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The physicochemical properties of lipids mean they can be used in numerous formulation and processing techniques enabling the development of innovative and improved drug delivery systems. To find out more see our ‘Formulation Guideline’ and ‘Processing Sheet’ documents.

Depending on the choice of excipient(s) and formulation techniques, it is possible to obtain a variety of drug delivery systems including immediate and modified release. Formulation techniques include physical mixtures, liquid/solid solutions, solid dispersions, and self-emulsifying or self-micro emulsifying drug delivery systems (SEDDS and SMEDDS).

These systems may then be incorporated into capsules directly, or transformed into granules, pellets, and powders for dry filled capsules as well as tablet preparations. The latter are possible by innovative adaptations of conventional equipment with relative ease and process simplicity, using methods like melt granulation, adsorption on solid support, spray cooling, melt-extrusion / spheronization. These innovative approaches offer considerable process advantages over conventional methods because they are:

•    Solvent free (environmental protection against inorganic solvents)
•    Water free (anhydrous formulations suitable for water sensitive active drugs)
•    One step process (no drying, shorter processing time)
•    Simple to manufacture (reduced number of excipients and related costs)

Explore this section of our website for Formulation Guidelines and practical advice.

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