\nPoster CRS 2019
\n\n"},{"wysiwyg":"Kapilkumar Vithani, Vincent Jannin, Colin W. Pouton, Ben J. Boyd
\nIn this review article, the authors explain the importance of the colloidal structures formed during dispersion and digestion of self emulsifying lipid-based formulations on drug solubilization and absorption.
\nA review of the techniques used to characterize the colloidal structures is also carried out.
\n\n"},{"wysiwyg":"Dr. Jason LePree Drug Development & Delivery, Issue: October 2017, Posted Date: 9/29/2017 This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome impediments to good bioavailability of therapeutic actives, including poor water solubility, low permeability, and degradation by stomach acid or enzymes in vivo.
\n\n"},{"wysiwyg":"September 2015 This white paper describes the important milestones achieved in lipid based formulation (LBF) development for oral drug delivery. Collaborative research between academic and industrial partners has increased understanding of the functional properties of lipid excipients and the role they play in solubilizing poorly water soluble compounds. It has also led to the development of in vitro – in vivo predictive analytical tools. The key scientific articles describing these milestones are collected in this one White Paper, providing a single source of practical information for those interested in lipid formulation development.
\n\n"},{"wysiwyg":"Vincent Jannin, Stéphanie Chevrier, Matthieu Michenaud, Camille Dumont, Silvia Belotti, Yann Chavant, Fédéric Demarne.
\nThis acticle describes the work undertaken in Gattefossé R&D labs (St Priest) to develop lipid formulations for low to medium lipophilicity API: piroxicam, nifedipine and curcurmin and evaluate the effect of in-vitro digestion on the solubilizing capacity of the formulations.
\n\n"},{"wysiwyg":"Vincent Jannin, Camille Dumont, Hamza Benhaddou, Stéphanie Chevrier, Yann Chavant, Christophe Voutsinas, Frédéric Demarne
\nAAPS 2014
\n\n"}],"content_not_translated":true,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/26578"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/37"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=26578"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/26578/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=26578"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=26578"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=26578"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"sustainable-cosmetics-rspo":{"id":3930,"date":"2017-05-04T10:22:17","date_gmt":"2017-05-04T10:22:17","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=3930"},"modified":"2017-05-31T14:14:33","modified_gmt":"2017-05-31T14:14:33","slug":"sustainable-cosmetics-rspo","status":"publish","type":"page","link":"https://www.gattefosse.com/personal-care-special-content/sustainable-cosmetics-rspo/","title":{"rendered":"Sustainable Cosmetics & RSPO"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":""},"categories":[35],"tags":[],"acf":{"component":"PageSpecialContentPersonalCare","title":"Sustainable Cosmetics & RSPO","introduction":"Use of palm oil has deeply affected the biodiversity of Southeast Asia – contributing to deforestation and animal endangerment. To counter such damaging effects on the environment, a Roundtable on Sustainable Palm Oil (RSPO) was established in 2004. RSPO certification of palm oil is the promise that plantations involved offer a true guarantee of traceability along with improved working conditions.\n
\n"},{"wysiwyg":"
\n
Palm oil dominates the worldwide oil market. It is used in food, energy, industrial uses, and of course, personal care. Yet its impact on deforestation and biodiversity have rightfully raised concerns – primary forest in Indonesia, the main producer of palm oil, is rapidly being eroded.
The rapid and unplanned culture of oil palm has deeply affected the biodiversity of Southeast Asia. As demand for palm oil has grown, deforestation and endangerment of local animal species has become a growing problem.
\n\n
\n"},{"wysiwyg":"
\n
To combat these environmental concerns, the Roundtable for Sustainable Palm Oil (RSPO) was created in 2004 with a goal of making sustainable cultivation of palm oil, respectful of people and the environment, the norm instead of the exception. RSPO certified sustainable palm oil has been produced to stringent environmental and social criteria.
\n\n\n
1 – Book & Claim – Certified palm producers register output with GreenPalm and are granted certificates for each ton of sustainable palm oil produced. Manufacturers bid for those certificates, thereby supporting the production of sustainable palm oil.
\n2 – Mass Balance (MB) – Allows for a mixture of sustainable and conventional palm oil. Overall volumes of each are carefully monitored
\n3 – Segregated SG – Allows for certified palm oil to come from a number of producers, but guarantees that the entire quantity of palm oil is sustainably produced.
\n4 – Identity Preserved – Requires that the supply be directly traceable. All steps in the supply chain are documented, creating a paper trail that can be followed back all the way from end-users to one specific palm grower.
\nLearn more about the pillars of RSPO and levels of certification here or at www.rspo.org.
\n"}]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/3930"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=3930"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/3930/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=3930"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=3930"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=3930"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"labrafac-lipophile-wl-1349":{"id":3231,"date":"2017-04-26T09:46:56","date_gmt":"2017-04-26T09:46:56","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=3231"},"modified":"2021-12-16T11:58:57","modified_gmt":"2021-12-16T09:58:57","slug":"labrafac-lipophile-wl-1349","status":"publish","type":"page","link":"https://www.gattefosse.com/pharmaceuticals-products/labrafac-lipophile-wl-1349/","title":{"rendered":"Labrafac™ lipophile WL 1349"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":""},"categories":[7],"tags":[],"acf":{"component":"PageProductPharma","":false,"product_codes":[{"code":"3139"}],"product_image":{"id":13616,"alt":"","title":"liquid","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1.jpg","width":1716,"height":600,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-300x105.jpg","medium-width":300,"medium-height":105,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-768x269.jpg","medium_large-width":474,"medium_large-height":166,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-1024x358.jpg","large-width":474,"large-height":166,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/liquid-1-1038x576.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":576}},"product_title":"Labrafac™ lipophile WL 1349","introduction":"An oily vehicle and solubilizer of lipophilic APIs for oral and topical lipid-based formulations (LBFs).
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\n\n
“In this area, every little bit counts”
\n\n
\n
All new personal care ingredients are developed according to sustainable sourcing criteria. We are committed to respecting human rights, labor standards, environment, biodiversity throughout the value chain of our products, as well as business ethics by our Responsible Procurement Policy.
\n\n
Our current priorities are to:
\n\n
\n
\n
\n
\n To go further:
\n\n
Each year, we carry out a carbon assessment in order to take into account global warming issues in our strategy and to reduce our carbon footprint.
\n\n
Our current priorities are to:
\n\n
\n
\n
\n
\n
The eye contour is fragile and constantly in movement. This favors the formation of under-eye, tear trough, and crow’s feet wrinkles, which create facial expressions projecting sadness, fatigue, bitterness, and sternness. Reconnecting the epidermis to the dermis, Gatuline® Link n Lift acts on all eye contour wrinkles for a younger and fresher look: the face regains a rested, positive expression.
