An optimized LBF enables solubilization of the entire therapeutic dose and maintains the drug in solubilized state throughout the digestion process.
\nTo speed up LBF development, we have produced tools to guide you at each stage of development:
\n1 – methods for saturation solubility screening
\n2 – database of solubility of drugs in common pharmaceutical excipients
\n3 – methods for miscibility and dispersability testing
\n4 – miscibility table
\n5 – in vitro lipolysis procedure
\n6 – guideline for preclinical studies
\nDay after day, skin and hair face stress, pollution, UV, and other harsh elements. This constant assault leads to dryness, dullness, and loss of radiance. Additionally, the damage to skin cells can lead to a loss of energy and efficiency. An effective way to restore radiance and energy is to bring more oxygen to cells and thereby boost their metabolism. By increasing their energetic potential, Phylderm® Vegetal stimulates cell renewal, amplifying skin radiance and making hair more resistant to environmental damage.
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\nJuergen Siepmann, Amina Faham, Sophie-Dorothée Clas, Ben J. Boyd, Vincent Jannin, Andreas Bernkop-Schnürch, Hang Zhao, Sébastien Lecommandoux, James C.Evans, Christine Allen, Olivia M. Merkel, Gabriella Costabile, Morgan R. Alexander, Ricky D.Wildman, Clive J.Roberts, Jean-Christophe Leroux
\nInternational Journal of Pharmaceutics, Volume 558, 10 March 2019, Pages 128-142
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\nThese topics were discussed at the Journées galéniques de Saint-Rémy de Provence in 2018, the Scientific Meeting sponsored by Gattefossé Foundation.
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The locavore movement primarily appeared in the USA West Coast with consumers giving the priority to food farmed closed to their home. It progressively expanded to the beauty industry, benefitting to both brands and consumers. The cosmetic industry finds in the locavore movement the opportunity to highlight forgotten local ingredients and to inject dynamism into regional economies. Consumers find in this “local spirit” a resonance with their value and a kind of reassurance.
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(1) Lightspeed/Mintel 2017, 1000 internet users aged 16+ per country
\n (2) https://www.happi.com/issues/2023-01-01/view_features/up-coming-indie-personal-care-brands-for-2023/
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\nIn this study the authors developed stable anhydrous and hydrous creams containing 40% Transcutol® HP, using predictive techniques to select appropriate excipients.
\n\nMasumi Dave, M.S., Jason Le Pree, Ph.D., R.Ph. – Gattefossé USA
\nIn this study the authors showed that Thermal Activity Monitoring is a useful technique to detect at early stage potential interaction between API and excipients, using less time and resources than conventional techniques.
\nTAM technique is used routinely in Gattefossé North American Technical Center of Excellence to speed up formulation development.
\n\nGelucire 48/16®: A Versatile Non-Ionic Solid Solubilizer for Tablets of Poorly Water-Soluble Drugs
\n Agnivesh Shrivastava, Ketkee Deshmukh, Nabil Farah, Sharda Gurram, Sunil Bambarkar
A solid dispersion of ticagrelor and Gelucire® 48/16 is prepared to increase drug solubility. The solid dispersion is converted into tablets. The formulated tablets showed improved dissolution rate compared to the market reference.
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\nDo you have any questions? We would be happy to answer your media inquiries. | \nClaudine Blondet press@gattefosse.com | \n
\n
\n\n
Gattefossé develops, manufactures and sells specialty ingredients for the personal care and pharmaceutical industries and offers a strong expertise in formulation for both of these activities.
\nGattefossé markets its products in more than 60 countries through 12 affiliated companies and a network of agents and distributors who provide technical and marketing support. Innovation, ethics, quality and long-term stability are the company key-drivers since the beginning.
\nGattefossé was founded in Lyon, France in 1880 by Mr. Louis Gattefossé to whom building strong relationship with customers was a priority. The company remains a family-run, independent business, and now employs more than 300 people worldwide.
\n\n\n
Click on the pictures to download HD portraits of our Chairman, Jacques Moyrand and our CEO, Eduardo De Purgly.
