At Gattefossé, we base our industrial operations on two complementary know-how: lipid chemistry and plant extraction.
Gattefossé industrial activities are based on two fields of expertise: lipid chemistry and plant extraction.
Lipid chemistry (Lipochemical) engineering underpins the manufacturing of functional ingredients for the pharmaceutical and personal care industries. Production processes are based on esterification and interesterification of fatty substances of plant origin with hydrophilic molecules. These chemical reactions may be followed by downstream processes such as distillation or winterization to obtain finished product. No flammable solvents are used in these reactions.
Extraction processes are specifically designed for the raw materials we use – plants, part of plants and flowers – to obtain the highest quality actives and extracts.
Gattefossé has implemented an unique enduring industrial model, for over 60 years, which combines internal and outsourced production to trusted partners.
2177-7.03 Mineral Shield SPF50
\nSensitive and sun-intolerant skin deserves effective and sensorial UV protection too! Formulated with Emulium® Illustro, this sunscreen is neither sticky nor greasy on the skin. It is easy to apply and gives the skin a sunshine glow thanks to Gatuline® Radiance.
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2708-1.08 Refresh & Protect Bi-gel SPF30
\nRefresh and protect your skin with this sprayable suncare lotion. Thanks to Emulfree® CBG MB and its bi-gel technology, the formula is very fluid and refreshing during application and brings comfort without any greasy nor tacky afterfeel.
\n\n\n
2746-1.17 Dry Touch Lotion SPF50
\nPerfectly adapted for beach or daily use, this suncare lotion SPF50 formulated with Emulium® Mellifera MB spreads easily and penetrates very quickly into the skin. It leaves a very light and dry feel, as if no product had been applied.
\n\n\n
2532-2.01 High Protection Lotion SPF50
\nThis very high protection SPF50 is the best ally for sun-sensitive skin, whether in the city or at the beach. Thanks to Emulium™ Dolcea MB, the texture is fluid, soft and comfortable and leaves a very smooth, non-greasy and non-sticky afterfeel.
\n\n\n
2397-2.25 Extremely Soft Protection SPF30
\nThis SPF30 sunscreen doesn’t look like it! Thanks to Emulium® Dolcea MB, the texture is soft and comfortable and leaves a very smooth, non-greasy and non-sticky afterfeel. It can be used for daily care routines or at the beach.
\n\n\n
2494-1.13 Powdery Stick SPF50+
\nSome body areas are particularly prone to UV damage and deserve a foolproof sun protection: nose, cheekbones, scars, tattoos… This anhydrous sun stick is ideal due to its targeted application and its SPF50+. Once applied, it leaves a dry and powdery finish.
\n\n\n
2078-1.13 Fully Mineral Sunscreen SPF30
\nThis natural sunscreen SPF30, composed exclusively of non-nano mineral filters, is perfect for protecting your skin from UV rays at the beach while limiting environmental damage! Unlike most natural sunscreens, its texture is soft, easy to spread, and leaves no sticky nor greasy film thanks to Emulium® Illustro. A mix of active ingredients brings energy and radiance to the skin.
\n\n\n\n
This daily care is perfect to protect the skin from UV rays without worry. Its comfortable yet fluid texture penetrates quickly and leaves a soft film on the skin, while Solastemis™ protects the skin from the harmful effects of UVA and combats photo-aging.
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Find out more about these formulas in our booklet HERE.
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Other formulations are available on demand. Do not hesitate to contact your Gattefossé’s sales representative for more information about these new formulations or for any suncare development project to benefit from Gattefossé’s expertise.
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for successful preclinical studies with Gattefossé excipients"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":""},"categories":[49],"tags":[],"acf":{"content_not_translated":true,"equivalent_fr":false,"equivalent_en":false,"component":"PageGenericContentPharma","title":"Guide for successful preclinical studies","introduction":"","":false,"content":"\n
\n
\n
During lead optimization the scientist in preclinical development aims to maximize solubility and exposure of the test compound in animal models.
In this chapter we highlight the appropriateness of our single excipients to enhance the bioavailability of compounds. We further provide ready-to-use platform formulations that were reported efficient in vivo.
\n\n
\n
\n
Understanding the excipient’s safety and tolerability profile in various species is crucial to prevent unexpected formulation-related effects.
The compilation of our preclinical safety data helps you avoid long literature research and expensive evaluation of safe dosing volumes of Gattefosse excipients.How to correctly assess dosing volumes of excipient blends is also addressed in this chapter.
\n\n
\n
\n
Appropriate excipient handling and proper dosing to animals prevent misinterpretation of study results.
We herein underpin the need for some of our excipients to be handled with care and dosed under specific precautions. Considering these handling procedures and dosing recommendations provide the best practices to assure reliable outcomes.
\n\n
\n
\n
Functional excipients from Gattefosse are highly beneficial when used in enabled formulations for nonclinical evaluation and transfer to humans.
Our excipients are thoroughly characterized and used in various medicines worldwide. Practical information is compiled at the end of this document enabling rapid retrieval of key information: physicochemical properties, regulatory status and precedence of use.
\nVictor Claus , Helen Spleis, Christoph Federer, Katrin Z ̈oller, Richard Wibel, Flavia Laffleur, Camille Dumont, Philippe Caisse, Andreas Bernkop-Schnürch
\nInternational Journal of Pharmaceutics 639 (2023) 122964
\n In this study, lipophilicity of insulin glargine (IG) was successfully increased via hydrophobic ion pairing (HIP) with sodium octadecyl sulfate to enable incorporation into self-emulsifying
\n drug delivery systems (SEDDS). The SEDDS formulations F1 and F2 were administered to rats via oral gavage and resulted in a bioavailability of 0.55% and 0.44%, corresponding to a 7.7-fold and 6.2-fold increased bioavailability, respectively. Thus, incorporation of complexed insulin glargine into SEDDS formulations provides a promising approach to facilitate its oral absorption.
Rollie Fuller and Ron Permutt
\nDrug Development & Delivery – April 2023 issue
\n\n"},{"wysiwyg":"Jasmine Musakhanian, Jean-David Rodier and Masumi Dave
\nGattefossé
\nKetkee Deshmukh, Agnivesh Shrivastava, Sunil Bambarkar
\nPharma Times – Vol. 53 – No. 12, December 2021
\n\n\n"},{"wysiwyg":"
AGNIVESH SHRIVASTAVA , KETKEE DESHMUKH, RENUKA TIWARI, SUNIL BAMBARKAR, NABIL FARAH,
\n KAVITA SINGH
AAPS 2021
\nIn this study, Gelucire® 44/14 in type IV lipid-based formulation has been evaluated to increase the solubility and in vivo performance of ticagrelor.
\n\n"},{"wysiwyg":"American Pharmaceutical Review, February 2021
\nCamille Dumont, Cécile Morin
\n\nIntroduction
\nChapter I : Lipids, reliable partners to enhance oral bioavailability of poorly water-soluble drugs
\nChapter II : Lipids to enhance the intestinal permeability of poorly permeable drugs
\n
Chapter III : Targeting lymphatic absorption with appropriate lipid excipients selection
\nChapter IV : Mitigating food effect with lipid-based formulations
\nChapter V : Gattefossé range of functional excipients
\n for oral bioavailability enhancement
\n
Inayet Ellis
\nTablets & Capsules, April 2020
\n\n"},{"wysiwyg":"Ben J. Boyd, Christel A.S. Bergström, Zahari Vinarov, Martin Kuentz, Joachim Brouwers, Patrick Augustijns, Martin Brandl, Andreas Bernkop-Schnürch, Neha Shrestha, Véronique Préat, Anette Müllertz, Annette Bauer-Brandl, Vincent Jannin
\nEuropean Journal of Pharmaceutical Sciences, Volume 137, 2019, 104967,
\n ISSN 0928-0987, https://doi.org/10.1016/j.ejps.2019.104967.
In this excellent review article issued from the UNGAP program (European Network on Understanding Gastro-intestinal Absorption-related Process) you will find relevant and up-to-date information on:
\n[Bioavailability enhancement of active pharmaceutical ingredients through formulation strategies]
\nE Levacher, C Buffangeix, MJ Celadon, I Decorte, P Gestin, J Hecq, F Jego, B Paillard, A Plantefeve, X Thomas
\nThe SFSTP commission on Bioavailability published an article reviewing the formulation strategies to enhance the bioavailability of APIs.
\nInterestingly this article is both in French and English languages.
\n\nI Introduction
\nII Prerequisites
\n1 Initial identification and characterization of the active ingredient
\n 1.1 Physico-chemical characteristics
\n 1.2 Impact of physicochemical characteristics on absorption
\n 1.3 Passive diffusion prediction tools
\n 1.4 In silico prediction
\n 2 Biopharmaceutical classifications
III Formulation strategies
\n1 prerequisites
\n 2 techniques for increasing the dissolution rate
\n 3 Solubility enhancement technologies
\n 4 Improving the permeability, oral route
IV Control, assessment, prediction of the bioavailability
\n1 Physicochemical control methods for the manufacturing intermediates and finished products
\n 2 Assessing an dpredicting the bioavailability of the formulations
V Alternative strategy: changing the route of administration
\nVI Conclusion: decision tree
\nPharma Times September 2019 – Special issue
\n\nLipid excipients in pharmaceutical technologies
\n Nabil FARAH and Joel DENIS
Lipidic excipients in drug delivery for solubility and bioavailability enhancement
\n Prashantkumar K. PARMAR, Srilaxmi G. RAO, Arvind KK. BANSAL
From exploration of lipids to its exploitation in market: Pharmaceuticals, Nutraceuticals and Herbal
\n Saurabh ARORA, Abhinav GARG, Karishma KAPOOR
A snapshot of lipid excipients for topical formulations
\n Renuka TIWARI, Ketkee DESHMUKH, Agnivesh SHRIVASTAVA, Kanchan KOHLI
Strategic lipid-based delivery interventions for enhancing oral bioavailability of BCS II/IV drugs
\n Teenu SHARMA, Ranjot KAUR, Sumant SAINI, Atul JAIN, Bhupinder SINGH
Unleashing role of excipients in overcoming formulation challenges
\n Meenakshi VENKATARAMAN, Megha MARWAH, Mangal NAGARSENKER
Role of lipid excipients in oral sustained release drug delivery systems
\n Divya JAIN, Namita DESAI
Ketkee DESHMUKH, Agnivesh SHRIVASTAVA, Sunil BAMBARKAR, Nabil FARAH, Kavita SINGH
\nIn this case study using curcuminoids as model drug, the authors show that in vitro lipolysis test is a useful tool to predict in vivo performance
\nPoster CRS 2019
\n\n"},{"wysiwyg":"Kapilkumar Vithani, Vincent Jannin, Colin W. Pouton, Ben J. Boyd
\nIn this review article, the authors explain the importance of the colloidal structures formed during dispersion and digestion of self emulsifying lipid-based formulations on drug solubilization and absorption.
\nA review of the techniques used to characterize the colloidal structures is also carried out.
\n\n"},{"wysiwyg":"Dr. Jason LePree Drug Development & Delivery, Issue: October 2017, Posted Date: 9/29/2017 This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome impediments to good bioavailability of therapeutic actives, including poor water solubility, low permeability, and degradation by stomach acid or enzymes in vivo.
\n\n"},{"wysiwyg":"September 2015 This white paper describes the important milestones achieved in lipid based formulation (LBF) development for oral drug delivery. Collaborative research between academic and industrial partners has increased understanding of the functional properties of lipid excipients and the role they play in solubilizing poorly water soluble compounds. It has also led to the development of in vitro – in vivo predictive analytical tools. The key scientific articles describing these milestones are collected in this one White Paper, providing a single source of practical information for those interested in lipid formulation development.
\n\n"},{"wysiwyg":"Vincent Jannin, Stéphanie Chevrier, Matthieu Michenaud, Camille Dumont, Silvia Belotti, Yann Chavant, Fédéric Demarne.
\nThis acticle describes the work undertaken in Gattefossé R&D labs (St Priest) to develop lipid formulations for low to medium lipophilicity API: piroxicam, nifedipine and curcurmin and evaluate the effect of in-vitro digestion on the solubilizing capacity of the formulations.