\n","use_level":"2%","naturalite":"ECOCERT / COSMOS certifiedGatuline® Link n Lift is the first active derived from the horse chestnut flower, rich in active molecules (i.e., flavonoids, tannins, amino acids, and sugars). It is obtained using Natural Deep Eutectic Solvents (NaDES) technology.
\nNaDES yields active compositions unattainable with conventional solvents. Natural, nontoxic, and effective at low temperatures, NaDES is perfectly aligned with Gattefossé’s strategy to provide high-performance sustainable ingredients. The horse chestnut flowers are handpicked in Ardèche, France, for responsible sourcing.
\n\n","":false,"origin_video":"","key_benefits_carousel":[{"content":"As demonstrated in vitro on skin cells
\nAt a use level of 2%, Gatuline® Link n Lift visibly acts on all eye contour wrinkles—crow’s-feet, undereye wrinkles, and tear trough wrinkles. A double- blind study with a placebo control has confirmed this eye contour rejuvenation: the first effects are apparent in just two weeks. Wrinkles are visibly reduced, and the skin is toned and smoothed.
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The miscibility and dispersability test is part of the Lipid-Based Formulation development.
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\n","link":"https://www.gattefosse.com/pharmaceuticals-content/topical-delivery-cannabinoids"},{"image":{"id":19826,"alt":"","title":"Cannabinoid solutions","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/3.jpg","width":125,"height":145,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/3.jpg","thumbnail-width":125,"thumbnail-height":145,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/3.jpg","medium-width":125,"medium-height":145,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/3.jpg","medium_large-width":125,"medium_large-height":145,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/3.jpg","large-width":125,"large-height":145,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/3.jpg","post-thumbnail-width":125,"post-thumbnail-height":145,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/05/3.jpg","twentyfourteen-full-width-width":125,"twentyfourteen-full-width-height":145}},"title":"Medicinal cannabinoids","text":"Stay tuned to our webpage and get tips to formulate cannabinoids with our lipid excipients
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\nIn this literature review you will find a selection of the most relevant articles about Maisine® (Glyceryl monolinoleate) as an oily vehicle for Lipid-Based Formulations (LBF)
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\n","link":"https://www.gattefosse.com/back/files/CS%20202005%20How%20to%20select%20the%20best%20permeation%20enhancer%20for%20benzoylaconitine%20transdermal%20patch.pdf"},{"image":{"id":18569,"alt":"Gattefosse Live Online Seminar Program","title":"Gattefosse Live Online Seminar Program","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2016/11/750x800px.jpg","width":2083,"height":2222,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2016/11/750x800px-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2016/11/750x800px-281x300.jpg","medium-width":281,"medium-height":300,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2016/11/750x800px-768x819.jpg","medium_large-width":474,"medium_large-height":505,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2016/11/750x800px-960x1024.jpg","large-width":474,"large-height":506,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2016/11/750x800px-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2016/11/750x800px-1038x576.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":576}},"title":"Live Online Seminar Program","text":"Gattefossé organizes a series of webinars.
\nTopics, dates and registration links available here!
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\nDiscover its full potential in our dedicated brochure.
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\nSolubilisation behaviour of poorly water-soluble drugs during digestion of solid SMEDDS
\nLipid-based nanosuspensions for oral delivery of peptides, a critical review
\nSelf-emulsifying peptide drug delivery systems: How to make them highly mucus permeating
\nCompritol® 888 ATO: a sustained release lipid matrix for once a day aceclofenac tablets
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Interest of carriers for the development of solid self-emulsifying drug delivery systems
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\nSolubilisation behaviour of poorly water-soluble drugs during digestion of solid SMEDDS
\nLipid-based nanosuspensions for oral delivery of peptides, a critical review
\nSelf-emulsifying peptide drug delivery systems: How to make them highly mucus permeating
\nCompritol® 888 ATO: a sustained release lipid matrix for once a day aceclofenac tablets
\nInterest of carriers for the development of solid self-emulsifying drug delivery systems
\nBibliography on Gattefossé’s products. 2004-2005 review.
\nDevelopment of immediate release pellets of poorly soluble compounds using Gelucire® 44/14
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\nSensory profile:
\nProperties:
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\nDay after day, skin and hair face stress, pollution, UV, and other harsh elements. This constant assault leads to dryness, dullness, and loss of radiance. Additionally, the damage to skin cells can lead to a loss of energy and efficiency. An effective way to restore radiance and energy is to bring more oxygen to cells and thereby boost their metabolism. By increasing their energetic potential, Phylderm® Vegetal stimulates cell renewal, amplifying skin radiance and making hair more resistant to environmental damage.
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\nDiscover Dermasol and learn how to formulate topical dosage forms for efficient skin penetration.
\n
\n
\n
Three main steps govern drug diffusion from the formulation to the skin:
\nDiscover Gattefossé range of excipients for skin penetration
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\nPoster ADRITELF / APGI 2018
\n\n"},{"wysiwyg":"KapilkumarVithani, Alvaro Goyanes, Vincent Jannin, Simon Gaisford, Ben Boyd
\nCRS 2018 poster
\n\n\n"},{"wysiwyg":"
Kapilkumar Vithani, Adrian Hawley, Vincent Jannin, Colin Pouton, Ben J. Boyd
\nEuropean Journal of Pharmaceutics and Biopharmaceutics, Volume 130, September 2018, Pages 236-246
\n\nKapilkumar Vithani, Adrian Hawley, Vincent Jannin, Colin Pouton, Ben J. Boyd
\nThe objective of this study is to evaluate how solid self-microemulsifying drug delivery systems (SMEDDS) behave during digestion. SMEDDS containing Gelucire® 44/14 and surfactants were prepared and their dispersion and digestion behaviors were studied using an in vitro lipolysis model, coupled with small-angle X-ray scattering (SAXS) to determine the formed colloidal structures during digestion in real time.
\n
The study shows that the lipid to surfactant ratio has a significant effect on the kinetics of digestion and an optimum ratio is prerequisite to develop rapidly digestible solid SMEDDS system.
\n\nKapilkumar Vithani, Vincent Jannin, Colin Pouton, Ben J. Boyd
\nPoster AAPS 2016
\n\n"},{"wysiwyg":"Vincent Jannin; Stéphanie Chevrier; Cédric Miolane; Margaux Metin; Hamza Benhaddou; Yann Chavant; Fred Monsuur; Frédéric Demarne
\nAAPS 2016
\n\n"},{"wysiwyg":"CHAMBIN Odile, JANNIN Vincent, CLERC Sophie, POURCELOT Yvette
\nPoster PBP 2006
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\nNature is a constant inspiration for cosmetics ingredients, but plants are not the only sources of natural actives. Mineral Matters™ liquid stone extracts apply special technology to extract important minerals from precious stones and make them bioavailable to the skin. The result is a unique line of substantiated stone actives that enhance and protect. Hema’Tite is an iron-rich active extracted from hematite. This novel antiaging active stimulates collagen synthesis and increases the thickness of the epidermis with a retinol-like action: wrinkles are erased and skin is visibly firmer and thicker. See the other actives in this Mineral Matters™ line:
\nThe stones used to create Hema’Tite liquid stone extract are sourced in Brazil. A specific iron complex is then extracted from the stones to yield an active for skin application.