\nCopyright Véronique Védrenne
\n\n\n
April 15th, 2019 – GOLD rating for Gattefossé on EcoVadis
\n
April 3rd, 2019 – Gattefossé receives the Gold Innovation award for Emulium® Illustro
\n
March 9th, 2019 – Definicire™ receives PCHi Fountain Awards 2019 in China
\n
February 19th, 2019 – Gattefossé launches its new W/O emulsifier at in-cosmetics global
\n
December 17th, 2018 – COSMET’AGORA 2019, a new edition for Gattefossé’s tool INSPIRATION
\n
October 23, 2018 – Gattefossé North America announces the recipient of the 2018 Award for Excellence
\n
September 19th, 2018 – Gattefossé launches its first hair care
\n ingredient at in-cosmetics Latin America
\n
July 10th 2018 – Gattefossé renews its ISO 9001 certification and achieves the 2015 version
\n
June 5th 2018 – Official launch of ERI 360° Label
\n\n
\n
April 10th 2018 – Meet the #ConnectedGenerations at in-cosmetics global 2018
\n
March 29th 2018 – EnergiNius™: Gattefossé new launch at in-cosmetics Amsterdam 2018
\n
February 20th 2018 – Gattefossé Asia Pacific achieves ISO9001: 2015 certification
\n
January 25th 2018 – Gattefossé launches INSPIRATION tool
\n
November 10th 2017 – Gattefossé North America announces the recipient of the 2017 Award for Excellence
\n
November 6th 2017 – SIO-ADM, Gattefossé partner to bring USP/NF grade highly refined oils to North America
\n
October 18th 2017 – GATTEFOSSÉ and CYTOO join forces to investigate the biological effects of screen-emitted light on skin
\n
September 20th 2017 – The Gattefossé foundation supports two Health establishments
\n
July 28th 2017- Gattefossé Canada and Connect Chemicals announce distribution agreement
\n
April 26th 2017- Inauguration of our North America Technical Center of Excellence
Contact us to receive the Press Dossier
\n\n\n
Download the HD picture HD picture
\n
March 29th 2017 – Show true emotions at in-cosmetics London: two ingredients targeting the eye and lip contours
\n
March 21th 2017 – Gattefossé Foundation promotes the training of healthcare personnel in the use of Madagascan essential oils in Madagascar
\n
March 6th 2017 – Gattefossé certified RSPO Mass Balance
\n
February 8th 2017 – New launch: Gatuline® Link n Lift – Redesign the eye contour
\n
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A glyceride with an intermediate melting point containing PEG-8 esters. A powder wetting agent and lubricant for effervescent and fast-dissolving tablets.
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\nSolubilisation behaviour of poorly water-soluble drugs during digestion of solid SMEDDS
\nLipid-based nanosuspensions for oral delivery of peptides, a critical review
\nSelf-emulsifying peptide drug delivery systems: How to make them highly mucus permeating
\nCompritol® 888 ATO: a sustained release lipid matrix for once a day aceclofenac tablets
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Interest of carriers for the development of solid self-emulsifying drug delivery systems
\nBibliography on Gattefossé’s products. 2004-2005 review.
\nSolubilisation behaviour of poorly water-soluble drugs during digestion of solid SMEDDS
\nLipid-based nanosuspensions for oral delivery of peptides, a critical review
\nSelf-emulsifying peptide drug delivery systems: How to make them highly mucus permeating
\nCompritol® 888 ATO: a sustained release lipid matrix for once a day aceclofenac tablets
\nInterest of carriers for the development of solid self-emulsifying drug delivery systems
\nBibliography on Gattefossé’s products. 2004-2005 review.
\nDevelopment of immediate release pellets of poorly soluble compounds using Gelucire® 44/14
\nYvonne Rosiaux, Amandine Forest, Jean-Michel Girard, Carole Deleglise, Liz Sheehan and Delphine Marchaud
\n Journal of Drug Delivery Science and Technology 48 (2018) 437–449
In this study the authors used:
\n – A design of experiment, to evaluate the effect of process parameters (blending speed, chopper speed and coating time) on drug particle size.
\n – Potassium chloride as model drug.
The study showed:
\n – Individual particle coating was achieved at 450 rpm with 20% glyceryl distearate (Precirol® ATO 5) at 48°C
\n – High shear coating is as efficient as fluid bed coating for taste masking
\n – A trained sensory panel confirmed the effectiveness of the process on taste masking
C Morin and Y Rosiaux
\nRosiaux Y., Forest A., Girard J.M., Deleglise C., Marchaud D.
\nAAPS 2017
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