\n\n"},{"wysiwyg":"Vincent Jannin, Camille Dumont, Hamza Benhaddou, Stéphanie Chevrier, Yann Chavant, Christophe Voutsinas, Frédéric Demarne
\nAAPS 2014
\n\n"}],"content_not_translated":true,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/pages/26578"}],"collection":[{"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/comments?post=26578"}],"version-history":[{"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/pages/26578/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/media?parent=26578"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/categories?post=26578"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/our-business/wp-json/wp/v2/tags?post=26578"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"publications-on-pharmaceutical-foams":{"id":4241,"date":"2017-05-08T07:34:48","date_gmt":"2017-05-08T07:34:48","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=4241"},"modified":"2023-01-10T10:04:34","modified_gmt":"2023-01-10T08:04:34","slug":"publications-on-pharmaceutical-foams","status":"publish","type":"page","link":"https://www.gattefosse.com/pharmaceuticals-special-content/publications-on-pharmaceutical-foams/","title":{"rendered":"Publications on pharmaceutical foams"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Publications on pharmaceutical foams | Gattefossé","_yoast_wpseo_metadesc":"Find out Gattefossé publications on pharmaceutical foams."},"categories":[36],"tags":[],"acf":{"component":"PageSpecialContentPharma","title":"Publications on pharmaceutical foams","introduction":"List of Gattefossé publications on pharmaceutical foams.","":false,"content":[{"wysiwyg":"E Dauphin-Chanard, C André and D Marchaud
\nPoster – AAPS 2016
\n\n"},{"wysiwyg":"E Dauphin-Chanard, C André and D Marchaud
\nPoster AAPS 2016
\n\n\n"},{"wysiwyg":"
November 2016
\nPharmaceutical foams are becoming more popular probably due to more topical medicines being switched to OTC and the need to innovate and differentiate ‘brands’ and an increasing awareness of the importance of formulating to deliver sensorial benefits and positive impact on patient experience and adherence. Gattefossé, as a leading provider of excipients for the pharmaceutical industry, manufactures solubilizers and texturizers for skin drug delivery. In this white paper we give formulation tips for propellant and propellant-free foams with guidelines on how to formulate and select excipients and case studies with model drugs.
\n\n"},{"wysiwyg":"E Dauphin-Chanard, C André and D Marchaud
\nPoster Skin Forum, June 2016
\n\n"},{"wysiwyg":"E Dauphin-Chanard, C André, D Hoste and D Marchaud
\nPoster PBP, April 2016
\n\n"}],"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/4241"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=4241"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/4241/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=4241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=4241"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=4241"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"publications-on-3d-printing":{"id":11769,"date":"2018-12-10T09:23:27","date_gmt":"2018-12-10T07:23:27","guid":{"rendered":"https://www.gattefosse.com/?page_id=11769"},"modified":"2022-05-03T10:00:32","modified_gmt":"2022-05-03T08:00:32","slug":"publications-on-3d-printing","status":"publish","type":"page","link":"https://www.gattefosse.com/sustainable-actions/pharmaceuticals-special-content/publications-on-3d-printing/","title":{"rendered":"Publications on 3D printing"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Publications on 3D printing | Gattefossé","_yoast_wpseo_metadesc":"Find out Gattefossé publications on 3D printing"},"categories":[36],"tags":[],"acf":{"component":"PageSpecialContentPharma","title":"Publications on 3D printing","introduction":"List of Gattefossé publications on 3D printing.","":false,"content":[{"wysiwyg":"\n\n
\n"},{"wysiwyg":"
Vithani K, Goyanes A, Jannin V, Basit AW, Gaisford S, Boyd BJ
\nPharm Res. 2019 May 16;36(7):102.
\n doi: 10.1007/s11095-019-2639-y.
In this study, the authors show that solid SMEDDS can be produced with a 3D printing process and solid and semi-solid lipid excipients. The proof of concept is established with cinnarizine and fenofibrate as model drugs.
\n\n"},{"wysiwyg":"Vithani K, Goyanes A, Jannin V, Basit AW, Gaisford S, Boyd BJ.
\nPharm Res. 2018 Nov 7;36(1):4. doi: 10.1007/s11095-018-2531-1.
\nIn this review article, the authors describe the various technologies used for 3D printing and their application in the pharmaceutical field.
\nThe potential for lipids and the opportunities for lipid-based drug delivery systems are highlighted.
\n\n"},{"wysiwyg":"KapilkumarVithani, Alvaro Goyanes, Vincent Jannin, Simon Gaisford, Ben Boyd
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\n\n
\n
La qualité est pour nous un facteur-clé de progrès. Elle est partie intégrante de tout ce que nous entreprenons, depuis nos activités de R&D jusqu’à la commercialisation des produits.
\nNos politiques de qualité sont constamment mises à niveau afin de répondre aux attentes de nos clients et de les anticiper. Nous sommes régulièrement audités par nos principaux clients et nous nous efforçons d’améliorer de façon continue nos normes de qualité, validées par plusieurs certifications.
\n\n
\n
\n
Nous appliquons strictement les bonnes pratiques de fabrication (BPF), que ce soit pour nos excipients pharmaceutiques ou nos ingrédients cosmétiques.
\n\n
\n
Dans le cadre de notre politique de management, nous avons mis en place des mesures de sécurité strictes visant à prévenir les risques liés à nos activités – fabrication, chaîne d’approvisionnement, logistique et R&D – et nos installations – lignes de production, laboratoires d’applications et bâtiments administratifs.
\nLa formation de nos équipes fait l’objet d’une attention particulière de notre part et passe notamment par des campagnes de sensibilisation régulières. Nous définissons des indicateurs et mettons systématiquement en place des plans d’action pour assurer la sécurité de nos collaborateurs et l’innocuité de nos produits sur le long terme.
\n\n
Cet engagement en faveur de la qualité nous permet de partager des références communes avec nos clients en termes de systèmes et de normes industrielles et de les intégrer à nos propres procédures.
\n"},{"wysiwyg":"\n
\n
Pour encourager l’innovation responsable, nos processus de production ont été modernisés avec pour objectif de dépenser moins d’énergie, de réduire nos déchets et de maximiser le recyclage.
\nDepuis de nombreuses années, Gattefossé s’engage en faveur du développement durable, en réduisant sensiblement sa consommation énergétique tout en augmentant sa capacité de fabrication.
\nNotre entreprise protège l’environnement en sélectionnant avec soin des matières premières d’origine naturelle pour ses processus de production. Ainsi, Gattefossé est membre depuis 2010 de l’organisation RSPO qui soutient les coopératives et les producteurs d’huile de palme responsables. En 2017, l’entreprise a obtenu la certification RSPO « Mass Balance » pour son site de fabrication en France. Gattefossé utilise également une huile de palme certifiée « Segregated » pour sa gamme d’ingrédients cosmétiques Lipocire™.
\nGattefossé offre la garantie que ses matières premières proviennent de sources fiables, identifiables et renouvelables, grâce à un traçage rigoureux de leurs origines et des méthodes de production. Nous établissons avec nos fournisseurs des relations pérennes et les considérons comme de véritables partenaires stratégiques.
\n\n
\n
\n
Nous avons la conviction que la future croissance de notre entreprise dépend des talents qui la composent à travers le monde et qui œuvrent au quotidien pour faire de Gattefossé un acteur mondial. Le groupe est fier de sa forte culture d’entreprise, influencée par les personnalités de ses fondateurs et de ses dirigeants. Ils ont su faire évoluer la société tout en restant fidèles au code éthique établi dès sa création.
\n→ A propos de la culture d’entreprise de Gattefossé
\n"},{"wysiwyg":"\n
\n
Gattefossé a établi des liens étroits avec la communauté scientifique internationale et partage ses connaissances par le biais de publications, de séminaires et de conférences. L’entreprise soutient des doctorants et gère des projets de recherche sous contrat avec divers groupes universitaires dans le monde.
\n\n
\n
\n
\n
\n
Organisées sous l’égide de la Fondation Gattefossé, les Journées Galéniques de Saint-Rémy de Provence rassemblent chaque année la communauté scientifique internationale industrielle et académique autour d’un thème lié à la formulation des médicaments. Cet évènement vise à favoriser les échanges scientifiques en pharmacie galénique pour faire progresser les connaissances et les techniques dans ce domaine.
\nEn organisant ces rencontres, Gattefossé poursuit l’œuvre initiée dans les années 60 par Henri-Marcel Gattefossé, qui plaça l’entreprise sous le signe du dialogue avec les chercheurs du monde entier.
\nLes conclusions des Journées Galéniques sont publiées sous forme d’un Bulletin Technique* mis à la disposition de tous les professionnels du secteur pharmaceutique.
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\n
Gattefossé’s four application laboratories are located in France, China, India, and the United States. These strategic positions permit close, local relationships with our customers.
\n
\n
\n
\n
Nature is a constant inspiration for cosmetics ingredients, but plants are not the only sources of natural actives. Mineral Matters™ liquid stone extracts apply special technology to extract important minerals from precious stones and make them bioavailable to the skin. The result is a unique line of substantiated stone actives that enhance and protect. Mala’Kîte™ is a protective copper complex extracted from malachite. A powerful free radical scavenger, it boosts cellular defenses offering protection against aging and detoxifying benefits. Mala’Kîte™ effectively protects both skin and hair against environmental stress. See the other actives in this Mineral Matters™ line:
\nOnce used as an ore to produce copper, today malachite is more well known as a gemstone. This beautiful stone has a green color that does not fade over time or through exposure to light, ranging from a pastel blue-green all the way to a dark green verging on black.
\n\n
The stones used to create Mala’Kîte™ liquid stone extract are sourced in central Africa. Preservative free.
\nIn vitro tests prove Mala’Kîte™ effectively
\nE Dauphin-Chanard, D Hoste and D Marchaud Poster – PBP 2018
\n\n"},{"wysiwyg":" Access our publications on pharmaceutical foams
E Dubois, E Dauphin-Chanard, D Hoste and D Marchaud Poster – AAPS 2008
\n\n"}],"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/qualification-des-excipients/wp-json/wp/v2/pages/9032"}],"collection":[{"href":"https://www.gattefosse.com/qualification-des-excipients/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/qualification-des-excipients/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/qualification-des-excipients/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/qualification-des-excipients/wp-json/wp/v2/comments?post=9032"}],"version-history":[{"href":"https://www.gattefosse.com/qualification-des-excipients/wp-json/wp/v2/pages/9032/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/qualification-des-excipients/wp-json/wp/v2/media?parent=9032"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/qualification-des-excipients/wp-json/wp/v2/categories?post=9032"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/qualification-des-excipients/wp-json/wp/v2/tags?post=9032"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"microemulsion":{"id":2931,"date":"2017-04-25T09:41:32","date_gmt":"2017-04-25T09:41:32","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=2931"},"modified":"2021-02-05T17:12:03","modified_gmt":"2021-02-05T15:12:03","slug":"microemulsion","status":"publish","type":"page","link":"https://www.gattefosse.com/pharmaceuticals-content/microemulsion/","title":{"rendered":"Microemulsion"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Exipients for microemulsion | Gattefossé","_yoast_wpseo_metadesc":"Understand how microemulsions are formed spontaneously by gentle mixing of oily vehicle, surfactant/cosurfactant and water."},"categories":[49],"tags":[],"acf":{"component":"PageGenericContentPharma","title":"Microemulsion","content":"Microemulsions are thermodynamically stable systems formed spontaneously by gentle mixing of their components: oily vehicle, surfactant/cosurfactant, and water.
\nA pseudoternary phase diagram determines the respective concentrations of the components yielding a microemulsion. Watch our video for more information on how to develop pseudoternary diagrams.
\n\n\n
Labrasol® is a liquid oil-in-water (O/W) surfactant (HLB=12) with excellent solubilizing capacity. It is often used in combination with a cosurfactant such as Plurol® Oleique CC 497 (HLB=3).
\nLabrafac™ Lipophile WL 1349 is an oily vehicle with emollient properties.
\nOur formulators have developed microemulsions for the preparation of pharmaceutical foams using propellant-free devices. Case studies with model drugs show that a foam can easily be produced with a microemulsion-based formulation.
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\n
On October 16, 2018, the prize (10 000€) was awarded to Dr. Anne Moro’s team (University Hospital of La Réunion) at the Foundation’s headquarters in Lyon (France).
Anne Moro has a degree in clinical aromatherapy from the University of Strasbourg. She coordonates the MAFACE expertise center in La Réunion for the treatment of facial malformations and cleft lip and palate. For the past 3 years, she has been using essential oils at the University Hospital of La Réunion to improve the healing of wounds and scars, prevent infections and calm the pain and stress of her patients. Anne Moro also contributes to a more general use of aromatherapy in the hospital: at the pharmacy, in the operating room and within the voluntary services. A PHRI* (hospital research nurse program) is underway for a research project that should begin in December 2018.