\nIn vitro, ex vivo, and in vivo tests prove Hema’Tite™ effectively
\n Gattefossé a établi des liens étroits avec la communauté scientifique internationale et partage ses connaissances par le biais de publications, de séminaires et de conférences.
L’entreprise soutient des doctorants et gère des projets de recherche sous contrat avec divers groupes universitaires dans le monde.
\n\n
A nonionic oil-in-water emulsifier for topical emulsions. It provides excellent emulsion stability with difficult-to-formulate and combination APIs. Provides heat stability and high tolerance over a wide pH range.
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Developing new plant-based actives is one of the main missions of Gattefossé’s scientific team."},"categories":[56],"tags":[],"acf":{"component":"PageGenericContentCos","title":"A history of plants","content":"Botany is a constant source of inspiration. The diversity of plants around the world, their properties, their unique composition and their benefits to health and beauty make them a fascinating fieldwork for scientists.
\nDeveloping new plant-based actives is one of the main missions of Gattefossé’s scientific team.
\n\n
\n
\n
It all starts with René Maurice Gattefossé, back in the 1910s. He spent many years working on lavender fields, in Provence (France), helping the farmers to improve cultivation and distillation methods and creating the first lavender growers’ cooperative.
\nLater, he purchased a farm in Saint-Rémy-de-Provence, thus creating an aromatic plant production and distillation center, providing his company with raw materials.
\n\n
\n
\n
\n
Gattefossé scientists have a strong knowledge in botany but also in phytochemistry, physiology and ecology. This allows them to select the best raw materials.
\nThe first step consists in identifying the plants of interest for a specific cosmetic application. This complex process – where chemistry, taxonomy and knowledge of customers’ requirements intersect – leads to the discovery of new botanical materials.
\nThe activity of the plant extracts that caught our attention is then evaluated in preliminary research to validate their action on specific biological targets and to ideally identifythe exact molecules responsible for this activity.
\nOnce the plant identified and validated, our team select the best sourcing, based on geographical origin, cultivation and harvesting methods, respect of the environment, shipment conditions, etc.
\nFrom planting stage to harvest and shipment, all steps are controlled to ensure a responsible and sustainable supply chain, strictly following all regulations concerning access to biodiversity, fair trade and environment. Our set of specifications is clearly defined and applies for all our partners.
\n\n
\n
Green chemistry is at the heart of our processes. Depending on the plant we are working on and the results that are expected, different methods and solvents can be used to extract the active fraction in the plants:
\nEach process is optimized to guarantee a constant content of active molecules in each batch produced.
\nGattefossé has also developed a wide range of separation, purification, soaking and concentration techniques that uses ultrafiltration, distillation or chromatography.
\nAll these techniques, combined with Gattefossé’s knowledge and expertise, allow us to provide the market with high-quality ingredients.
\n\n
Hard fat suppository base with high crystallization rate. Confers high mechanical resistance and yields harder suppository units.
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\n","link":"https://www.gattefosse.com/back/files/01%20Gattefosse%20Panorama%20Newsletter%20April%202016%20Pediatric%20Medicines.pdf"}]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/9523"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=9523"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/9523/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=9523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=9523"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=9523"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"inflammaging":{"id":24666,"date":"2021-07-16T22:13:26","date_gmt":"2021-07-16T20:13:26","guid":{"rendered":"https://www.gattefosse.com/?page_id=24666"},"modified":"2021-07-21T15:36:34","modified_gmt":"2021-07-21T13:36:34","slug":"inflammaging","status":"publish","type":"page","link":"https://www.gattefosse.com/personal-care-trend/inflammaging/","title":{"rendered":"Inflammaging – The silent killer"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":17,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Inflamm'aging: The Silent Killer","_yoast_wpseo_metadesc":"Discover Gattefossé's active that resolves inflammation and soothes sensitive skin!"},"categories":[56],"tags":[],"acf":{"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"main_img_article":{"id":24673,"alt":"","title":"Inflammaging","caption":"","description":"","mime_type":"image/png","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/07/Inflammaging.png","width":1536,"height":510,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/07/Inflammaging-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/07/Inflammaging-300x100.png","medium-width":300,"medium-height":100,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/07/Inflammaging-768x255.png","medium_large-width":474,"medium_large-height":157,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/07/Inflammaging-1024x340.png","large-width":474,"large-height":157,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/07/Inflammaging-672x372.png","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2021/07/Inflammaging-1038x510.png","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":510}},"component":"PageGenericContentCos","title":"Inflamm'aging","description":"The Silent Killer","content":"Most of us are familiar with the term inflammation. It’s our body’s natural response to protect us from infections and repair damaged tissues. Inflammation is typically visualized by redness and irritation around the infection site. But did you know that there is a type of inflammation that is silent and can cause premature aging? This chronic, low-grade inflammation is called inflamm’aging and is induced by age. Typically, its effects can go undetected and can worsen or build up over time. “It is considered to be one of the driving forces behind many age-related diseases such as diabetes, atherosclerosis, age-related macular degeneration, and skin aging.”(1) This is why many refer to inflamm’aging as the “silent killer.”
\n\n
\n
To understand inflamm’aging, we need to first take a look at the inflammation process and the components that induce and terminate responses. The inflammation process is a three-step mechanism consisting of initiation, amplification, and resolution phases. Initiation is where pro-inflammatory mediators are released, and clinical signs such as redness, swelling, heat, or pain occur. During amplification, the mediators aggregate to the infection site and further aggravate those symptoms, depending on the extent of the damage. An finally, the resolution phase where a specific family of lipid mediators – specialized pro-resolving mediators (SPMs) – are used to terminate the inflammation process to allow the tissue to heal. This step is critical in avoiding chronic disorders and allows for skin homeostasis. In damaged skin or inflamm’aged skin, however, this process is deregulated. Resolution is incomplete and therefore leads to a chronic state of inflammation without any tissue repair.
\n\n
\n
In 2019, Gattefossé conducted a study, in collaboration with Ambiotis, on young and mature skin to understand the differentiation of the resolution of inflammation and deregulation of SPM synthesis. The study found that young skin presented high responsiveness toward inflammatory stress and effective restoration of skin homeostasis due to the efficient synthesis of SPMs. Whereas, mature skin showed a weaker responsiveness toward inflammatory stress and compromised resolution mechanism characterized by reduced production of SPMs.
\n\n
\n
We determined that the best strategy to combat inflammation was to develop an active that targeted the resolution phase of the inflammation process.
