Lipid excipients provide a formulation approach for poorly water soluble active pharmaceutical ingredients (APIs) to improve oral bioavailability.
The Biopharmaceutical Classification System (BCS) has historically provided a useful starting point in defining drug development approaches for APIs classified as:
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Class I: high aqueous solubility,
high permeability
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Classe II :low aqueous solubility,
high permeability
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Classe III : high aqueous solubility,
low permeability
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Class IV: low aqueous solubility,
low permeability
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Lipid excipients provide a formulation approach for Class II and can potentially be used with Class III and IV APIs, due to their functional properties which include:
- Improvement of the solubility / wettability of the API in the dosage form.
- Improvement of the solubility / wettability of the API in the dosage form.
- Maintenance of the API in a solubilized state, protecting against drug precipitation.
- Working in synergy with in-vivo processes to improve drug absorption.
Our excipients can be used to develop self-emulsifying lipid formulations (SELF), which include SEDDS and SMEDDS (self-(micro) emulsifying drug delivery systems).They can be used in hard and soft gelatin capsules and liquid formulations can be adsorbed onto inert compressible powders for tableting by direct compression or other techniques.
We have developed a range of documents to help you and in the Formulation Techniques section of this website you can find details about liquid and Solid-SELF and the ‘Formulation Guidelines for developing lipid based formulations for oral bioavailability enhancement’ as well as information on the use of lipid excipients in preclinical studies.
- Maintenance of the API in a solubilized state, protecting against drug precipitation.
- Working in synergy with in-vivo processes to improve drug absorption.
Our excipients can be used to develop self-emulsifying lipid formulations (SELF), which
include SEDDS and SMEDDS (self-(micro) emulsifying drug delivery systems).They can
be used in hard and soft gelatin capsules and liquid formulations can be adsorbed onto
inert compressible powders for tableting by direct compression or other techniques.
We have developed a range of documents to help you and in the Formulation
Techniques section of this website you can find details about liquid and Solid-SELF and
the ‘Formulation Guidelines for developing lipid based formulations for oral
bioavailability enhancement’ as well as information on the use of lipid excipients in
preclinical studies.