\n\n With the association TSIKY RUN, she uses essential oils during humanitarian missions in Madagascar. The aim of the association is, on one hand, to support patients born with a cleft lip and palate (harelip) and to treat pre and post operative care with essential oils. On the other hand she trains Malagasy doctors in the use of essential oils, as a complementary care strategy or sometimes as a replacement to allopathic treatments. These missions are supported by the University Hospital of La Réunion, which grants leave to its employees who take part in humanitarian missions and lends surgical equipment as well.
\n\n The Steering Committee on Aromatherapy has rewarded the innovative nature of the use of essential oils in pediatrics, particularly in repair surgery of the cleft lip and palate and in the operating room. Besides, the location of the project in a country that distills oils, the humanitarian nature of missions in Madagascar facilitating access to care for disadvantaged families and the quality of the protocols put in place were particularly emphasized.
\n\n
\n
On October 9, 2018, the Foundation Grant (5 000€) was awarded to the team of Marin Hospital of Hendaye (Hôpital Marin de Hendaye / Assistance Publique – Hôpitaux de Paris). Mr Andoni Alli, hospital pharmacist, is in charge of the aromatherapy approach. Trained at the Dijon DU, he initiated this approach in 2013.
\nThis rehabilitation and recuperative care facility uses aromatherapy as complementary medicine in the treatment of wounds, mycoses, gastrointestinal disorders, herpes, agitation, anxiety, insomnia, spasticity and pain in patients with heavy disabilities or rare neurological and endocrine diseases.
\nThe Steering Committee on Aromatherapy has rewarded the innovative nature of the use of oils in this type of establishment, the diversity of pathologies and areas of intervention, the internal dynamics initiated by the involvement of the pharmacist and the director of health, the training of a hundred people and the designation of aromatherapy referents in each department concerned, as well as the validation of protocols by the department of care and the doctors of the poles.
\n\n
\n
On October 12, 2018, the Foundation Grant was awarded to the team of the Barthélemy Durand Public Health Institution (EPS) in Etampes (Essonne, France), which aromatherapy approach is carried by Mrs. Ioana Farcas, hospital pharmacist, trained in IUD Phyto-aroma of Paris V University.
\nThe Steering Committee on Aromatherapy has rewarded the innovative nature of the use of essential oils in the services of this reference institution in mental health since 2015, the supervision of the use of essential oils by a team of pharmacists, and the willingness to set up a scientific aromatherapy program with staff training and evaluation of the decline in chemical drug intake.
\nThe Committe also appreciated the engaging awareness and communication measures about aromatherapy and the inclusion of the development of the use of essential oils in the establishment project, within a global development of the non-medicated therapies.
\n\n\n
Learn more about the prize and grants
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White paper, November 2014
\nFunctional excipients are critical to the successful application of HME to resolve formulation challenges. Whilst polymers show potential in both controlled release and in improving the solubility and dissolution of poorly soluble compounds they are not ideal materials for extrusion. Lipid excipients are distinctly different to polymers and behave differently in HME. This article highlights two glyceride-esters: Compritol® 888 ATO and Precirol® ATO 5. They melt at relatively low temperatures and recrystallize quickly. They extrude well and can produce strand-like extrudates which can be down streamed into powders or granules.
\nThese glyceride-esters can be used as release retarding agents/dissolution modifiers for both insoluble and soluble drugs even for high drug loading. In combination with plastic polymers they also can act as plasticizer/processing aid enabling lower temperature process and continuous production.
\nAt Gattefossé we aim to share our knowledge to help formulators use lipid excipients to their best advantage.
\n\n"},{"wysiwyg":"Yvonne Rosiaux, Jean-Michel Girard, Florence Desvignes, Cédric Miolane, Delphine Marchaud AAPS 2014
\n\n"},{"wysiwyg":"Yvonne Rosiaux, Jean-Michel Girard, Florence Desvignes, Cédric Miolane, Delphine Marchaud AAPS 2014
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\n\n"},{"wysiwyg":"Yvonne CUPPOK, Jean-Michel GIRARD, Helena SCHREINER, Simon SCHNABEL, Albrecht HUBER, Delphine MARCHAUD AAPS 2012
\n\n"},{"wysiwyg":"Justin M. Keen, Justin R. Hughey, Ryan C. Bennett, Vincent Jannin and James W. McGinity AAPS 2011
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\nClick here for more information
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Emulium Dolcea, Cosmétique solide, Oléochimie, Oilkemia 5S polymer\n
As part of its mission to promote the use of essential oils in healthcare establishments, the Gattefossé Foundation has created grants to reward and encourage the development of aromatherapy initiatives, in France and abroad.
\nA 5000€ grant has just been awarded to the AROVA Association (Aromatherapists of the Vakinankaratra), which brings together doctors trained in aromatherapy and aims to teach the medical and paramedical staff of the island of Madagascar the use of essential oils. It then provides them with blends of oils for their daily practice in care centers. AROVA has trained nearly 80 professionals since 2013 and intends to train an additional 100 people thanks to this funding.
\nThis project has been selected by the Gattefossé Foundation because it stands at the heart of public health, social economy and sustainable development issues. Despite the fact that Madagascar produces over 30 different essential oils, the sector remains quite disorganised and all the oils produced are exported to foreign markets, benefiting neither the local populations nor the economy. Today, the essential oils used by the association are supplied at a wholesale price by a French NGO called Coeur de forêt. While the General Directorate of the Ministry of Health of Madagascar has advocated for the development of phyto-aromatherapy, the Foundation intends with this grant to encourage the use of local essential oils.
\nRead the press release
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\nJ. Excipients and Food Chem. 8 (1) 2017 – 5
\nIn the present study the lubricant capacity of Compritol® HD5 ATO was compared with commonly used amphiphilic lubricants. The
\n effect of the concentration and mixing time on flow properties, tablet ejection force, hardness, disintegration time and rate of dissolution of paracetamol tablets was evaluated.
\n The physical properties of the lubricants such as crystallinity, wettability, thermal behaviour and surface area were also measured.
\n Compritol® HD5 ATO was found to be an as effective a lubricant for a fast disintegrating paracetamol formulation containing microcrystalline cellulose, lactose and PVP prepared by wet granulation in comparison with sodium stearyl fumarate and PEG 6000.
Ketkee Deshmukh, Gayatri Khanvilkar, Chhanda Kapadia
\nPoster presented at the 66th Indian Pharmaceutical Congress held at Hyderabad during 23rd – 25th of January 2015
\n\n"},{"wysiwyg":"Jannin, V. Bérard, S. Chevrier, A. Malmazet, Y. Chavant, F. Demarne, C. Andrès
\nJournal of Drug Delivery Science and Technology, Volume 23, Issue 2, 2013, Pages 181-185
\n\n\n"},{"wysiwyg":"
V Jannin, V Bérard, A N’Diaye, C Andrès, Y Pourcelot
\nInternational Journal of Pharmaceutics. Volume 262, Issues 1–2, 27 August 2003, Pages 39–45
\nIn this study, the lubricant performance of Compritol 888 ATO is assessed in a classical blending process or by hot melt coating. The results suggest that the hot melt coating process induces an homogeneous repartition of the lubricant on the lactose surface,
\n contrary to classical blending procedure. Thus, lubrication by hot melt coating seems to be a very efficient procedure. It could be used specifically for large surface area particulate systems producing a lot of friction.
A. N’Diaye, V. Jannin, V. Bérard, C. Andrès, Y. Pourcelot
\nInternational Journal of Pharmaceutics. Volume 254, Issue 2, 26 March 2003, Pages 263–269
\nIn this study the lubricant capacity of Compritol HD5 ATO is compared to Compritol 888 ATO. It shows that mixing lubricants with Lactopress present no structural differences and that they have equivalent compressibility and cohesiveness. This study concludes
\n that Compritol HD5 ATO could be a very interesting excipient because it associates the glyceryl dibehenate lubricant capacity with the polyethylene glycol property of enhanced dissolution.
A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms associated with skin penetration enhancement.
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\n","link":"https://www.gattefosse.com/back/files/Gattefosse_brochure_oral%20drug%20delivery%202020.pdf"},{"image":{"id":13505,"alt":"","title":"Gattefosse_Topical-drug-delivery-brochure8167-212x300","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Gattefosse_Topical-drug-delivery-brochure8167-212x300-1.jpg","width":212,"height":300,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Gattefosse_Topical-drug-delivery-brochure8167-212x300-1-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Gattefosse_Topical-drug-delivery-brochure8167-212x300-1-212x300.jpg","medium-width":212,"medium-height":300,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Gattefosse_Topical-drug-delivery-brochure8167-212x300-1.jpg","medium_large-width":212,"medium_large-height":300,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Gattefosse_Topical-drug-delivery-brochure8167-212x300-1.jpg","large-width":212,"large-height":300,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Gattefosse_Topical-drug-delivery-brochure8167-212x300-1.jpg","post-thumbnail-width":212,"post-thumbnail-height":300,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Gattefosse_Topical-drug-delivery-brochure8167-212x300-1.jpg","twentyfourteen-full-width-width":212,"twentyfourteen-full-width-height":300}},"title":"Lipid excipients for topical drug delivery","text":"Emulsifiers, thickeners, solubilizers and penetration enhancers will have no secret for you after reading this brochure!
\n","link":"https://www.gattefosse.com:443/back/files/Gattefosse_brochure_topical drug delivery with lipid excipients.pdf"},{"image":{"id":13513,"alt":"","title":"Gattefosse_32194-212x300","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Gattefosse_32194-212x300-1.jpg","width":212,"height":300,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Gattefosse_32194-212x300-1-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Gattefosse_32194-212x300-1-212x300.jpg","medium-width":212,"medium-height":300,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Gattefosse_32194-212x300-1.jpg","medium_large-width":212,"medium_large-height":300,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Gattefosse_32194-212x300-1.jpg","large-width":212,"large-height":300,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Gattefosse_32194-212x300-1.jpg","post-thumbnail-width":212,"post-thumbnail-height":300,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Gattefosse_32194-212x300-1.jpg","twentyfourteen-full-width-width":212,"twentyfourteen-full-width-height":300}},"title":" Lipid excipients for rectal drug delivery","text":"Discover our wide range of suppository bases and how Gattefossé expertise can speed up your development!
\n","link":"https://www.gattefosse.com:443/back/files/Brochure Rectal drug delivery_2020.pdf"},{"image":{"id":13508,"alt":"","title":"Offical-Cannabinoid_internet_Page_01-233x300","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Offical-Cannabinoid_internet_Page_01-233x300-1.jpg","width":233,"height":300,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Offical-Cannabinoid_internet_Page_01-233x300-1-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Offical-Cannabinoid_internet_Page_01-233x300-1-233x300.jpg","medium-width":233,"medium-height":300,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Offical-Cannabinoid_internet_Page_01-233x300-1.jpg","medium_large-width":233,"medium_large-height":300,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Offical-Cannabinoid_internet_Page_01-233x300-1.jpg","large-width":233,"large-height":300,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Offical-Cannabinoid_internet_Page_01-233x300-1.jpg","post-thumbnail-width":233,"post-thumbnail-height":300,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Offical-Cannabinoid_internet_Page_01-233x300-1.jpg","twentyfourteen-full-width-width":233,"twentyfourteen-full-width-height":300}},"title":"Lipid excipients for cannabinoid drug products","text":"Find out about our solutions for cannabinoid drug products.
\n","link":"https://www.gattefosse.com/back/files/Brochure_Gattefosse%20lipid%20excipients%20for%20cannabinoid%20drug%20products.pdf"},{"image":{"id":13507,"alt":"","title":"Lipid-Excipients-in-Pediatric-Dosage-Form-214x300","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Lipid-Excipients-in-Pediatric-Dosage-Form-214x300-1.jpg","width":214,"height":300,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Lipid-Excipients-in-Pediatric-Dosage-Form-214x300-1-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Lipid-Excipients-in-Pediatric-Dosage-Form-214x300-1-214x300.jpg","medium-width":214,"medium-height":300,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Lipid-Excipients-in-Pediatric-Dosage-Form-214x300-1.jpg","medium_large-width":214,"medium_large-height":300,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Lipid-Excipients-in-Pediatric-Dosage-Form-214x300-1.jpg","large-width":214,"large-height":300,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Lipid-Excipients-in-Pediatric-Dosage-Form-214x300-1.jpg","post-thumbnail-width":214,"post-thumbnail-height":300,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Lipid-Excipients-in-Pediatric-Dosage-Form-214x300-1.jpg","twentyfourteen-full-width-width":214,"twentyfourteen-full-width-height":300}},"title":"Pediatric medicines with lipid excipients","text":"Find out our solutions for oral, topical and rectal dosage forms suitable for pediatric patients.