\n Meet Gatuline® Skin-Repair AF. This organic certified active combats the effects of stress by promoting the resolution of inflammation in order to bring about effective tissue repair. So how do we see this in the skin? We conducted an in vitro study on young and mature skin biopsies by subjecting them to three conditions; untreated without stress, untreated with PMA-induced stress, and treatment of 2% Gatuline Skin-Repair AF with PMA-induced stress. The results showed that in young skin, there was a significant increase in the synthesis of two lipoxins – lipoxin A4 (LXA4) and lipoxin B4 (LXB4) – that are SPM precursors. This allows for the resolution of inflammation and the prevention of chronic inflammation associated with age (inflamm’aging). In mature skin, there was a moderate increase in lipoxin synthesis, allowing the skin to cope with the vicious effects of the inflammation cycle.
\n
\n
Gauline® Skin-Repair AF is the solution to combating inflamm’aging. It works to break the vicious cycle of chronic inflammation by targeting and promoting the resolution of inflammation, thus allowing the skin to heal properly.
\n\n\n
\n
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Webinars/Events Privacy Policy
\nGATTEFOSSE SAS
\n36 chemin de Genas
\nCS70070
\n69804 Saint-Priest Cedex
\nFrance
\nWe may collect your:
\nInformation regarding your registration and participation in the Webinar/Event (log, IP address, timestamp information)
\nYou are entitled to exercise all rights mentioned in 7 below, including the right to oppose such processing. You may oppose to such processing at any time by clicking on an “unsubscribe” link in the email or by contacting us at the following email address: dataprotection@gattefosse.com.
\nThe editor of the webinar/event software may have access to your personal data to provide their services in relation to the Webinar/Event.
\nData which is processed for marketing communications purpose may be transferred to other GATTEFOSSE group companies, GATTEFOSSE’s distributors and, where the Webinar/Event is organized jointly with GATTEFOSSE’s partner(s), to such partner(s). In such case, the partner(s) will also act as a data controller(s) and the partner’s(s’) privacy policy shall govern the processing of your personal data for the partner’s(s’) purposes.
\nGATTEFOSSE group companies’ marketing platform providers may also have access to your contact details.
\nWe may transfer your personal data to GATTEFOSSE’s group companies, distributors and/or marketing platform providers outside the European Economic Area (EEA) for the above listed purposes.
\nThis may include countries that do not have the same level of protection for personal data as the EEA. In such cases, we will ensure that the privacy of your personal data is respected.
\nIf you want to receive more information regarding the international transfers of personal data, please contact us at the following email address: dataprotection@gattefosse.com.
\nYour data will be retained until we receive specific request from you in relation to the deletion of your data or until expiration of a period of thirty (30) days after the end of the Webinar/Event.
\nData which is processed for marketing communication purposes (see Section 3) will be retained until we receive specific request from you in relation to the deletion of your data.
\nYou have the right to access your data as well as the right to their rectification, erasure, restriction, or opposition of processing.
\nHowever, in relation to the Webinar/Event, the processing of certain of your personal data (first name(s), last name(s), email address) is necessary for the handling of your request. If you do not provide such personal data, we will not be able to fulfil your request.
\nFor any question you may have, as well as to exercise your rights, please contact the GATTEFOSSE at the following email address: dataprotection@gattefosse.com.
\nIn the event of an unsatisfactory response from us in exercising the rights mentioned below, you have the right to lodge a complaint with the French National Commission for Data Protection and Liberties (“CNIL”).
\n\n","content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"vignets_articles":[{"image":false,"title":"1.\tWho is responsible for the processing of personal data?","text":"
GATTEFOSSE SAS
\n36 chemin de Genas
\nCS70070
\n69804 Saint-Priest Cedex
\nFrance
\n","link":""},{"image":false,"title":"2.\tWhat personal data do we collect?","text":"We may collect your:
\nInformation regarding your registration and participation in the Webinar (log, IP address, timestamp information)
\n","link":""},{"image":false,"title":"3.\tHow do we use your personal data?","text":"You are entitled to exercise all rights mentioned in 7 below, including the right to oppose such processing. You may oppose to such processing at any time by clicking on an “unsubscribe” link in the email or by contacting us at the following email address: dataprotection@gattefosse.com.
\n","link":""},{"image":false,"title":"4.\tWill we share your personal data?","text":"LogMeIn the editor of the GoToWebinar software may have access to your personal data to provide their services in relation to the Webinar.
\nData which is processed for information purpose (please see 3.2) may be transferred to other GATTEFOSSE group companies, GATTEFOSSE’s distributors and to CATALENT Pharma Solutions. CATALENT Pharma Solutions will also act as a data controller and its privacy policy shall govern the processing of your personal data for its purposes (please consult Catalent’s privacy policy: https://www.catalent.com/privacy-policy/ ).
\nGATTEFOSSE group companies’ marketing platform providers may also have access to your contact details.
\n","link":""},{"image":false,"title":"5.\tWill your personal data be transferred to third countries? ","text":"We may transfer your personal data to GATTEFOSSE’s group companies, distributors and/or marketing platform providers outside the European Economic Area (EEA) for the above listed purposes.
\nThis may include countries that do not have the same level of protection for personal data as the EEA. In such cases, we will ensure that the privacy of your personal data is respected.
\nIf you want to receive more information regarding the international transfers of personal data, please contact us at the following email address: dataprotection@gattefosse.com.
\n","link":""},{"image":false,"title":"6.\tHow long do we keep your personal data?","text":"Your data will be retained until we receive specific request from you in relation to the deletion of your data or until expiration of a period of thirty (30) days after the end of the Webinar.
\nData which is processed for information purposes (see Section 3.2) will be retained until we receive specific request from you in relation to the deletion of your data.
\n","link":""},{"image":false,"title":"7.\tYour legal rights ","text":"You have the right to access your data as well as the right to their rectification, erasure, restriction or opposition of processing.
\nHowever, in relation to the Webinar, the processing of certain of your personal data (first name(s), last name(s), email address) is necessary for the handling of your request. If you do not provide such personal data, we will not be able to fulfil your request.
\nFor any question you may have, as well as to exercise your rights, please contact the Gattefossé at the following email address: dataprotection@gattefosse.com.
\nIn the event of an unsatisfactory response from us in exercising the rights mentioned below, you have the right to lodge a complaint with the French National Commission for Data Protection and Liberties (“CNIL”).
