Capryol™ PGMC

A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms.

Names and synonyms

USP NF Name

Propylene glycol monocaprylate (type I) NF

EP Name

/

UNII Code (FDA)

RT9P9S09QI

Preferred Substance Name (FDA)

PROPYLENE GLYCOL CAPRYLATE

Handbook of Pharmaceutical Excipients

Pending

Chemical description

Consists of propylene glycol esters of caprylic acid (C8), composed of mono- and diesters.

Key characteristics

Product form

Oily liquid

Viscosity (mPa.s)

20 (20°C)

HLB

6

Main functionalities

Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulation. Safety of use is inferred by precedence of use in approved pharmaceutical products.

Main formulation technologies