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\n","link":"https://www.gattefosse.com/back/files/Brochure_veterinary%20medicines%20with%20Gattefosse%20excipients.pdf"},{"image":{"id":22113,"alt":"","title":"Cover BAE leaflet 2020","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Cover-BAE-leaflet-2020.jpg","width":1604,"height":2269,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Cover-BAE-leaflet-2020.jpg","thumbnail-width":106,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Cover-BAE-leaflet-2020.jpg","medium-width":212,"medium-height":300,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Cover-BAE-leaflet-2020.jpg","medium_large-width":474,"medium_large-height":671,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Cover-BAE-leaflet-2020.jpg","large-width":474,"large-height":671,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Cover-BAE-leaflet-2020.jpg","post-thumbnail-width":263,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Cover-BAE-leaflet-2020.jpg","twentyfourteen-full-width-width":407,"twentyfourteen-full-width-height":576}},"title":"Lipid-based formulations a winning strategy to overcome oral bioavailability challenges","text":"Learn more about the different capacities of lipid excipients on oral bioavailabilty.
\n","link":"https://www.gattefosse.com:443/back/files/Brochure_Gattefosse_Lipid-based formulations a winning strategy to overcome oral bioavailability challenges.pdf"},{"image":{"id":29250,"alt":"","title":"couverture-sustained-drug-release-2023","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/couverture-sustained-drug-release-2023.jpg","width":212,"height":300,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/couverture-sustained-drug-release-2023-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/couverture-sustained-drug-release-2023-212x300.jpg","medium-width":212,"medium-height":300,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/couverture-sustained-drug-release-2023.jpg","medium_large-width":212,"medium_large-height":300,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/couverture-sustained-drug-release-2023.jpg","large-width":212,"large-height":300,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/couverture-sustained-drug-release-2023.jpg","post-thumbnail-width":212,"post-thumbnail-height":300,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/couverture-sustained-drug-release-2023.jpg","twentyfourteen-full-width-width":212,"twentyfourteen-full-width-height":300}},"title":"Sustained drug release with Compritol® 888 ATO","text":"Compritol® 888 ATO many advantages in sustained release are highlighted and its use in single or dual SR matrix is explained.
\n","link":"https://www.gattefosse.com:443/back/files/Gattefosse brochure Sustained-drug release with Compritol 888 ATO 2023_4t.pdf"},{"image":{"id":29251,"alt":"","title":"couverture-compritol888ATO-2023","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/couverture-compritol888ATO-2023.jpg","width":212,"height":300,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/couverture-compritol888ATO-2023-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/couverture-compritol888ATO-2023-212x300.jpg","medium-width":212,"medium-height":300,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/couverture-compritol888ATO-2023.jpg","medium_large-width":212,"medium_large-height":300,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/couverture-compritol888ATO-2023.jpg","large-width":212,"large-height":300,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/couverture-compritol888ATO-2023.jpg","post-thumbnail-width":212,"post-thumbnail-height":300,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/couverture-compritol888ATO-2023.jpg","twentyfourteen-full-width-width":212,"twentyfourteen-full-width-height":300}},"title":"Compritol® 888 ATO: the lubricant for challenging pharmaceutical tablets","text":"Inert, robust and efficient: 3 words that summarize the outstanding benefits of Compritol® 888 ATO as lubricant for pharmaceutical tablets
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\nDiscover our full range of functional excipients to develop exciting topical dosage forms aiming at encouraging patient adherence to topical treatments.
\n","link":"https://www.gattefosse.com:443/back/files/Gattefosse Brochure Skin-Friendly Textures_2d.pdf"},{"image":{"id":25979,"alt":"","title":"Capture emlufree duo","caption":"","description":"","mime_type":"image/png","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Capture-emlufree-duo.png","width":737,"height":759,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Capture-emlufree-duo-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Capture-emlufree-duo-291x300.png","medium-width":291,"medium-height":300,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Capture-emlufree-duo.png","medium_large-width":474,"medium_large-height":488,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Capture-emlufree-duo.png","large-width":474,"large-height":488,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Capture-emlufree-duo-672x372.png","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/03/Capture-emlufree-duo-737x576.png","twentyfourteen-full-width-width":737,"twentyfourteen-full-width-height":576}},"title":"Emulfree® Duo","text":"An interactive brochure for a richer experience on this brand new stabilizing agent for bi-gels!
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A case study with fenofibrate
\nE. Dauphin-Chanard ; JM. Girard ; C. Deleglise ; P. Caisse
\nGattefossé SAS – Saint-Priest – France
\n\n"},{"wysiwyg":"Agnivesh Shrivastava, Ketkee Deshmukh, Sunil Bambarkar, Nabil Farah, Kavita Singh
\nPharmSci AAPS 2019
\nIn this study the authors developed a type IV lipid-based formulation to improve solubility and bioavailability of ticagrelor. The in vitro lipolysis test was shown to be a good tool to predict in vivo performance.
\n\n"},{"wysiwyg":"\n Agnivesh Shrivastava, Ketkee Deshmukh, Nabil Farah, Sharda Gurram, Sunil Bambarkar
\nPharmSci AAPS 2018
\nA solid dispersion of ticagrelor and Gelucire® 48/16 is prepared to increase drug solubility . The solid dispersion is converted into tablets. The formulated tablets showed improved dissolution rate compared to the market reference.
\n\n"},{"wysiwyg":"Ketkee Deshmukh, Sharda Gurram, Sunil Bambarkar, Vincent Jannin, Nabil Farah, Kavita Singh
\nCRS 2018 poster
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\nAAPS 2017
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\nThis articles describes Gelucire® 48/16 – a novel pegylated lipid excipient, and its use as a solid surfactant for solubility enhancement.
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\nThis poster describes the use of Gattefossé’s newest surfactant Gelucire® 48/16 (polyoxyl stearate type I USP-NF) and our hydrodispersible lubricant Compritol® HD5 ATO (behenoyl polyoxyl-8 glycerides USP-NF) in tablets of telmisartan, a BCS class II drug.
\nGattefossé excipients were combined with API in granulation processes and granules were compressed into tablets. Tablets of good quality and integrity were made and drug release was compared with a market reference product. Results showed improved drug dissolution in tablets made with Gelucire® 48/16 and Compritol® HD5 ATO.
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\nThis acticle describes the work undertaken in Gattefossé R&D labs (St Priest) to develop lipid formulations for low to medium lipophilicity API: piroxicam, nifedipine and curcurmin and evaluate the effect of in-vitro digestion on the solubilizing capacity of the formulations.
\n\nFormulation of a self-emulsifying lipid formulation of curcumin
\nVincent Jannin, Camille Dumont, Hamza Benhaddou, Stéphanie Chevrier, Yann Chavant, Christophe Voutsinas, Frédéric Demarne
\nAAPS 2014
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\nV. JANNIN, M. DI CUIA, S. CHEVRIER, A. FAURE, Y. CHAVANT, C. VOUTSINAS, F. DEMARNE
\nAAPS 2012
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\n\n
Advantages of lipid excipients in hot melt extrusion:
\nRange of functional excipients for extrusion:
\n\n
In a collaborative study with the University of Austin, Gattefossé investigated hot melt extrusion using polyvinylpyrrolidone (PVP) as the polymer and Compritol® 888 ATO as the plasticizer and sustained-release agent. The study showed that Compritol® improves the processability of PVP dispersions, reducing extrusion torque and increasing yield.
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EnergiNius® protège les cellules de la peau de la lumière visible artificielle émise par les écrans, un stress environnemental additionnel induit par notre mode de vie moderne.
\nFortement renforcée, la peau est visiblement ravivée et les signes de fatigue disparaissent pour un teint plus lumineux et éclatant.
\n","use_level":"1%","naturalite":"Certifié COSMOS\n
Watch the video to get a comprehensive overview of EnergiNius®:
\n
For the first time, the screen emitted artifical visible light (AVL) has been precisely characterized and Gattefossé has developed unique equipment accurately recreating the light emitted by screens.
\n","img":{"id":9021,"alt":"EnergiNius Gattefossé","title":"","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2018/04/1.jpg"},"video":""},{"content":"This in-depth study has demonstrated that screen emitted light acts as an additional environmental stress with detrimental effects:
\nEnergiNius® helps skin cells fight the deleterious effect of AVL. Its efficacy has been demonstrated at both genomic and cellular levels:
\nTested in vivo by over 200 panelists
\nThe major annual gathering of cosmetic industry professionals, in-cosmetics Global will be held in London on April 4th, 5th and 6th, 2017.
Gattefossé will be present at booth H40.
\nOver these three days, you will be able to meet our experts and discover our brand new thematic beauty concept called Show True Emotions. This concept gathers several solutions aiming at rejuvenate the skin and reduct the expression lines that may reveal misleading emotions.
\nOur new active ingredient, Gatuline® Link n Lift, targeting the eye contour, will be launched during the show and has been shortlisted for the Innovation Zone Best Ingredient Award.
\nThe show will also give us the opportunity to present the new clinical substantiation study of Gatuline® Expression AF, which helps smooth the skin around the lips.
\nIn addition, 5 new formulations including these ingredients will be exhibited on our booth : the Gattefossé application laboratories have worked on five emotions reinvented with innovative textures.
\n\n
• 1 new active launched: Gatuline® Link n Lift
\n• 1 new substantiated active: Gatuline® Expression AF
\n• 5 new formulations: innovative textures to match emotions
\n
To receive free admission to in-cosmetics London, remember to pre-register.
\nGattefossé Booth H40
\nin-cosmetics London
\n4 – 6 April 2017
\n","link_all_news":"https://www.gattefosse.com/corporate-news-social/news-social/","component":"PageNewsCos","thumbnail":{"id":4369,"alt":"","title":"show-true-emotions-thumbnail","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/05/show-true-emotions-thumbnail.jpg","width":1390,"height":1236,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/05/show-true-emotions-thumbnail-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/05/show-true-emotions-thumbnail-300x267.jpg","medium-width":300,"medium-height":267,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/05/show-true-emotions-thumbnail-768x683.jpg","medium_large-width":474,"medium_large-height":422,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/05/show-true-emotions-thumbnail-1024x911.jpg","large-width":474,"large-height":422,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/05/show-true-emotions-thumbnail-672x372.jpg","post-thumbnail-width":672,"post-thumbnail-height":372,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/05/show-true-emotions-thumbnail-1038x576.jpg","twentyfourteen-full-width-width":1038,"twentyfourteen-full-width-height":576}}},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/1836"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=1836"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/1836/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=1836"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=1836"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=1836"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"publications-on-gels-creams-and-semi-solid-forms":{"id":12408,"date":"2019-02-18T09:27:14","date_gmt":"2019-02-18T07:27:14","guid":{"rendered":"https://www.gattefosse.com/?page_id=12408"},"modified":"2019-07-30T15:40:04","modified_gmt":"2019-07-30T13:40:04","slug":"publications-on-gels-creams-and-semi-solid-forms","status":"publish","type":"page","link":"https://www.gattefosse.com/pharmaceuticals-special-content/publications-on-gels-creams-and-semi-solid-forms/","title":{"rendered":"Publications on gels creams and semi solid forms"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"publications-on-gels-creams-and-semi-solid-forms| Gattefossé","_yoast_wpseo_metadesc":"Find out Gattefossé Publications on gels creams and semi solid forms"},"categories":[36],"tags":[],"acf":{"component":"PageSpecialContentPharma","title":"Publications on gels creams and semi solid forms","introduction":"List of Gattefossé publications on gels, creams and semi-solid forms","":false,"content":[{"wysiwyg":"
[Gels, creams, semi-solid forms: from their development to their registration]
\nE. Beyssac, V. Boudy, E. Dauphin-Chanard, S. Delehouzé, L. Frances, B. Gos, C. Lacaze, V. Laffineur, A. Mestres, I. Ribeiro Dos Santos, X. Thomas and N. Zeng
\nSTP Pharma Pratiques – September October 2018 – 28(5) 181-250 – ISSN 1157-1497
\nThe SFSTP commission on topical dosage forms published an article reviewing all the steps for their development to registration.
\nInterestingly this article is both in French and English languages.
\n\nIntroduction
\nI Definition of a semi-solid
\n
II Tests and studies applicable in evaluation of semi-solid forms from development up to the phase of routine use
\n
2.1 Regulatory requirements
\n 2.2 Relevant tests in development
\n 2.2.1 Conventional characterization tests
\n 2.2.2 Characterization tests specified to evaluate performance of the formulation
\n 2.2.3 Additional characterization tests specified to evaluate performance of the formulation
III QbD approach related to the formulation
\n
3.1 Different elements of the QbD
\n 3.2 When to set up QbD ?