\n","link":""}],"useful_links":[],"box_links":[]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/23328"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=23328"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/23328/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=23328"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=23328"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=23328"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"transcutol-cg":{"id":1813,"date":"2017-04-14T08:21:33","date_gmt":"2017-04-14T08:21:33","guid":{"rendered":"/?page_id=1813"},"modified":"2019-05-03T15:47:59","modified_gmt":"2019-05-03T13:47:59","slug":"transcutol-cg","status":"publish","type":"page","link":"https://www.gattefosse.com/personal-care-textures/transcutol-cg/","title":{"rendered":"Transcutol® CG"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Transcutol® CG | Cosmetic solubilizer and efficacy booster | Gattefossé","_yoast_wpseo_metadesc":"Transcutol® CG is a superior solubilizer and efficacy booster for cosmetic formulations recognized for its exceptional safety and versatility of use."},"categories":[14],"tags":[],"acf":{"component":"PageCosmeticProduct","product_codes":[{"code":"5389"}],"bandeau_image":{"id":13837,"alt":"","title":"Transcutol CG","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/Transcutol-CG.jpg","width":1144,"height":400,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/Transcutol-CG-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/Transcutol-CG-300x105.jpg","medium-width":300,"medium-height":105,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/Transcutol-CG-768x269.jpg","medium_large-width":474,"medium_large-height":166,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/Transcutol-CG-1024x358.jpg","large-width":474,"large-height":166,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/Transcutol-CG-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/Transcutol-CG-1038x400.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":400}},"image_product_finder":{"id":2373,"alt":"Fit and confident woman in starting position ready for running. Female athlete about to start a sprint looking away. Bright sunlight from behind.","title":"Gattefossé Transcutol CG","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/transcutol-1.jpg","width":244,"height":163,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/transcutol-1-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/transcutol-1.jpg","medium-width":244,"medium-height":163,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/transcutol-1.jpg","medium_large-width":244,"medium_large-height":163,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/transcutol-1.jpg","large-width":244,"large-height":163,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/transcutol-1.jpg","post-thumbnail-width":244,"post-thumbnail-height":163,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/transcutol-1.jpg","twentyfourteen-full-width-width":244,"twentyfourteen-full-width-height":163}},"title":"Transcutol® CG","tagline":"Solubilizer & efficacy booster","description_product_finder":"","introduction":"Transcutol® CG is a powerful solubilizer and efficacy booster that has been used in the cosmetic and pharmaceutical industries for decades. The reasons for its success lie in its recognized solvent and efficacy-boosting qualities, exceptional safety, and versatility of use.
\n","use_level":"2-30%*","naturalite":"","inci":"Ethoxydiglycol","origin":"Transcutol® CG has been used in the pharmaceutical industry for over 40 years and has an excellent safety profile. *Restricted use levels in Europe:
\nEmulsionnant velours au cœur d’acier, Emulium® Delta MB a été créé pour stabiliser des formules extrêmes sans négliger la sensorialité.
\nIl confère aux émulsions formulées une incroyable stabilité. Ces émulsions présentent, une grande douceur à l’application et après absorption, s’étalent très facilement sans sensation de gras, ni de collant et pénètrent rapidement, laissant sur la peau un doux film résiduel.
\n\n","use_level":"2-6%","naturalite":"Certifié RSPO Mass Balance","inci":"Cetyl Alcohol (and)
Emulsionnant H/E, il est la réunion originale d’alcool et d’acides gras hydroxylés ligués entre eux. Insensible aux pH extrêmes (de 3 à 13) et aux actifs réputés très difficiles (AHA, DHA, H2O2, caféine…). Il est certifié RSPO Mass Balance (Roundtable on Sustainable Palm Oil).
\n","":false,"origin_video":"","key_benefits_carousel":[{"content":"Sensorialité
\nEmulium® Delta MB possède un profil sensoriel particulièrement identifiable du à son extrême douceur et toucher velours pendant et après l’application.
\n","img":{"id":4112,"alt":"sensory profile Emulium Delta","title":"delta-senso","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/delta-senso.jpg"},"video":""},{"content":"Propriétés
\n\n","img":{"id":3701,"alt":"cosmetic cream on white wooden","title":"cosmetic cream","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/delta-1.jpg"},"video":""}],"claims":"
A radiant complexion is an essential characteristic of beautiful skin. Complexion indeed plays a key role in perceptions of youth and beauty around the globe. Gatuline® Radiance enhances microcirculation, bringing blood flow to the surface layers of the skin. This in turn enhances all aspects of a radiant complexion, including skin color and luminosity. Skin brightness is visibly enhanced even under heavy pollution.
\n","use_level":"1-3%","naturalite":"","inci":"Propanediol (and)Gatuline® Radiance is obtained from Evodia rutaecarpa, also known as “Wu-Zhu-Yu”, a flowering shrub member of the Rutaceae family. Evodia rutaecarpa is widely cultivated in southeast China for Traditional Chinese Medicine. In addition to its medicinal uses, the Chinese would traditionally wear Evodia on the ninth day of the ninth Chinese lunar month (Double Ninth Festival). The plant was thought to bring luck. Preservative free.
\nIn vitro and in vivo tests prove Gatuline® Radiance effectively
\nClinically tested in heavy polluted environment, Gatuline® Radiance decreases the visibility of the redness and the dilatation of the pores.
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engagements de Gattefossé| Des ingrédients de qualité et une politique d'innovation responsable","_yoast_wpseo_metadesc":"Notre politique d'innovation nous pousse à porter une attention constante au développement de nos produits pour en minimiser l'impact sur l'environnement. "},"categories":[30],"tags":[],"acf":{"component":"PageExpertiseCorpo","title":"Engagements ","introduction":"Nous nous engageons vis-à-vis de la planète, de nos clients et de nos partenaires à réduire notre empreinte globale et à toujours encourager des rapports humains durables et éthiques, sans jamais faire aucune concession sur la qualité de nos produits. C’est par notre volonté de partager nos connaissances et de favoriser l’innovation dans nos domaines d’activité que nous entendons faire la différence.","":false,"content":[{"wysiwyg":"\n
\n
La qualité est pour nous un facteur-clé de progrès. Elle est partie intégrante de tout ce que nous entreprenons, depuis nos activités de R&D jusqu’à la commercialisation des produits.
\nNos politiques de qualité sont constamment mises à niveau afin de répondre aux attentes de nos clients et de les anticiper. Nous sommes régulièrement audités par nos principaux clients et nous nous efforçons d’améliorer de façon continue nos normes de qualité, validées par plusieurs certifications.
\n\n
\n
\n
Nous appliquons strictement les bonnes pratiques de fabrication (BPF), que ce soit pour nos excipients pharmaceutiques ou nos ingrédients cosmétiques.
\n\n
\n
Dans le cadre de notre politique de management, nous avons mis en place des mesures de sécurité strictes visant à prévenir les risques liés à nos activités – fabrication, chaîne d’approvisionnement, logistique et R&D – et nos installations – lignes de production, laboratoires d’applications et bâtiments administratifs.
\nLa formation de nos équipes fait l’objet d’une attention particulière de notre part et passe notamment par des campagnes de sensibilisation régulières. Nous définissons des indicateurs et mettons systématiquement en place des plans d’action pour assurer la sécurité de nos collaborateurs et l’innocuité de nos produits sur le long terme.
\n\n
Cet engagement en faveur de la qualité nous permet de partager des références communes avec nos clients en termes de systèmes et de normes industrielles et de les intégrer à nos propres procédures.
