In order to assist in the selection of an appropriate vehicle for in vivo non-clinical safety assessment studies, this document has been specifically designed for use by toxicologists, and scientists working at the early stages of formulation development.
A candidate vehicle or formula must meet defined performance criteria for use in pre-clinical studies including:
Lipid based drug delivery systems meet these needs, but in order to be used successfully in preclinical assessment one must fully understand their physico-chemical properties in relation to the application/objective at hand, and employ working methods appropriate to each case.
This Guideline document provides our key recommendations for best practice and contains easy-to-use reference data tables. We hope that this information will simplify the task and enable researchers to make choices appropriate to their projects; to save time in data searching; and to maximize speed and efficiency in the study design process.
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