\n 3.3 Definition of QTPP
\n 3.4 CQAs toward evaluation of risks of process
\n 3.5 Example of CMAs studied in case of a semi-solid formulation
\n 3.6 Example of CPPs studied in case of a semi-solid formulation
Conclusion
\n IV Conclusions and perspectives
A non-ionic pure surfactant for lipid-based formulation to solubilize and increase oral bioavailability of poorly soluble API. Forms micellar solution in aqueous media.
\n","names_kv":[{"keys":"USP NF Name","value":"Polyoxyl-32 stearate (type I) NF
\n"},{"keys":"EP Name","value":"Macrogol-32 stearate (type I) EP
\n"},{"keys":"UNII Code (FDA)","value":"33GX5WQC0M
\n"},{"keys":"Preferred Substance Name (FDA)","value":"PEG-32 STEARATE
\n"},{"keys":"Handbook of Pharmaceutical Excipients","value":"Polyoxylethylene stearates
\n"},{"keys":"Chemical description","value":"Consists of PEG-32 (MW 1500) esters of palmitic (C16) and stearic (C18) acids
\n"}],"key_characteristics_kv":[{"keys":"Product form","value":"Pellets
\n"},{"keys":"Melting range (°C)","value":"46-50
\n"},{"keys":"HLB","value":"12
\n"},{"keys":"CMC (mg/L, 25°C)","value":"153 ± 31
\n"}],"main_functionalities":"Solubilizer for low log P APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into micellar solution—LFCS Type IV. Use in melt processes (granulation, extrusion), granulation, and compression. Wetting agent. Safety of use is inferred by precedence of use in approved pharmaceutical products.
\n","main_formulation_technologies":"Self-emulsifying lipid formulation for oral applications. Melt processes: granulation, extrusion, capsule molding, and compression. Wet granulation and compression.
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for Optimizing Texture and Sensorial Experience"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Excipients for optimizing texture of topical dosage forms | Gattefossé","_yoast_wpseo_metadesc":"Discover our range of excipients to improve texture and sensorial properties of topical dosage forms and positively impact patient experience."},"categories":[49],"tags":[],"acf":{"component":"PageGenericContentPharma","title":"Excipients for Optimizing Texture and Sensorial Experience","content":"Improvement of topical dosage form texture and sensorial properties is an increasingly common formulation objective:
\nSensorial mapping evaluates product’ aspects during application and absorption. We have developed a database of prototype formulations with different textures and sensorial profiles. This helps our customers select formulations with excellent texture and sensorial properties. Dermacare is a collection of simple and effective prototypes of creams, emulgels, and lotions with optimized texture and sensorial properties. Our database also includes formulations for foams, sprays, microemulsions, and gels. Contact Gattefossé for our Dermacare guidelines.
Multifunctional ingredients that meet desired customer claim and ease the formulation process are becoming more and more in demand.
\nThe specific technology behing Acticire® MB makes it a distinct, multifunctional ingredient with several unique applications.
\n","use_level":"1-5%","naturalite":"COSMOS approvedA 100% natural texturizing agent based on a complex of 3 functionalized waxes:
\nActicire® MB is a multifunctional ingredient with several unique applications. This video illustrates how Acticire® MB can be used to introduce water based ingredients into anhydrous formulations.
\nIn this example, an hydrophilic dye is incorporated into the water phase to show how it is well dispersed in a lipstick with Acticire® MB.
\nThese three waxes have been transesterified in the presence of vegetable polyglycerin, rendering them more compatible and stabler in emulsion, and confering new sensorial qualities and characteristics:
\nActicire® MB brings three different and distinctive benefits to cosmetic formulations:
\n\n
Our sensory panel brings together over a dozen trained staff members, both men and women. They test new formulations approximately twice a week. The assessments are carried out using specific protocols and standardized procedures, and the results are statistically analyzed.
Tests cover vision and touch, and they evaluate the following criteria:
\nInitial touch \n
\n \n
| \nDuring application\n
| \nAfter absorption\n
| \n
\n\n
\n
This sensorial map shows the results with cream formulations formulated with different Gattefossé pharmaceutical-grade emulsifiers. It enables direct and visual comparison and can help to select the emulsifier or appropriate prototype formulation.
\nClick on the image to enlarge.
\n\n
For more information on how to develop formulas for optimized texture and sensory properties, please see our topical formulation section.
\n\n
\n
\n
\n"}]},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/3654"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=3654"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/3654/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=3654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=3654"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=3654"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"the-nades-technology-2":{"id":18608,"date":"2020-04-14T15:47:48","date_gmt":"2020-04-14T13:47:48","guid":{"rendered":"https://www.gattefosse.com/?page_id=18608"},"modified":"2021-05-19T22:19:29","modified_gmt":"2021-05-19T20:19:29","slug":"the-nades-technology-2","status":"publish","type":"page","link":"https://www.gattefosse.com/fr/personal-care-trend/the-nades-technology-2/","title":{"rendered":"Opening new horizons for natural cosmetics: The NaDES technology"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":28,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Using the NaDES technology for natural active ingredients","_yoast_wpseo_metadesc":"The NaDES technology is a new solution, adopted by Gattefossé, to create new, 100% natural, and highly functional active ingredients."},"categories":[56],"tags":[],"acf":{"component":"PageGenericContentCos","title":"The NaDES Technology","content":"
This new category of green solvents is directly inspired by botanicals and the way in which metabolites are solubilized inside the plant – through eutectic combinations of simple chemicals such as sugars, nitrogen compounds, and organic acids.
\n Working with researchers from Leiden University, Gattefossé has developed and patented several natural eutectic solvents, perfectly adapted for the extraction of cosmetic active ingredients (1). This exciting class of solvents uses all-natural components such as sugars, polyols, amino acids.
\n
A NaDES can be defined as a eutectic mixture formed by a combination of natural compounds with specific molar ratio. It melts at a single, sharp unique temperature named the “eutectic point” (the lowest melting point for a specific composition) and is characterized by a supramolecular structure.
\nThis homogenous liquid is stable once the eutectic point is reached, making possible its use for extraction applications.
\n\n
Through an ambitious research program, Gattefossé revealed many advantages linked to this extraction technology.
\nCompletely natural, NaDES combinations benefits from a perfect affinity with plants enabling to reach high extraction potential. The botanical extracts obtained unveil unique phytochemical signature, and performance that would be impossible to reach using conventional solvents.
\n Gattefossé thus makes the most of this technology to rediscover well known plants in cosmetics (Calendula, Mallow, Rose, Horse Chesnut…), and opens therefore new fields of possibility.
\n 2 applications patents have already been granted (2).
\n
\n From plants and solvents selection to industrialization stage, we master in house all the steps of the development and manufacturing process.
\n Our research teams are committed to continue exploring the potential of NaDES.
\n Our research perspectives are still wide, and the coming years will surely see the rise of new NaDES active ingredients.
\n Natural, non-toxic and efficient at low temperatures, the NaDES technology is perfectly aligned with Gattefossé commitments to provide high-performance sustainable active ingredients.
Want to know more about the NaDES technology? Do not hesitate to contact your local sales representative.
\n\n (1) Patent FR3036618B1, GATTEFOSSE SAS, CAPRIN B, CHARTON V, DEMARNE F: Vegetable extracts for cosmetics, solvents and methods for obtaining same
\n (2) Patent FR3053890B1, US10363212B2, GATTEFOSSE SAS, CHARTON V, CAPRIN B, BECHETOILE N: Aesculus Hippocastanum extract
\n (2) Patent FR3067939A1, GATTEFOSSE SAS, BECHETOILE N, LOPIS-PRESLE S: Extract of Whitania Somnifera to fight against the harmful effects of visible light on skin
Air pollutants disrupt the natural balance of the epidermis and lead to oxidation, cutaneous inflammation and irritation (up to sensitization). The hydrolipid film is altered and the barrier reduced. As a result, the skin becomes sensitive, with a dull complexion, greasy and dehydrated.
\nGood microcirculation is crucial to help the skin fight pollution and improve the condition of sensitive skin: it induces a better oxygenation and nutrition, and thus a visible radiant skin.
\n\n
\n
The efficacy of Gatuline® Radiance on skin microcirculation is the direct result of the extracellular release of nitric oxide (NO) from endothelial cells. By stimulating this physiological pathway, Gatuline® Radiance enables the relaxation of the microvessel walls, a phenomenon called vasodilation. Due to its stimulating effect on microcirculation, Gatuline® Radiance contributes to the nutrition of the support tissues of the skin. The face is revitalized and acquires a healthy glow, luminosity and a more even appearance.
\n\n
\n
A new clinical study has demonstrated that Gatuline® Radiance visibly enhanced skin brightness even under heavy pollution. Gatuline® Radiance was tested during 4 weeks, at 3% in an emulsion. The study took place in Wuhan, China (Air Quality Index was measured to confirm highly polluted environment). Results clearly show that Gatuline® Radiance induces a better oxygenation and nutrition, thus a visible radiant skin. The skin is soothed, its vitality is improved, with less visible pores.
\n\n
\n
Panelists have confirmed these results. They feel their skin reacts less to external aggressions.
\nMarch 20, 2023 – Gattefossé unveils Emulium® Dermolea MB, the sensitive skin shield
January, 30, 2023 – Inspiration 2023, discover the new collection of formulations by Gattefossé
December, 1, 2022 – Gattefossé wins the INPI Trophies 2022 award in the export category
\nNovember, 24, 2022 – Gattefossé unveils its new collection of suncare formulas
September, 20, 2022 – Two new ingredients labelled ERI 360° for Gattefossé
September, 7, 2022 – Gattefossé & CTIBiotech develop world’s first Bioimpedance 3D Bioprinted skin chips to link cosmetics lab testing to humans
May, 31, 2022 – Gattefossé strengthens its international footprint and breaks ground on its production site in Texas
April, 6, 2022 – Gattefossé receives an Innovation Award for Solastemis™
April, 4, 2022 – Gattefossé unveils Solastemis™, the next step towards photoprotection
February, 9, 2022 – Gattefossé strengthens its CSR approach and reaches two major milestones
January, 11, 2022 – Inspiration 2022, discover the new collection of formulations by Gattefossé
\n
October 28, 2021 – Gattefossé expands its offer with the launch of three new pharmaceutical excipients
July 12, 2021 – Gattefossé strengthens its strategy of developing responsible ingredients with 3 products labeled ERI 360°
June 8, 2021 – Ségolène Moyrand-Gros appointed President of the Gattefossé Group
April 1, 2021 – With EleVastinTM, Gattefossé fights gravity-induced skin sagging
March 15, 2021 – Gattefossé and BioMeca jointly developed a model of 3D dermal microtissue to study elastic properties in vitro
January 9, 2021 – A new 2021 edition for Gattefossé’s tool INSPIRATION
\n
December 18, 2020 – Gattefossé continues its international development and builds a production site in Texas
November 20, 2020 – Gattefossé launches its corporate website in Chinese
October 15, 2020 – Gattefossé releases new susbtantiation data on the resolution of inflammation
October 6, 2020 – Gattefossé presents Emulium® Dolcea MB, its latest natural O/W emulsifier
\n\nApril 9, 2020 – COVID-19: Gattefossé takes measures and continues to be operational
February 12, 2020 – Gattefossé comes into the microbiome discussion with a new study on its O/W emulsifier Emulium® Mellifera MB
January 9, 2020 – COSMET’AGORA 2020, a new edition for Gattefossé’s tool INSPIRATION
\n
October 31st, 2019 – Gattefossé reveals new clinical data for its natural origin active Gatuline® In-Tense MB
October 28th, 2019 – Gattefossé announces the release of Addiactive magazine in English
April 15th, 2019 – GOLD rating for Gattefossé on EcoVadis
April 3rd, 2019 – Gattefossé receives the Gold Innovation award for Emulium® Illustro
March 9th, 2019 – Definicire™ receives PCHi Fountain Awards 2019 in China
February 19th, 2019 – Gattefossé launches its new W/O emulsifier at in-cosmetics global
\n
December 17th, 2018 – COSMET’AGORA 2019, a new edition for Gattefossé’s tool INSPIRATION
October 23, 2018 – Gattefossé North America announces the recipient of the 2018 Award for Excellence
September 19th, 2018 – Gattefossé launches its first hair care
\n ingredient at in-cosmetics Latin America
July 10th 2018 – Gattefossé renews its ISO 9001 certification and achieves the 2015 version
June 5th 2018 – Official launch of ERI 360° Label
\n
April 10th 2018 – Meet the #ConnectedGenerations at in-cosmetics global 2018
\n
March 29th 2018 – EnergiNius™: Gattefossé new launch at in-cosmetics Amsterdam 2018
\n
February 20th 2018 – Gattefossé Asia Pacific achieves ISO9001: 2015 certification
\n
January 25th 2018 – Gattefossé launches INSPIRATION tool
\n
November 10th 2017 – Gattefossé North America announces the recipient of the 2017 Award for Excellence
\n
November 6th 2017 – SIO-ADM, Gattefossé partner to bring USP/NF grade highly refined oils to North America
\n
October 18th 2017 – GATTEFOSSÉ and CYTOO join forces to investigate the biological effects of screen-emitted light on skin
\n
September 20th 2017 – The Gattefossé foundation supports two Health establishments
\n
July 28th 2017- Gattefossé Canada and Connect Chemicals announce distribution agreement
\n
April 26th 2017- Inauguration of our North America Technical Center of Excellence
Contact us to receive the Press Dossier
\n\n\n\n
\n
March 29th 2017 – Show true emotions at in-cosmetics London: two ingredients targeting the eye and lip contours
\n
March 21th 2017 – Gattefossé Foundation promotes the training of healthcare personnel in the use of Madagascan essential oils in Madagascar
\n
March 6th 2017 – Gattefossé certified RSPO Mass Balance
\n
February 8th 2017 – New launch: Gatuline® Link n Lift – Redesign the eye contour
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\nDepending on references:
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Osborne and Jasmine Musakhanian
\nAAPS PharmSciTech (# 2018)
\n DOI: 10.1208/s12249-018-1196-8
In this critical article, the authors have reviewed numerous studies in order to elucidate the mechanism of action of the highly purified diethylene glycol monoethyl ether TRANSCUTOL® on skin penetration and permeation.