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\n
Pour encourager l’innovation responsable, nos processus de production ont été modernisés avec pour objectif de dépenser moins d’énergie, de réduire nos déchets et de maximiser le recyclage.
\nDepuis de nombreuses années, Gattefossé s’engage en faveur du développement durable, en réduisant sensiblement sa consommation énergétique tout en augmentant sa capacité de fabrication.
\nNotre entreprise protège l’environnement en sélectionnant avec soin des matières premières d’origine naturelle pour ses processus de production. Ainsi, Gattefossé est membre depuis 2010 de l’organisation RSPO qui soutient les coopératives et les producteurs d’huile de palme responsables. En 2017, l’entreprise a obtenu la certification RSPO « Mass Balance » pour son site de fabrication en France. Gattefossé utilise également une huile de palme certifiée « Segregated » pour sa gamme d’ingrédients cosmétiques Lipocire™.
\nGattefossé offre la garantie que ses matières premières proviennent de sources fiables, identifiables et renouvelables, grâce à un traçage rigoureux de leurs origines et des méthodes de production. Nous établissons avec nos fournisseurs des relations pérennes et les considérons comme de véritables partenaires stratégiques.
\n\n
\n
\n
Nous avons la conviction que la future croissance de notre entreprise dépend des talents qui la composent à travers le monde et qui œuvrent au quotidien pour faire de Gattefossé un acteur mondial. Le groupe est fier de sa forte culture d’entreprise, influencée par les personnalités de ses fondateurs et de ses dirigeants. Ils ont su faire évoluer la société tout en restant fidèles au code éthique établi dès sa création.
\n→ A propos de la culture d’entreprise de Gattefossé
\n"},{"wysiwyg":"\n
\n
Gattefossé a établi des liens étroits avec la communauté scientifique internationale et partage ses connaissances par le biais de publications, de séminaires et de conférences. L’entreprise soutient des doctorants et gère des projets de recherche sous contrat avec divers groupes universitaires dans le monde.
\n\n
\n
\n
\n
\n
Organisées sous l’égide de la Fondation Gattefossé, les Journées Galéniques de Saint-Rémy de Provence rassemblent chaque année la communauté scientifique internationale industrielle et académique autour d’un thème lié à la formulation des médicaments. Cet évènement vise à favoriser les échanges scientifiques en pharmacie galénique pour faire progresser les connaissances et les techniques dans ce domaine.
\nEn organisant ces rencontres, Gattefossé poursuit l’œuvre initiée dans les années 60 par Henri-Marcel Gattefossé, qui plaça l’entreprise sous le signe du dialogue avec les chercheurs du monde entier.
\nLes conclusions des Journées Galéniques sont publiées sous forme d’un Bulletin Technique* mis à la disposition de tous les professionnels du secteur pharmaceutique.
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A glyceride with a high melting point used as a modified release agent or lubricant in tablets. Can also be used in lipid coating technologies and as lipid carrier for nanoparticles.
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Chaque jour, la peau est soumise à de multiples agressions causées par le soleil, les températures trop extrêmes, la pollution. Ces agressions sont responsables d’inflammation et de dommages cutanés.
\nLa résolution de l’inflammation est une étape cruciale afin d’éviter que les désordres inflammatoires ne deviennent permanents mais elle a été négligée jusqu’ici en soin de la peau.
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\nKetkee Deshmukh, Swarnadeep Banerjee, Agnivesh Shrivastava, Sunil Bambarkar
\nThe purpose of this study is to evaluate the impact of different granulation solvents on the performance of dual extended- release matrix tablets, formulated using a combination of Compritol® 888 ATO and Methocel® K100M, with two model APIs:
\nYvonne Rosiaux, Vincent Jannin, Cécile Morin
\nWiley Library, April 2022, Editors: Edmund S. Kostewicz, Maria Vertzoni, Heather A. E. Benson, Michael S. Roberts
\n\n"},{"wysiwyg":"K. Deshmukh, A. Shrivastava, S. Banerjee, R. Tiwari, S. Bambarkar, N. Farah Gattefosse India Pvt. Ltd., Mumbai, INDIA, Gattefosse SAS, Lyon, FRANCE
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\n\n"},{"wysiwyg":"K. Deshmukh1, A. Shrivastava1, S. Banerjee1, R. Tiwari1, S. Bambarkar1, N. Farah2 1Gattefosse India Pvt. Ltd., Mumbai, INDIA, 2Gattefosse SAS, Lyon, FRANCE
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\n\n"},{"wysiwyg":"V. JANNIN, E. LECCIA, Y. ROSIAUX AND J. DOUCET
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\n\n"},{"wysiwyg":"Yvonne Rosiaux, Amandine Forrest, Jean-Michel Girard, Carole Deleglise, Delphine Marchaud
\n\n"},{"wysiwyg":"C. J. Kapadia, A. R. Shrivastava, G. R. Khanvilkar AAPS 2016
\n\n"},{"wysiwyg":"Shilpa N. PATERE, Chhanda J. KAPADIA and Mangal S. NAGARSENKER Indian J Pharm Sci 2015;77(5): 620-625 Release profile of metoprolol from sustained release tablets using Compritol 888 ATO as SR lipid matrix agent showed high reliability. Different sources of active ingredient and batches of Compritol were evaluated at different compression forces and in dissolution media containing or not ethanol. The formulation appeared to be very robust and is not affected by these variables. Therefore Compritol offers great potential in the formulation of reliable SR tablets.
\n\n"},{"wysiwyg":"Y. Rosiaux, V. Jannin, J. Doucet*, J-M. Girard, F. Desvignes, and D. Marchaud CRS 2015
\n\n"},{"wysiwyg":"Justin M. Keen, Justin R. Hughey, Ryan C. Bennett, Vincent Jannin, Yvonne Rosiaux, Delphine Marchaud, and James W. McGinity
\nWhite paper – May 2014 This white paper gives an overview of how Compritol® 888 ATO provides clinically relevant sustained drug release profiles along with biopharmaceutical, formulation and manufacturing advantages.
\n\n"},{"wysiwyg":"Yvonne Rosiaux, Vincent Jannin, Sophie Hughes, Delphine Marchaud Journal of Controlled Release Volume 188, 28 August 2014, Pages 18–30
\nThis review article focuses on the utility of lipid excipients in solid sustained drug delivery systems with emphasis on the efficiency and robustness of these systems with respect to: (i) the choice of the manufacturing process and impact on drug release, (ii) the fundamental drug release mechanisms, (iii) resistance of the drug formulation under physiological conditions and (iv) long-term stability. Understanding the functionality of these versatile excipients in formulation is elementary for the development of highly robust lipid-based sustained release medicines
\n\n"},{"wysiwyg":"AAPS 2013
\n\n"},{"wysiwyg":"Patere SN, Desai NS, Jain AS, Kadam PP, Thatte UM, Gogtay N, Kapadia CJ, Farah N, Nagarsenker MS.
