Compritol® 888 ATO is a fine powder of well-defined particle size with excellent tabletting properties. In direct compression it offers multiple functions, depending on the method and level of excipient use.
- In direct compression, Compritol® 888 ATO is a universal tablet lubricant when used at concentrations of under ~3%.
- At higher use levels (5 to 30%) direct compression with Compritol® 888 ATO can produce a water insoluble matrix for sustained drug release (SR).
Compritol® 888 ATO is successfully utilized as a lubricant or a SR agent in a number of internationally marketed drugs. See our Formulation Guideline for the use of Compritol® 888 ATO in direct compression to obtain sustained release tablets. The document centre also contains many references for the production of tablets.