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\n\n"},{"wysiwyg":"Shen M, Liu C, Wan X, Farah N, Fang L.
\nDrug Dev Ind Pharm. 2018 Oct;44(10):1642-1649. doi: 10.1080/03639045.2018.1483391. Epub 2018 Jul 2.
\nA patch for transdermal delivery of daphnetin was developped using Transcutol® P as permeation enhancer.
\nThe study showed:
\nNovember 2015
\nThis white paper describes Transcutol®, the highest purified pharmaceutical grade of Diethylene Glyceryl monoEthylEther (DEGEE).
Scientific publications asserting the safety of Transcutol® are listed to highlight the non-skin irritant property of Transcutol®. Moreover, solvent properties of Transcutol® are described and solubility data in different solvents are given to illustrate the remarkable solvent capacity of Transcutol®.
\nThis exceptional safety and solvent property make Transcutol® an ideal chemical penetration enhancer for topical formulations, where efficiency and non skin irritancy are key success factors. Examples of commercial uses of DEGEE are cited to illustrate the versatility of use of this excipient in many different topical dosage forms. Practical information is also given for the formulation of Transcutol® in many topical dosage forms.
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• Drug release is a function of diffusion, which enables simple product design and offers both straightforward modulation of drug release and high reproducibility. • Tablets are biopharmaceutically robust as the lipid matrix is not sensitive to physiological variations (e.g., pH, digestive processes, alcohol level). • Agents are suitable for a wide range of processing techniques, including direct compression, granulation, melt coating, hot melt extrusion, and capsule molding.
\nSome APIs present poor organoleptic properties; therefore, taste or odor need to be masked. Others are sensitive to water, oxidation, or temperature and need to be protected to maintain stability. Certain lipid excipients are used in melt processes to effectively protect the API from degradation or mask taste and odor.
\n\n
• thermoplastic behavior conducive to processes used (high shear coating, hot melt coating, granulation, extrusion, and capsule molding) • solvent-free process • chemically inert—highly compatible with other excipients in the formulation • plastic deformation for high resistance to compaction • lipid coating that does not impact bioavailability
In 1966, Gattefossé pioneered the first event to exchange on galenical formulations with the institution of the Journées Galéniques of Saint Remy de Provence. Throughout the years numerous subjects have been addressed by internationally recognized researchers, academic and industrial, always sharing their latest findings for the benefit of the whole pharmaceutical community.
\nEach year the proceedings of the meetings have been published in a Bulletin Technique, progressively building a rich collection. In a long tradition of sharing knowledge and for the 50th anniversary of Les Journées Galéniques, the Gattefossé Foundation is pleased to make the entire collection now available.
\nWe invite you to open the doors of this unique and eclectic library to benefit from this knowledge of pharmaceutical science, formulation and drug delivery.
\n\n
Bulletin Technique 2018 – Lipids and polymers in pharmaceutical technology Lifelong companions
Published as an open access article in International Journal of Pharmaceutics 558 (2019) 128-142
\n
In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, stabilizers, solubilizers, permeation enhancers and transfection agents. Focusing on selected applications, which were discussed at the Biennial Scientific Meeting of the Gattefossé Foundation 2018, this manuscript recapitulates the fundamental roles of these two important classes of excipients, either employed alone or in combination, and provides insight on their functional properties in various types of drug formulations. Emphasis is placed on oral formulations for the administration of active pharmaceutical ingredients with low aqueous solubilities or poor permeation properties. Additionally, this review article covers the use of lipids and polymers in the design of colloidal injectable delivery systems, and as substrates in additive manufacturing technologies for the production of tailor-made dosage forms.
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Bulletin Technique 2015 – It’s life Jim but not as we’d like it: navigating beyond the rule-of-5
The 49th Journées Galéniques gathered together leading academics and industrial scientists from around the world to provide a contemporary and updated understanding of the challenges and opportunities in drug development for molecules which are outside the traditional ‘rule-of-5’ drug space.
\nIn this 108th Edition of the Bulletin Technique you will find the abstracts and information about the presenters. However the majority of full articles have been published in the Advanced Drug Delivery Reviews entitled ‘Understanding the challenges of beyond the rule of 5 compounds: Volume 101 June 1, 2016.
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Bulletin Technique 2014 – It’s just mucosa, get over it…
This year’s edition is essential reading for anyone working in the delivery of therapeutic molecules across thin or thick mucosal barriers. It contains insight and foresight from leading experts in drug delivery science from around the world.
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Building bridges between oral and topical drug delivery, between health and beauty to reinvent tomorrow’s medicines.
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Bulletin Technique 2012 – Melt techniques in solid dosage forms & GI modeling in the spotlight
Exploring the potential of melt techniques to produce solid dosage forms and the modelization of drug release in the gastrointestinal tract.
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Bulletin Technique 2011 – Supersaturating drug delivery systems
An in depth exploration of the use of supersaturation as drug delivery systems.
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The 44th annual Conference of the Journées Galéniques (June 2010) was devoted to aromatherapy, coinciding with the 130th anniversary of the Gattefossé company and a tribute to René-Maurice Gattefossé, a pioneer of aromatherapy as we know it. This special conference focused on the potential of aromatherapy as a complementary therapy as a means of achieving improved health equilibrium.
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Bulletin Technique 2009 – Paediatric drug development tackling current and future challenges
A comprehensive overview of biological, clinical and formulation challenges associated with paediatric drug development
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Bulletin Technique 2008 – Nanotechnology for impoving drug delivery across biologicals barriers
Description of the latest technologies available to produce nanoparticles and illustration of their potential in specific drug delivery across mucosalmembranes.
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Complete overview of lipid excipients for efficient oral drug delivery systems
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Bulletin Technique 2006 – 40th anniversary: Influence of lipid excipients on oral drug absorption
Unveiling the mechanism of lipids in drug absorption and giving clues for efficient lipid based formulation
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Bulletin Technique 2005 – Drug candidate optimization, formulation and early development
Focusing on drug candidate to better understang how to shorten the time between their selection and the development of the medicine
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Bulletin Technique 2004 – Sustained release formulation with lipid based excipient
Sustained release formulation with lipid-based excipients, from the academic perspective to actual industrial applications
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Bulletin Technique 2003 – Challenge in drug delivery for the new millenium
Depicting new drug delivery systems and their promising future in personalized medicines
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Bulletin Technique 2002 – Human skin, the medium of touch
A complete update on skin structure and on technologies for topical and transdermal drug delivery to envisage new developments
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Bulletin Technique 2001 – Oral drug absorption: a renaissance
Understanding the role of intestinal epithelial cells in absorption and the influence of lipids for better formulation of oral drug delivery systems
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Bulletin Technique 2000 – Frontiers in biopharmacy
Understanding the pharmacokinetics of the drug molecules, assessing their potential using latest cell culture methods and other biopharmaceutical tools
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Bulletin Technique 1999 – Recent advances in the formulation and development of poorly-soluble drugs
Using lipid to formulate poorly soluble drugs, keys to successful formulations
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Bulletin Technique 1998 – Strategy for delivering insoluble compounds in lipid formulations
Optimizing the drug candidates for lipid-based formulations and using predictive studies for quicker formulation development
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Bulletin Technique 1997 – New lipidic systems enhancing the bioavailability of problem drugs
Understanding the rationale behind lipidic systems to formulate challenging drugs
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Bulletin Technique 1996 – Semi-solid formulations and oral absorption enhancement
Filling hard gelatin capsules with semi-solid lipid systems for oral drug delivery: all the facettes of this art are described
\n\n","box_links":[],"useful_links":[],"content_not_translated":true,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/5073"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=5073"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/5073/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=5073"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=5073"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=5073"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"pigment-empowered-2":{"id":13260,"date":"2019-04-26T19:25:35","date_gmt":"2019-04-26T17:25:35","guid":{"rendered":"https://www.gattefosse.com/?page_id=13260"},"modified":"2019-05-02T17:08:05","modified_gmt":"2019-05-02T15:08:05","slug":"pigment-empowered-2","status":"publish","type":"page","link":"https://www.gattefosse.com/personal-care-content/pigment-empowered-2/","title":{"rendered":"Pigment Empowered"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":""},"categories":[50],"tags":[],"acf":{"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false,"component":"PageGenericContentCos","title":"Pigment Empowered","content":"
Since antiquity, women have been wearing makeup to transform their appearance. From the kohl of ancient Egypt to the powdered chalk of old Greece to the greasy blushes of the Victorian era, while beauty ideals have changed remarkably with the years, makeup has been an integral part in the lives of women throughout history.
\nEven in recent years, we’ve seen a marked shift in beauty ideals from bold, powerful makeup to the more subtle and natural look that is preferred by women today. To understand the shift in attitudes towards complexion makeup, Gattefossé conducted a global survey of over 1200 women in Korea, France, and the US in which we asked them about their makeup habits and perceptions.
\n\n
Overall, the women felt that foundation makes them feel beautiful, allows them to hide flaws, and can be comfortable to wear. However, especially in South Korea, they also believe that it can contain ingredients that are bad for the skin, and can cause pimples.
\nIn France and the US, women have difficulty finding the right shade when purchasing foundations, which has led to the movement for more inclusive shades and customizable, personalized products that is currently emerging.
\nWhen asked about natural complexion makeup, we saw that consumers in all regions believe that natural products are better for them, better for the environment, and a good alternative to conventional makeup, but that interest in natural makeup was still low due to perceptions of poor performance, expense, and lack of availability.
\n\n
Emulium® Illustro has been designed as a solution to the natural makeup dilemma. This high-performance, vegan and natural W/O emulsifier was specifically developed to work with pigments to deliver the benefits customers expect from natural complexion makeup.
\nEmulium® Illustro is the first emulsifier developed as a direct collaboration between the Gattefossé R&D and application laboratories. At each step of the development process, the application lab worked with the ingredient to ensure that the end result is high-performance, easy to formulate, and brings a unique sensory imprint to makeup formulations.
\nThe resulting ingredient is designed to work well with pigments, film formers, pearls, emollients, UV filters, and more. It can create textures that range from ultra-fluid serums to sticks, it is globally approved, and it brings unique sensoriality not only to makeup but also to sun care and skin care formulations.
\n\n
Two clinical studies have been conducted on Emulium® Illustro. The first substantiates the “non-comedogenic” claim for the product. In this study, 20 female volunteers with oily skin, all regular users of silicone foundations, used a foundation containing Emulium® Illustro once a day for 27 days. At the end of the study, a dermatologist found no statistically significant increase in retentional and inflammatory signs, validating the claim “non-comedogenic” for Emulium® Illustro.
\nIn the second study, 34 female volunteers, all regular users of silicone foundations, replaced their normal foundation with an Emulium® Illustro foundation for 27 days. Foundation performance and skin quality were evaluated. At the end of the study, the women were satisfied with the performance of the foundation, and interestingly, they saw in improvement in overall skin quality.