\nCurr Drug Deliv. 2013 Oct;10(5):548-56.
\n\n"},{"wysiwyg":"Poster AAPS 2014
\n\n"},{"wysiwyg":"Poster CRS 2014
\n\n"},{"wysiwyg":"Poster CRS 2014
\n\n"},{"wysiwyg":"Poster CRS 2014
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\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Pharmaceutical high quality excipient supplier | Gattefossé","_yoast_wpseo_metadesc":"Gattefossé is a leading international company who has designed and manufactured functional pharmaceutical lipid excipients since 1950."},"categories":[12],"tags":[],"acf":{"introduction":"
If you are looking for high quality excipients, personalized technical support and expertise in formulating with lipids then you’re in the right place to learn more.
\nNote that the Pharmaceutical section of the website is in English only. (Notez que la section Pharmacie du site est en anglais uniquement).
\n
How to obtain sustained release tablets of metformin hydrochloride by direct compression ?
\nThe aim was to develop dual SR matrix tablets by direct compression with an equivalent drug release profile to the two doses available as market references (500 and 750 mg).
\nKeywords: dual matrix, sustained release, metformin hydrochloride, Compritol® 888 ATO, HPMC, direct compression, high drug load
\n
How to reduce drug release variability in HPMC-based sustained-release tablets ?
\nThe aim of this study was to develop a sustained-release tablet formulation using two SR agents, HPMC and Compritol® 888 ATO, in order to reduce the variations in drug release.
\nKeywords: tablet, sustained release, metformin hydrochloride, dual matrix, wet granulation process, HPMC, Compritol® 888 ATO
\n\n"},{"wysiwyg":"
How to formulate a simple emulgel with a high level of Transcutol® P
In this study, a design of experiment (DoE) was performed to assess the effects of emulsifiers and Transcutol® concentrations on emulgel appearance, pH, viscosity and stability after 24h, 1, 3, 6 and 12 months at 40°C.
\nKeywords: Emulgel, Transcutol®, Gelot™64, Emulcire® 61 WL 2659, stability, viscosity, pH
\n"}],"box_links":[{"link":"https://www.gattefosse.com/pharmaceuticals-product-finder/product-finder-pharmaceutical/","title":"Access our product finder","external_link":false,"image":"https://www.gattefosse.com/wordpress/wp-content/uploads/2016/11/tableau_noir_624x221px.jpg"},{"link":"https://www.gattefosse.com/pharmaceuticals-formulation-technologies/formulation-technologies/","title":"Understand how to use our excipients","external_link":false,"image":"https://www.gattefosse.com/wordpress/wp-content/uploads/2016/11/technologies_196x143px.jpg"}],"useful_links":[],"":false,"introduction":"Case studies are available after log-in!","vignets_articles":[{"image":{"id":19244,"alt":"","title":"NS POCC497","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/NS-POCC497.jpg","width":401,"height":257,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/NS-POCC497-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/NS-POCC497-300x192.jpg","medium-width":300,"medium-height":192,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/NS-POCC497.jpg","medium_large-width":401,"medium_large-height":257,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/NS-POCC497.jpg","large-width":401,"large-height":257,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/NS-POCC497.jpg","post-thumbnail-width":401,"post-thumbnail-height":257,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/NS-POCC497.jpg","twentyfourteen-full-width-width":401,"twentyfourteen-full-width-height":257}},"title":"How to select the best permeation enhancer for benzoylaconitine transdermal patch?","text":"Due to the high molecular weight of Benzoyl Aconitine (603.7), formulating a transdermal patch is a challenge. Among all the tested permeation enhancers, Plurol® Oleique CC 497 showed the best results.
\nKeywords: transdermal patch, Benzoyl Aconitine, Plurol® Oleique CC 497, FT-IR analysis
\n
The aim of this study was to prepare tablets by wet granulation using Gelucire® 44/14 to improve the dissolution of fenofibrate.
\nKeywords: tablet, wet granulation, fenofibrate, Gelucire® 44/14
\n","link":"https://www.gattefosse.com:443/back/files/CS 2020 04 Fenofibrate tablets with Gelucire 44_14.pdf"},{"image":{"id":17367,"alt":"","title":"Woman with Patch on Arm","caption":"Woman with Patch on Arm","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","width":106,"height":150,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674-106x150.jpg","thumbnail-width":106,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","medium-width":106,"medium-height":150,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","medium_large-width":106,"medium_large-height":150,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","large-width":106,"large-height":150,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","post-thumbnail-width":106,"post-thumbnail-height":150,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/GettyImages-77742674.jpg","twentyfourteen-full-width-width":106,"twentyfourteen-full-width-height":150}},"title":"How to formulate a daphnetin transdermal patch with enhanced permeation? ","text":"The aim of the study was to develop an optimized drug-in-adhesive patch with 1% daphnetin with good in vitro drug release and skin permeation. Backing films, permeation enhancers and permeation enhancer content were investigated through in vitro experiments.
\nKeywords: transdermal patch, daphnetin, Transcutol® P
\n
The feasibility of preparing solid SEDDS using solid (Gelucire® 48/16) and semi-solid (Gelucire® 44/14) lipid excipients with a 3D printer is assessed using two model drugs, i.e. cinnarizine and fenofibrate.
\nKeywords: 3D printing, Gelucire® 44/14, Gelucire® 48/16, fenofibrate, cinnarizine
\n","link":"https://www.gattefosse.com/back/files/CS_2019_04_Are%20lipid%20excipients%20suitable%20for%203D%20printing.pdf"},{"image":{"id":12307,"alt":"Gattefosse_oblong tablet","title":"Gattefosse_oblong tablet","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30290-e1550647845517.jpg","width":365,"height":244,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30290-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30290-300x200.jpg","medium-width":300,"medium-height":200,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30290-768x513.jpg","medium_large-width":474,"medium_large-height":317,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30290-e1550647845517.jpg","large-width":365,"large-height":244,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30290-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_30290-967x576.jpg","twentyfourteen-full-width-width":967,"twentyfourteen-full-width-height":576}},"title":"How to obtain sustained release tablets of metformin hydrochloride by direct compression ?","text":"The aim was to develop dual SR matrix tablets by direct compression with an equivalent drug release profile to the two doses available as market references (500 and 750 mg).
\nKeywords: dual matrix, sustained release, metformin hydrochloride, Compritol® 888 ATO, HPMC, direct compression, high drug load
\n
The aim of this study was to develop a sustained-release tablet formulation using two SR agents, HPMC and Compritol® 888 ATO, in order to reduce the variations in drug release.