\n\n
Lastly, the women were asked at the end of the study if they would like to continue using the foundation beyond the end of the study. Without knowing the formula composition, 74% of women said they would like to continue using the foundation. When they were then informed of the natural, PEG-free, silicone-free composition however, this number increased to an astounding 91% of panelists who were willing to abandon their traditional silicone foundation for the product tested. This interest really highlights the interest of the market in high-performing natural makeup formulations.
\n![]() | \nThe industry has recognized both the need for better natural solutions for complexion makeup and the innovation and quality of Emulium® Illustro by awarding this ingredient the Gold prize for the 2019 In-Cosmetics Global Innovation Zone Best Functional Ingredient Award. | \n
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If you’re interested in the results of our global consumer perception study, stay tuned here over the next 3 months as we release the details about the ways consumer think about complexion makeup region by region.
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Discover Dermacare and learn how our pharmaceutical grade emulsifiers can be used to create an exciting range of topical dosage forms with excellent texture and sensorial properties that will delight patients.
\n\n
\n
An incredible texture for this balm, well-adapted for massage.
The thickness is brought by a subtle combination of Compritol® 888 Pellets, Geleol™ Mono and Diglecerides NF and hydrogenated castor oil.
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The overwhelming message in advertising and media has been that youth is the holy grail. However, today the message is changing, to better reflect the reality of aging and beauty of life.
\n\n
\n
According to recent articles, the way you perceive aging can actually influence how you age. “Positive and negative attitudes can affect your health behaviorally, psychologically, and even biologically. Being ‘pro-aging’, or satisfied with your own aging, can make you adopt healthier behaviors, feel in control of how you age, and even heighten your immune system.”1
\n\n
\n
We are beginning to see this shift towards pro-aging make its way into beauty and cosmetics. Baby boomers, as they age, are realizing that aging can’t be fought forever and are instead embracing the changes that come with time. And cosmetics companies are moving with the mindset of their customers.
\n\n
\n
Pro-aging doesn’t mean a rejection of cosmetics, but rather a more targeted selection towards products designed to enhance the appearance at any age, instead of hiding and fighting every symptom of aging. The philosophy behind pro-aging is to remove all “anti” claims and replace them with more positive imagery. “Pro-age products are more about nourishing and moisturizing the skin, enhancing features rather than trying to fill them in or mask them.”2
\n\n
\n
Gattefossé offers ingredients that meet the demands of the pro-aging trend.
\n\n
Download the formula sheets in the “Related documents” box in the right column.
\n\n
\n","box_links":[],"useful_links":[{"text_link":"5 powerful benefits of 'pro-aging' thinking (CNN.com)","link":false,"external_link":"http://www.cnn.com/2015/01/02/health/age-self-fulfilling-prophecy/"},{"text_link":"Anti-Aging Products Dominate the Cosmetics Industry, but Will the “Pro Age Revolution” Challenge That? 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Kappa MB","tagline":"Natural sensuality","description_product_finder":"","introduction":"
Gattefossé has developed Emulium® Kappa MB to answer formulators’ need for a multifunctional PEG-free emulsifier of natural origin that yields stable emulsions; offers the added value of greater activity; and creates a unique sensorial identity.
\nOil-in-water emulsions based on Emulium® Kappa MB are very glossy and have a rich and luxurious feel. They are easy to apply, have a long play time, create a sensation of comfort, are softly textured (comparable to silicone elastomers), and exert a remarkable, lasting cushion effect—for baby-soft, replumed skin.
\n","use_level":"2.5-6%","naturalite":"ECOCERT approvedPEG-free emulsifier derived from natural waxes:
\nSensory profile:
\nProperties
\nThe skin automatically responds to attacks with inflammation, a controlled reaction that is part of a natural defense and repair process. In today’s environment, the skin is constantly under assault by pollution and the environment. These conditions can trigger the inflammatory reaction in an uncontrollable manner with harsh effects. It’s no wonder that 62% of women say they have sensitive skin. Sensitive skin is an uncomfortable condition associated with redness, itching, flaking, and stinging. Skin gets drier with age; so, as dryness and sensitivity are often linked, the discomfort only worsens over time. Gatuline® Derma Sensitive is a natural active designed to comfort and protect sensitive skin. This oily extract of caper buds helps reduce clinical signs of inflammation and soothe sensitive skin.
\n","use_level":"2%","naturalite":"ECOCERT/COSMOS approvedGatuline® Derma Sensitive applies gemmotherapy, an approach that turns to the highly energetic substances contained in the embryonic plant tissues of buds and seeds. It is extracted from the buds of caper flowers, sourced in the Mediterranean region. This all-natural; non-GMO; preservative-, pesticide-, and allergen-free active is approved for use in natural formulations certified by Ecocert. Preservative free.
\nIn vitro and in vivo tests prove Gatuline® Derma Sensitive
\nThe North American region is a leading market for pharmaceuticals and personal care with important local production, consumption and a major influence on global trends. Within this favorable context, Gattefossé North America has enjoyed continuous growth in its business activity since its creation in 1982.
\nTo expand its presence in the region, the Gattefossé Group has decided to establish its fourth Technical Center of Excellence in Paramus, New Jersey. Mr. Jacques Moyrand, Gattefossé Group Chairman, Mr. Olivier Midler, Gattefossé Group CEO and Mr. Eric Brun, President and CEO of Gattefossé USA and Canada, will inaugurate the North America Technical Center of Excellence on Wednesday, April 26th 2017. This center brings together pharmaceutical and personal care application laboratories in a 5,300 ft² (492 m²) space with state-of-the-art equipments.
\nThe technical team will offer an essential interface with both pharmaceutical and personal care customers throughout North America by providing formulation troubleshooting, inspiration and technical support.
\nFor pharmaceuticals, high priority will be given to oral bioavailability enhancement and modified release applications. For personal care, the laboratory will develop specific formulas to answer local needs and to capture local trends.“The latest sign of our investment in this strategic market is the creation of the Gattefossé North America Technical Center of Excellence. These state-of-the-art application laboratories located in Paramus, New Jersey, will ensure our customers responsive service adapted to their market”.
\nEric Brun, President and CEO of Gattefossé USA and Canada
\n\n
\n\n
The USA and Canadian affiliates of Gattefossé (created respectively in 1982 and 1997) were established to provide local service and support to the.pharmaceutical and personal care industries in North America. Since its creation, Gattefossé North America has enjoyed continuous growth, expanding its presence as a provider of innovative solutions involving performance ingredients.
\nUnder the leadership of Eric Brun, Ph. D, a specialized team of professionals, including marketing, customer service, supply chain, quality, and technical support, is fully committed to servicing customers from the corporate offices in Paramus, NJ, Toronto, ON and Montreal, QC. Local service is also provided by long-term partners in the US Midwest and West Coast, as well as Mexico.
\nToday, Gattefossé has 34 employees and 3 offices in North America as well as 3 warehouses in Edison (NJ), La Mirada (CA) and Toronto (Canada).
\n","link_all_news":"https://www.gattefosse.com/corporate-news-social/news-social/","component":"PageNewsCorporate","thumbnail":{"id":2499,"alt":"Application laboratories Gattefossé USA","title":"labo-usa-thumbnail","caption":"","description":"","mime_type":"image/jpeg","url":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/labo-USA-thumbnail.jpg","width":262,"height":220,"sizes":{"thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/labo-USA-thumbnail-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/labo-USA-thumbnail.jpg","medium-width":262,"medium-height":220,"medium_large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/labo-USA-thumbnail.jpg","medium_large-width":262,"medium_large-height":220,"large":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/labo-USA-thumbnail.jpg","large-width":262,"large-height":220,"post-thumbnail":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/labo-USA-thumbnail.jpg","post-thumbnail-width":262,"post-thumbnail-height":220,"twentyfourteen-full-width":"https://www.gattefosse.com/wordpress/wp-content/uploads/2017/04/labo-USA-thumbnail.jpg","twentyfourteen-full-width-width":262,"twentyfourteen-full-width-height":220}}},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/2495"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/36"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=2495"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/2495/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=2495"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=2495"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=2495"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"gattefosse-tech-forum-2017-crs-annual-meeting":{"id":5324,"date":"2017-06-15T08:46:58","date_gmt":"2017-06-15T08:46:58","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=5324"},"modified":"2017-06-15T08:50:20","modified_gmt":"2017-06-15T08:50:20","slug":"gattefosse-tech-forum-2017-crs-annual-meeting","status":"publish","type":"page","link":"https://www.gattefosse.com/pharmaceuticals-news/gattefosse-tech-forum-2017-crs-annual-meeting/","title":{"rendered":"Gattefossé Tech Forum – 2017 CRS Annual Meeting"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":""},"categories":[44],"tags":[],"acf":{"title":"Gattefossé Tech Forum - 2017 CRS Annual Meeting: Learn about peptide delivery","description":"Our experts V. Jannin HDR and J. Musakhanian will present recent works at the CRS Annual Meeting in Boston, July 16, 2017. ","date":"15.06.17","content":"What You Should Know About Lipid-Based Formulations:
\nOral Delivery of Peptides
July 16, 2017
\n9:00-10:00 a.m.
\nConvention Center, Room E
\n
Oral administration of peptides is challenged by a number of physiological barriers including presystemic degradation by proteases, deactivation by reduced glutathione, and poor intestinal membrane permeability. Lipid formulations, notably self-emulsifying drug delivery systems (SEDDS), can successfully overcome these challenges.
\nIn an interesting series of recently published works, model peptides leuprorelin, insulin and desmopressin were formulated in SEDDS following hydrophobic ion-pairing of the peptides. The newly designed formulations facilitated payloads of >10% for peptide drugs, provided 100% protection against proteases, and reduced glutathione, and improved their intestinal permeability.
\nThis session shares the intricacies and the promising results of the aforesaid work.
\nSpeakers:
\nVincent Jannin HDR (Dir. R&D Projects)
\nJasmine Musakhanian, M.Sc. Scientific and Marketing Dir
For all registered attendees, this event is complimentary. Gattefossé will also be exhibiting at Booth 404 in the main hall.
\n\n","link_all_news":"https://www.gattefosse.com/corporate-news-social/news-social/","component":"PageNewsPharma","thumbnail":{"id":5342,"alt":"CRS Annual Meeting 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Expression AF"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":36,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Gatuline® Expression AF | Smoothing anti-wrinkle active | Gattefossé","_yoast_wpseo_metadesc":"Gatuline® Expression AF is a fast-acting ingredient that redefines both the eye and lip contours in record time and prevents expression lines."},"categories":[6],"tags":[],"acf":{"component":"PageCosmeticProduct","product_codes":[{"code":"5891"}],"bandeau_image":{"id":13758,"alt":"","title":"Gatuline 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showing perfect toothy selfie","title":"Gattefossé Gatuline Expression 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Expression AF","tagline":"Immediate smoothing","description_product_finder":"","introduction":"Expression lines (i.e., fine lines) are the result of thousands of daily involuntary microcontractions of the facial muscles. They become more visible and deeper as we age and are a real concern for people who want to maintain a youthful appearance. Gatuline® Expression effectively prevents the appearance of expression lines and visibly smooths the skin surface. This fast-acting ingredient redefines both the eye and lip contours in record time.
\n","use_level":"2-5%","naturalite":"ECOCERT/COSMOS approved","inci":"Propanediol (and) Water (and)Natural, safe, preservative-free extract of a non-GMO plant grown in a protected environment. Acmella oleracea is a plant with small yellow flowers commonly used as a spice and anesthetic agent in Madagascar, from which it is sourced. In fact, its unique numbing effect led to its popularity in cocktails and the nickname “buzz buttons.” This anesthetic effect is also what drew the attention of Gattefossé researchers. Other grade available: Gatuline® Expression (INCI : Alcohol (and) Water (and) Acmella Oleracea Extract)
\nIn vitro and in vivo tests prove Gatuline® Expression AF
\nThe typical beauty consumer applies 150 different ingredients to his or her face each and every day (Figaro, 2017). In today’s environment of increasing transparency and accountability, consumers want to know the risks they incur when they apply products to their face or body.
\nWhere “green” or “natural” used to be the key buzzwords, today we see more and more products moving to “clean beauty” where naturality is good, but safety is paramount.
\n\n
Still a recent concept in beauty, “clean” is an idea that originally began in the food industry and moved into personal care with the introduction of slow beauty, which goes beyond natural and focuses on conscious consumption. Not to be confused with “natural” or “organic”, the term “clean” refers to products formulated without so-called harmful ingredients such as parabens, phthalates, or even retinol.
\nConsume smarter, respect the environment, monitor what we use: many people today pay more attention to their well-being, but also to their impact on the planet, than ever before. Consumers are already well tuned to transparency, environmental and safety concerns when talking about food, sport, or wellness, and their increased awareness is rubbing off on their cosmetic consumption. In other words, today’s consumer wants to take back the reigns of their beauty routine and put common sense and understanding into it.
\n\n\n#cleanbeauty
\n
\n The hashtags #eatclean or #healthyeating are already widely used on Instagram, but #cleanbeauty isn’t far behind – with 813,000 posts as of July 2018.
\n
A growing segment of consumers are looking for natural beauty products – natural ingredients, claims, and labels continue to grow in prevalence and popularity. But clean goes is a similar but different direction. With a positioning that sits between ethics and safety, the target for this claim is huge, even universal – since all consumers of cosmetics want and expect safe products.
\nAnd major retailers like Sephora are jumping on board. Sephora has recently launched “clean at Sephora” which identifies certain products as being “they beauty you want, minus the ingredients you don’t”. Brands that are granted the “clean at Sephora” seal must be free from SLS, SLES, parabens, formaldehydes, phthalates, mineral oil, retinyl palmitate, oxybenzone, and more. They must also contain less than 1% of synthetic fragrances. It’s the no-no list taken to the next level.
\n\n
For all but the most knowledgeable consumers, the INCI listing remains largely indecipherable. To assist consumers in their purchasing decisions, many apps have emerged promising to decode the composition of all kinds of products from home cleansers to skin care.
\nBy scanning a product’s bar code, the consumer can have an immediate assessment of the supposed danger or safety of the product and a run-down of the controversial ingredients or allergens it contains.
\n\n
![]() | \nApps like ThinkDirty allow consumers \n to analyze ingredients and make clean \n purchasing decisions. | \n
\n
Just as Shazam lets us recognize the title of any song we hear, in one click these apps let us know if a product is good for our skin and health.
\nIt’s important to note that these apps are controversial due to the sometimes questionable scores they provide, but it’s equally important to realize that many consumers are relying on this information for clarity in what they consider a murky situation.
\n\n
The Environmental Working Group (EWG) is a non-profit organization that strives to “protect human health and the environment”. As part of these efforts, the group has created a ranking system for cosmetic products and ingredients, designed to reflect potential health hazards. The ranking system goes from 1-10 with a rating of 1-2 considered as low hazard (green).
\nThe EWG ranking has rapidly gained interest in certain markets, particularly in Asia, where the claim “EWG Green” has become increasingly important. Additionally, many companies in other markets, such as the US, are also turning to EWG as a basis for the creation of clean products and formulations.
\n\n
Gattefossé ingredients are well positioned to meet both the natural and clean beauty movements. Many of our textures and actives are both natural and EWG green, meeting the needs of both markets.
\n\n\nFor a complete list of our natural and EWG Green ingredients, click here.
\n
\n
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In this technique a microcapillary is used (75 µm section, 75 to 130 cm length) into which a laminar flow of buffer is applied. The sample (solute) is injected in this flow and spreads out axially due to the combined action of convection (red arrow) and radial (blue arrows) diffusion.
\nDetection of the equilibrium concentration profile (Taylorgram) allows to calculate the absolute molecular diffusion coefficient and hence the hydrodynamic radius of the solute molecules.
\n\n\n\n
\n
\n
\n
\n"},{"wysiwyg":"
Taylorgrams were obtained for a range of Gelucire® 44/14 concentrations (1 to 70 g/L) and the molecular diffusion coefficient (D) and the hydrodynamic radius (Rh) were calculated.
\nThe results are not impacted by temperature as the radius obtained at 25 and 37°C are identical using TDA, which is not the case with DLS. The difference in the radius obtained by both techniques is explained by the presence of small quantities of large aggregates which give higher radius values using DLS, but not with TDA.
\nGelucire® 44/14 microdroplet radius increases from 1 to 5.5 nm with increasing concentration from 1 to 70 g/L using TDA.
\n\n"},{"wysiwyg":"Since Labrasol® ALF forms coacervates below 20 g/L at 25°C and below 40 g/L at 37°C, TDA is coupled with fluorescent detection to avoid the noise associated with the coacervates.
\nLabrasol® AFL microdroplet radius decreases from 90 to 6 nm with increasing concentration from 1 to 70 g/L.
\n\n"},{"wysiwyg":"
The lipolysis test was applied to solutions of Gelucire® 44/14 and Labrasol® ALF. Samples were taken over time and analysed using TDA coupled with fluorescence detection.
\nDuring Gelucire® 44/14 lipolysis there is a plateau for about 30-40 min, then the hydrodynamic radius of Gelucire® 44/14 micelles increases with a sigmoidal shape from about 5 nm to about 25 nm.
\nDuring Labrasol® ALF lipolysis, the size of the micelles decreases from about 12 nm to reach a plateau at about 3.5 nm after 20 minutes.
\nAlthough both excipients behave very differently upon lipolysis, micelles could still be detected up to 120 minutes of digestion.
\n"},{"wysiwyg":"The aim of this study is to quantify the free fraction of peptides in ion pair SEDDS formulations using TDA and leuprorelin and desmopressin as model peptides. The influence of the ionic strength on peptide release is also evaluated.
\nIn the case of leuprorelin the radius decreases exponentially from about 11.9 nm to 2.8 nm at 150 mM ionic strength, suggesting the release of a large amount of peptide.
\nIn the case of desmopressin, the radius decreases from about 4.1 nm to 0.7 nm at 150 mM ionic strength, showing a total release of the peptide.
\nThe proportion of free peptide as a function of ionic strength could be deduced.
\nDesmopressin appears to be totally released from the SEDDS at physiological saline conditions (150 mM), whereas leuprorelin is released at 80%.
\n"},{"wysiwyg":"\n"}],"content_not_translated":false,"equivalent_fr":false,"equivalent_en":false},"_links":{"self":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/16268"}],"collection":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages"}],"about":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/types/page"}],"author":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/users/9"}],"replies":[{"embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/comments?post=16268"}],"version-history":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/pages/16268/revisions"}],"wp:attachment":[{"href":"https://www.gattefosse.com/wp-json/wp/v2/media?parent=16268"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/categories?post=16268"},{"taxonomy":"post_tag","embeddable":true,"href":"https://www.gattefosse.com/wp-json/wp/v2/tags?post=16268"}],"curies":[{"name":"wp","href":"https://api.w.org/{rel}","templated":true}]}},"excipients-for-suppositories-and-pessaries":{"id":3900,"date":"2017-05-04T07:51:21","date_gmt":"2017-05-04T07:51:21","guid":{"rendered":"https://www.gattefosse.com:443/?page_id=3900"},"modified":"2021-04-07T10:36:14","modified_gmt":"2021-04-07T08:36:14","slug":"excipients-for-suppositories-and-pessaries","status":"publish","type":"page","link":"https://www.gattefosse.com/fr/pharmaceuticals-content/excipients-for-suppositories-and-pessaries/","title":{"rendered":"Excipients for Suppositories and Pessaries"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"Excipients for suppositories and pessaries | Gattefossé","_yoast_wpseo_metadesc":"Discover our wide range of hard fat bases for suppositories and pessaries and select the most appropriate base for your active ingredient."},"categories":[49],"tags":[],"acf":{"component":"PageGenericContentPharma","title":"Excipients for Suppositories and Pessaries","content":"
Suppocire® and Ovucire™ are our well-established brands of semi-synthetic hard fat bases comprising fatty acid esters. Their physicochemical properties have been optimized to provide excellent drug delivery for both solid and liquid active pharmaceutical ingredients (APIs), across the range of water solubility.
\n
\n
We offer a wide range of bases for suppositories and pessaries. Here you will find a selection of the most versatile grades. Our bases and formulation expertise enable you to:
\nThese multipurpose vehicles span a range of melting points and hydroxyl values and are suitable for a wide spectrum of APIs. They are ideal for straightforward formulations using manual, semi-automated, or fully automated equipment.
\nSuppocire® Grade | \nSuppocire® Main Characteristics | \n
Suppocire® AM | \nLow melting point | \n
Suppocire® NAI 25 A | \nLow melting point; long-chain glycerides enable production of hard suppository units | \n
Some APIs are more difficult to formulate due to properties such as hydrophilicity, sensitivity to oxidation, or high drug load. They require special bases like the following:
\nDrug Characteristics | \nSuppocire® Grade | \n
Liposoluble | \nSuppocire® CM | \n
Hydrophilic | \nSuppocire® NAS 50 | \n
Glycerin | \nSuppocire® AGP | \n
Sensitive to oxidation | \nSuppocire® NA 15 | \n
Ovucire™ Grade | \nOvucire™ Main Characteristics | \n
Ovucire™ 3460 | \nGood mechanical resistance and enhanced spreadability within the vaginal cavity | \n
Ovucire™ WL 3264 | \nWith additive to enhance API dispersion and wettability | \n
\n
Contact Gattefossé to obtain reference formulations with APIs such as acetaminophen, clotrimazole, diclofenac sodium, econazole nitrate, hydrocortisone acetate, ketoprofen, lidocaine hydrochloride, mesalamine, metronidazole, miconazole nitrate, nystatin, papaverine, phloroglucinol, piroxicam, probiotics, procaine, progesterone, and ruscogenin in association with trimebutine.
A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms.
\n","names_kv":[{"keys":"USP NF Name","value":"Propylene Glycol Mono and Dicaprylate NF
\n[May also be labeled as Propylene Glycol Monocaprylate (type I) NF until December 1, 2026]
/
\n"},{"keys":"UNII Code (FDA)","value":"RT9P9S09QI
\n"},{"keys":"Preferred Substance Name (FDA)","value":"PROPYLENE GLYCOL CAPRYLATE
\n"},{"keys":"Handbook of Pharmaceutical Excipients","value":"Propylene glycol monocaprylate
\n"},{"keys":"Chemical description","value":"Consists of propylene glycol esters of caprylic acid (C8), composed of mono- and diesters.
\n"}],"key_characteristics_kv":[{"keys":"Product form","value":"Oily liquid
\n"},{"keys":"Viscosity (mPa.s)","value":"20 (20°C)
\n"},{"keys":"HLB","value":"6
\n"}],"main_functionalities":"Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulation. Safety of use is inferred by precedence of use in approved pharmaceutical products.
\n","main_formulation_technologies":"Self-emulsifying lipid formulation for oral applications. Topical emulgel, microemulsion.
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","date":"2019.03.11","content":"High shear coating is a process in which powdered lipid excipient is mixed with the API in a high shear coater, without external heating. During mixing, frictions are generated. They are responsible for the production of heat and consequently of the partial melting of the lipid excipient. The partially molten lipid excipient coats the drug particles. Upon cooling the lipid coating solidifies and efficiently covers the drug particle, masking its taste.
\nRange of excipients for high shear coating
\nAt Gattefossé, we base our industrial operations on two complementary know-how: lipid chemistry and plant extraction.
\n\n
Gattefossé industrial activities are based on two fields of expertise: lipid chemistry and plant extraction.
\n
Lipid chemistry (Lipochemical) engineering underpins the manufacturing of functional ingredients for the pharmaceutical and personal care industries. Production processes are based on esterification and interesterification of fatty substances of plant origin with hydrophilic molecules. These chemical reactions may be followed by downstream processes such as distillation or winterization to obtain finished product. No flammable solvents are used in these reactions.
\n\n
Extraction processes are specifically designed for the raw materials we use – plants, part of plants and flowers – to obtain the highest quality actives and extracts.
\n
\n
Gattefossé has implemented an unique enduring industrial model, for over 60 years, which combines internal and outsourced production to trusted partners.
\n
\n
At Gattefossé, we base our industrial operations on two complementary know-how: lipid chemistry and plant extraction.
\n\n
Gattefossé industrial activities are based on two fields of expertise: lipid chemistry and plant extraction.
\n
Lipid chemistry (Lipochemical) engineering underpins the manufacturing of functional ingredients for the pharmaceutical and personal care industries. Production processes are based on esterification and interesterification of fatty substances of plant origin with hydrophilic molecules. These chemical reactions may be followed by downstream processes such as distillation or winterization to obtain finished product. No flammable solvents are used in these reactions.
\n\n
Extraction processes are specifically designed for the raw materials we use – plants, part of plants and flowers – to obtain the highest quality actives and extracts.
\n
\n
Gattefossé has implemented an unique enduring industrial model, for over 60 years, which combines internal and outsourced production to trusted partners.
\n
\n