\nKeywords: tablet, sustained release, metformin hydrochloride, dual matrix, wet granulation process, HPMC, Compritol® 888 ATO
\n","link":"https://www.gattefosse.com/back/files/How%20to%20reduce%20drug%20release%20variability%20in%20HPMC%20based%20sustained%20release%20tablets%20.pdf"},{"image":{"id":12179,"alt":"","title":"Gattefosse_27776","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776.jpg","width":2598,"height":1951,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-300x225.jpg","medium-width":300,"medium-height":225,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-768x577.jpg","medium_large-width":474,"medium_large-height":356,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-1024x769.jpg","large-width":474,"large-height":356,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2019/01/Gattefosse_27776-1038x576.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":576}},"title":"How to formulate a simple emulgel with a high level of Transcutol® P","text":"In this study, a design of experiment (DoE) was performed to assess the effects of emulsifiers and Transcutol® concentrations on emulgel appearance, pH, viscosity and stability after 24h, 1, 3, 6 and 12 months at 40°C.
\nKeywords: Emulgel, Transcutol®, Gelot™64, Emulcire® 61 WL 2659, stability, viscosity, pH
\n","link":"https://www.gattefosse.com:443/back/files/CS_201901_How to formulate an emulgel with high level of Transcutol P.pdf"}]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/12124"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=12124"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/12124/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=12124"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=12124"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=12124"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"emulsions":{"id":2928,"date":"2017-04-25T09:32:39","date_gmt":"2017-04-25T09:32:39","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=2928"},"modified":"2019-07-05T08:00:19","modified_gmt":"2019-07-05T06:00:19","slug":"emulsions","status":"publish","type":"page","link":"https://www.gattefosse.com/pharmaceuticals-products/pharmaceuticals-content/emulsions/","title":{"rendered":"Emulsions"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"How to formulate a stable emulsion | Gattefossé","_yoast_wpseo_metadesc":"Learn how to use lipid excipients to formulate stable emulsion systems and optimize the results of your formula with Gattefossé products."},"categories":[49],"tags":[],"acf":{"component":"PageGenericContentPharma","title":"Emulsions","content":"Emulsions are, by definition, unstable systems and require a surfactant. To enable simple formulation of stable emulsion system, Gattefossé offers a range of self-emulsifying bases consisting of all-in-one excipients. Due to their specific compositions combining lipophilic and hydrophilic surfactants with texture agents, they provide stable emulsions whatever the type and concentration of oil.
\nEmulsions are traditionally produced by separately preparing oily and aqueous phases and then mixing them together. Critical process parameters are temperature, blade type, mixing speed and duration, and cooling conditions. Emulsions with Gelot™ 64 are obtained in this way.
\nA one-pot process is an interesting alternative whereby all ingredients are mixed in a single step. This is achievable with a powerful emulsifier like Tefose® 63 at a minimum concentration of 12%.
\nA cold process might be necessary for heat-sensitive drugs. In such cases, the best emulsifier is Plurol® Diisostearique, which permits formulation at room temperature.
\nEmulsification is obtained when mixing and heating yield enough energy to disperse the oil droplets in the aqueous phase, or vice versa. Thus, to obtain a stable emulsion, mixing conditions need to be carefully defined during development and scale-up.
\nOur formulators have worked on scale-up—from lab- to pilot-scale production—with different formulations and equipment.
\nAsk for our Dermacare brochure
\n
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With summer in full swing in many parts of the world, consumers are looking for lighter, cooling textures to help them beat the heat. Bi-gels are a unique formulation approach that creates light and refreshing textures with numerous benefits for both skin care and sun care.
\n\n A bi-gel looks just like a standard emulsion but is actually a dispersion of an oily network within an aqueous gel. This dispersion of oil and water is then stabilized by a unique surfactant-free system – Emulfree® CBG MB. \n | \n![]() | \n
![]() | \n\n \n This unique bi-gel structure gives innovative technical and sensory properties to cosmetic formulations, different from what can be achieved with a standard emulsion. \n\n | \n
Upon application, the bi-gel breaks on the skin liberating its two phases: a fine oily layer remain on the skin and a fraction of the water evaporates. This action brings several benefits for various types of formulations including cleansers, sunscreens, and skin care.
\nIn addition, because Emulfree® CBG MB is surfactant free, it can be used in formulas designed for sensitive skin and those with strict “free-from” restrictions.
\n\n
\n Bi-gels offer an easy and innovative alternative to standard emulsions. They deliver unique benefits, and create new and inspirational textures, but are still easy to work with and well-suited to many product types. \n | \n![]() | \n
Emulfree® CBG MB naturally increases the water resistance of sunscreen formulations without the use of water resistance agents. Additionally, the light and cooling textures inherent to bi-gels are particularly well adapted to the hot temperatures in which sunscreens are typically used.
\nBecause of their quick-break effect on application, bi-gels are perfect for creating extremely light, cooling, and refreshing textures that are unachievable with standard emulsifiers. The after-feel on the skin is light and not greasy or tacky.
\nAs bi-gel formulas are applied on the skin, the oil phase becomes available to dissolve makeup and remove pigments from the skin.
\nBecause they don’t contain potentially irritating surfactants, bi-gels are well-suited to formulas targeting sensitive skin. The composition of Emulfree® CBG MB has been carefully studied to avoid skin reactions and ensure comfort.
\nThe clean eating trend is moving to beauty! More and more, consumers are looking for “clean beauty” formulas. With its skin friendly composition and an EWG rating of 1, bi-gels align perfectly with the clean beauty trend.
\n\n
![]() | \n\n Of course! Learn more about Emulfree® CBG MB here, or contact us to request a sample. \n | \n
A nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs. Self-emulsifies in aqueous media forming a fine dispersion, i.e., microemulsion (SMEDDS).
\n","names_kv":[{"keys":"USP NF Name","value":"Caprylocaproyl Polyoxyl-8 glycerides
\n"},{"keys":"EP Name","value":"Caprylocaproyl macrogol-8 glycerides
\n"},{"keys":"UNII Code (FDA)","value":"00BT03FSO2
\n"},{"keys":"Preferred Substance Name (FDA)","value":"PEG-8 CAPRYLIC/CAPRIC GLYCERIDES
\n"},{"keys":"Handbook of Pharmaceutical Excipients","value":"Polyoxylglycerides
\n"},{"keys":"Chemical description","value":"Consists of a small fraction of mono-, di- and triglycerides and mainly PEG-8 (MW 400) mono- and diesters of caprylic (C8) and capric (C10) acids
\n"}],"key_characteristics_kv":[{"keys":"Product form","value":"Liquid
\n"},{"keys":"Viscosity (mPa.s)","value":"80 – 110 (20°C)
\n"},{"keys":"CMC (mg/L, 25°C)","value":"42 ±24
\n"},{"keys":"HLB","value":"12
\n"}],"main_functionalities":"Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into microemulsion—LFCS Type III (SMEDDS). High purity guaranteed for stability and capsule compatibility. Safety of use is inferred by extensive toxicological data and precedence of use in approved pharmaceutical products.
\n","main_formulation_technologies":"Self-emulsifying lipid formulation for oral applications. Soft/hard gelatin capsule filling.
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